Results 11 to 20 of about 3,641 (152)
Journal of Diabetes, Volume 15, Issue 11, Page 987-993, November 2023., 2023 Highlights We used data from the genome‐wide association studies database and two‐sample mendelian randomization method, we found that genetic evidence supporting that knee osteoarthritis is a potential risk factor for type 2 diabetes. Abstract Background Physical inactivity is an independent risk factor for type 2 diabetes (T2D).
Xing Xing +3 more
wiley +1 more source
Evaluation and redesign of the primers for detecting nitrogen cycling genes in environments
Methods in Ecology and Evolution, Volume 13, Issue 9, Page 1976-1989, September 2022., 2022 Abstract A better understanding of how nitrogen (N) cycling genes are involved in ecological processes is one of the crucial areas of microbial ecology. Currently, most molecular biological techniques investigating N cycling genes in the environment heavily rely on the accuracy of the polymerase chain reaction (PCR) primers; however, their specificity ...
Zhujun Wang +12 more
wiley +1 more source
Journal of Diabetes, Volume 13, Issue 2, Page 143-153, February 2021., 2021 Highlights A machine learning model can significantly predict imminent development of islet autoimmunity based on environmental, genetic, and metabolic features. The machine learning algorithm feature selection identified type 1 diabetes‐associated single nucleotide polymorphisms from The Environmental Determinants of the Diabetes in the Young (TEDDY ...
Bobbie‐Jo M. Webb‐Robertson +10 more
wiley +1 more source
Journal of Diabetes, Volume 11, Issue 11, Page 857-868, November 2019., 2019 Highlights Ten single nucleotide polymorphisms were found to be associated with diabetes risk. There were significant associations of diabetes genetic risk scores and weighted diabetes genetic risk scores with fasting plasma glucose and diabetes. Abstract Background Genome‐wide association studies have identified loci that significantly increase ...
Chao Song +11 more
wiley +1 more source
Integrative Conservation, Volume 4, Issue 3, Page 277-286, September 2025.This study provides an innovation to address the challenge in accessibility to samples and genetic markers in Snow leopard conservation genetic studies. We performed next‐generation sequencing (NGS) on 19 fecal samples obtained from the eastern Qinghai‐Tibet Plateau, and successfully assembled 17 complete mitogenome sequences (~16,720 bp) and ...
Chen Cheng +7 more
wiley +1 more source
Molecular cloning, expression of heat shock protein 60 (HSP60) gene in Marsupenaeus japonicus and the association of its polymorphisms with thermal tolerance [PDF]
, 2015 日本囊对虾(Marsupenaeusjaponicus)是我国重要经济养殖虾类，但其在南方地区存在着高温度夏死亡率较高的养殖难题。因此，急需了解日本囊对虾的耐热性状及耐温的分子机制，为此，我们开展了日本囊对虾MjHSP60基因的克隆、表达分析及其多态性与耐热性状相关性的研究，获得了如下主要结果： 1.MjHSP60基因克隆 在日本囊对虾MjHSP60cDNA序列基础上克隆到了该基因DNA全序列。日本囊对虾MjHSP60基因全长4055bp，结构与拟穴青蟹一致，均由8个外显子及7个内含子构成 ...
李丽君
core
Genetic diversity of tartary buckwheat based on the sequence analysis of PAL [PDF]
, 2018 Tartary buckwheat is widely cultivated in different areas of China and gradually evolved into genetic diversity. In order to study and utilize the tartary buckwheat, the PAL gene differences of the tartary buckwheat were analyzed on 67 samples,which were
Gao, J. +4 more
core +1 more source
Screening of SNP Loci of Growth-related Candidate Gene and Genetic Diversity of Five Populations Based On Microsatellite Markers in Fujian Oyster, Crassostrea angulata [PDF]
, 2015 福建牡蛎(Crassostreaangulata，C.angulata)又名葡萄牙牡蛎，具有重要的经济价值和生态价值，但由于长期未经选育以及人工育苗的应用，导致牡蛎养殖出现经济性状衰退及死亡率逐年增高等现象，亟需加强种质资源保护，开展遗传改良研究。本研究利用单核苷酸多态性分子标记（singlenucleotidepolymorphism，SNP）对福建牡蛎生长相关的5个候选基因，即胰岛素相关多肽（insulinrelatedpeptides，IRPs）、ɑ-淀粉酶（ɑ-Amylase，ɑ-AMY ...
楚瑞敏
core
Zhongguo shiyan zhenduanxue, 2012 目的采用高分辨熔解曲线（high-resolution melting,HRM）方法检测7个2型糖尿病（T2DM）患者相关易感单核苷酸多态性,并分析该多态性与2型糖尿病的相关性。方法选取202名T2DM患者和200名健康志愿者,提取外周血DNA,采用HRM技术分析其多态性,并用测序法证实。结果成功地检测T2DM患者相关易感单核苷酸多态性。HRM技术检测能准确区分各种基因型,其结果与测序法一致;研究还显示rs10811661和rs10923931位点在本研究人群中与T2DM无相关 ...
左玲, 左磊
doaj
The effect of PNPLA3 ploymorphism in the intervention of non-alcoholic fatty liver disease [PDF]
, 2015 研究目的 运动是治疗非酒精性脂肪性肝疾病的一个重要方法，而脂肪滋养蛋白基因（PNPLA3）是非酒精性脂肪性肝疾病的一个重要的基因遗传因子。本研究的目的是为了探讨脂肪滋养蛋白基因的多态性表达是否影响到运动干预非酒精性脂肪性肝疾病的过程。 研究方法 本研究共招募40-65岁中心性肥胖受试者1059人，进行常规体检，并运用彩超检测脂肪肝。并随机抽取476名肥胖受试者进行1H-MRS对其肝内甘油三酯进行定量测定。在这476名肥胖受试者中，随机抽取220人分为三组，强化运动组（先进行6个月的强化运动期 ...
黄竹锋
core