Exploratory analysis of gut microbiota differences in childhood asthma with different severity [PDF]
, 2023 Objective·To explore the characteristics and differences of gut microbiota in children with different severity of bronchial asthma, and build a prediction model of gut microbiota in severe asthma.Methods·In this study, children aged 5 to 14 diagnosed ...
HAN Xiao +3 more
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Oral health status of asthmatic preschoolers in Hong Kong [PDF]
, 2010 published_or_final_versio
Chan, BKL +7 more
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New insights in small airway dysfunction of childhood asthma [PDF]
, 2023 Small airway dysfunction (SAD) widely exists in different stages of childhood asthma, which is based on airway inflammation, airway remodeling and airway hyperresponsiveness. Among them, airway inflammation is the main pathological feature of SAD. It has
DONG Xiaoyan, ZHU Siyu
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Prevalence of allergic rhinitis and its associated morbidity in adults with asthma: A multicentre study [PDF]
, 2010 Objectives To assess the prevalence of allergic rhinitis in adult patients with asthma in Hong Kong, and to compare the morbidity endured by asthma patients with and without allergic rhinitis. Design Cross-sectional study.
Chu, CM +5 more
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Effects of PM2.5 on Naive T Cell Differentiation in Asthma [PDF]
, 2017 支气管哮喘(asthma)，简称哮喘，是一种以气道高反应性和可逆性气道阻塞为特点的慢性炎症性疾病。虽然对哮喘发病机制和治疗的研究取得了很大进展，但全世界哮喘发病率和死亡率仍呈现上升趋势。哮喘的发病危险因素包括遗传因素（内因）和环境因素（外因）两个方面。环境因素作为诱发哮喘和哮喘急性发作的重要危险因素，主要包括过敏原、气候变化和空气污染等。PM2.5致病的主要原因是由于细颗粒物粒径小，比表面积大，活性强，容易吸附空气中的各类有毒成分。我们前期研究发现PM2.5 ...
葛丹丹
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Review of CD4+ T cell subsets in asthma phenotypes: molecular mechanisms and biologic treatment options [PDF]
, 2023 Asthma is a chronic inflammatory airway disease, mainly driven by different CD4+ T cell subsets [helper T cell (Th cell)]. CD4+ T cell subsets are a type of important immune cells, capable of secreting various cytokines, and regulating the immune ...
WANG Chuanping, ZHAO Yanhong
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Airborne fine particle decreases the cell viability and induces inflammation in human bronchial epithelial cells [PDF]
, 2017 目的:研究大气细颗粒物(fine particulate; matter,PM_(2.5))对人支气管上皮细胞活性的影响及其炎性作用。方法:用PM_(2.5)采样器采集上海地区大气PM_(2.5)样本,扫; 描电镜观察PM_(2.5)形态特征。将人支气管上皮细胞BEAS-2B暴露于不同浓度(0,50,100,200,400,800; mug/mL)的PM_(2.5) 12,24,48 h,细胞活力检测试剂盒(cell counting kit-8,; CCK-8)法检测PM_(2.5 ...
庄国顺 +4 more
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Diagnosis and treatment practice of chest tightness variant asthma in China [PDF]
, 2023 Chest tightness variant asthma (CTVA) is an atypical form of asthma, characterized by chest tightness as the primary symptom, without the typical asthma symptoms， such as recurrent wheezing and shortness of breath.
HUA Wen, SHEN Huahao
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支气管哮喘患者诱导痰炎性细胞中Tim-3 mRNA的表达及作用机制研究
Zhongguo shiyan zhenduanxue, 2015 目的探讨支气管哮喘患者诱导痰炎性细胞中Tim-3mRNA的表达及作用机制,并分析其与上清液中IL-4、IFN-γ和肺功能指标的相关性。方法将2012年5月-2013年8月我院收治的支气管哮喘患者分为哮喘缓解组和哮喘发作组,并于同期随机选取120例健康体检者为对照组,通过逆转录-聚合酶链反应技术（RT-PCR）检测三组的诱导痰炎性细胞中Tim-3mRNA的水平,同时采用酶联免疫吸附法（ELISA）检测上清液中IL-4、IFN-γ,分析其与Tim-3mRNA的相关性。结果哮喘发作组、哮喘缓解组FEV1 ...
汤菲, 王缚鲲, 安黎云, 贾克然
doaj
, 2001 研究一氧化氮 (NO)在哮喘大鼠肺组织中的作用。采用组化法观察一氧化氮合酶 (NOS)在大鼠哮喘模型肺组织中的分布 ,应用免疫组化法观察大鼠哮喘模型气道mIL 2R+ 细胞变化。结果显示 ,哮喘大鼠肺NADPH染色呈强阳性 ,并波及肺泡膈。肺组织中NOS含量明显高于对照组 [哮喘组 (37 44± 0 77)pmol/mg,对照组 (8 73± 0 79)pmol/mg],气道炎性细胞增多 ,特别是mIL 2R+ 细胞 [哮喘组mIL 2R+ 细胞为 (2 3 8± 7 9)个 ,对照组为 0个 ...
肖彭年, 莫榴琴, 高丰光
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