Results 61 to 70 of about 18,866 (201)
Effects of Rh-endostar in Combination with Radiotherapy on Rats with Lung Cancer [PDF]
, 2010 Background and objective Radiation sensitivity is closely related to tissue oxygen, and rh-endostatin can induce the high level of oxygen content in tumor by "normalizing" tumor angiogenesis which is associated with radiotherapy sensitivity.
Changhu LI +5 more
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Policy Studies Journal, EarlyView.Abstract Though spillovers have been initially described in the Multiple Streams Framework (MSF), we know little about how to conceptualize and measure them. To investigate spillovers, we draw on the case of fur farming bans during the COVID‐19 pandemic. Whereas fur farming has long been criticized for its animal welfare problems, with the onset of the
Anne‐Marie Parth +3 more
wiley +1 more source
Zhongguo shiyan zhenduanxue在腰椎间盘突出症（lumbar disc herniation,LDH）领域，实验动物模型的建立至关重要。本文综合评估了不同类型的LDH动物模型。腰椎间盘退行性病变模型模拟了LDH的早期发病机制，LDH模型则可分为压迫性模型和非压迫性模型。总体而言，不同实验动物模型在模拟LDH病理过程中各具特点，为疾病机制研究和药物开发提供了重要的参考借鉴。未来研究可进一步优化不同模型，以更好地模拟临床情况，促进相关研究进一步发展。
曹卓妍 +4 more
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Zhongguo shiyan zhenduanxue, 2017 目的观察胆管内放置曲安奈德可降解胆道支架后胆管ɑ平滑肌肌动蛋白（ɑ-SMA）及转化因子β1（TGF-β1）在兔胆管损伤动物模型修复期间的表达情况,研究应用曲安奈德药物覆膜的可降解胆道支架在兔胆管损伤动物模型中抑制胆管炎性狭窄的机制。方法通过兔胆管损伤动物模型将应用曲安奈德药物涂层的可降解胆道支架和无曲安奈德涂层可降解胆道支架分别放置兔肝外胆管60只,平均随机分成6组,选取放置胆道支架后第30天、60天、90天分别处死1组兔动物模型,取材兔损伤修复模型的胆管并且应用免疫组织化学的方法分别检测ɑ ...
宋楠 +5 more
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The impact and the functional mechanism of autologous platelet-rich plasma on free flap graft survival: A preliminary study in rabbits [PDF]
, 2016 摘要 研究目的：探讨局部应用PRP对游离皮瓣存活的影响，深入了解自身来源的富血小板血浆（PRP）在皮瓣转移过程中的作用，并初步探讨PRP影响游离皮瓣生长的作用机制，为PRP的实验研究和临床应用提供理论依据。 研究方法：将30只新西兰大白兔编号，用随机数表法随机分为实验组和对照组，每组15只新西兰大白兔。取兔子自身动脉血制备PRP，检测PRP中血小板和生长因子浓度，并计算其浓缩倍数。实验组处理：游离皮瓣基底部涂抹1.0ml的PRP，然后将游离皮瓣原位缝合；对照组处理：游离皮瓣基底部涂抹1.0ml的生理盐水，
王彪
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Veterinary Dermatology, EarlyView.Background: Canine atopic dermatitis (cAD) is a common, chronic skin condition characterised by epidermal barrier dysfunction, immune dysregulation and cutaneous dysbiosis. While “emollient plus” formulations are widely used in human atopic dermatitis, their role in cAD remains underexplored. Hypothesis/Objectives: To evaluate the clinical efficacy and
Beatriz Fernandes +8 more
wiley +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 1992 用阿霉素(ADR)诱导雄性大鼠肾病模型,选用氧自由基清除剂超氧化物歧化酶(SOD),以及非氧自由基清除剂环孢素A(CSA)对动物模型进行干扰,结果显示其模型组动物在实验的第14天出现典型肾病综合征症候;SOD组动物的尿,血生化指标及病理损害得到明显的改善,且血清和肾皮质的丙二醛(MDA)含量也明显低于ADR模型组的指标;CSA组则无上述作用,提示ADR能致使动物肾病模型是与氧自由基、脂质过氧化损伤有关。
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Zhongguo shiyan zhenduanxue, 2008 目的探索经大鼠肝脏门静脉实施骨髓间充质干细胞（MSC）输入的入路,并建立合理的经门脉介入给药动物模型。方法20只正常SD大鼠和20只肝硬化大鼠为实验动物模型。选择盲肠静脉、脾静脉,脾脏和肠系膜下静脉的适合穿刺点,分别实施门静脉DSA造影。确定合适的门静脉DSA造影入路,建立门脉介入给药动物模型。结果通过各入路的DSA比较表明,盲肠静脉作为入路,DSA下可以清晰显示门静脉,穿刺成功率100%,大鼠门脉给药动物模型存活均72 h。结论经盲肠静脉入路进行肝脏给药安全、可行 ...
吕文天 +9 more
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Mechanistic Analysis of Immunomodulation by Human Induced Pluripotent Stem Cells Derived Mesenchymal Stem Cells in Mice [PDF]
, 2015 背景：间充质干细胞是具有自我更新能力和分化能力的组织细胞前体细胞，能够分化为一系列的间质细胞，包括成骨细胞、成软骨细胞、脂肪细胞、肌细胞和内皮细胞等。细胞治疗是再生医学发展的一个重要分支。越来越多的研究发现，间充质干细胞能够修复组织损伤，达到一定治疗效果。因此，间充质干细胞被视为天然组织工程材料的重要种子细胞，具有广阔的应用前景。此外，间充质干细胞具有负性免疫调节能力。在体外共培养条件下，间充质干细胞能够抑制免疫细胞功能，包括抑制T细胞反应，抑制树突状细胞的成熟和抗原提成，抑制B细胞激活和增殖 ...
李成林
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Veterinary Dermatology, EarlyView.ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon +5 more
wiley +1 more source