线粒体质量控制在外源化学物引起坏死性凋亡中的作用 [PDF]
, 2018 坏死性凋亡是一种可调控的、半胱氨酸天冬氨酸蛋白酶(Cysteine aspartic acid specific protease,Caspase)非依赖的程序性细胞死亡,相较于细胞凋亡,其主要特点是没有核固缩和气球样变,而出现的是线粒体肿胀和三磷酸腺苷(Adenosine triphosphate,ATP)耗竭、胞质肿胀和空泡形成,其最终引起质膜破裂和通透性改变,释放损伤相关分子,如白细胞介素1α、高国家自然科学基金(81573181,81472997);;福建省自然科学基金 ...
张仕利, 林忠宁, 林育纯
core
The influences of necrostatin-1 on endoplasmic reticulum stress after spinal cord injury [PDF]
, 2017 目的：探讨脊髓损伤（SpinalCordInjury，SCI）后运用坏死性凋亡抑制剂Nce-1（Necrostatin-1）是否对于脊髓损伤后的内质网应激(ERS)有减轻作用，进一步补充Nec-1对于脊髓损伤的保护作用机制。为脊髓损伤后的治疗提供新的思路及治疗方向。 方法：采用60只雄性，SPF级SD大鼠，体重0.25到0.30kg之间。将这些大鼠随机分为4组：假手术组（Sham组，I组）、假手术+Necrostatin-1治疗组（sham+Nec-1组，II组）、SCI+Necrostatin ...
王双
core
Transcriptome Analysis of Effect of Cordyceps militaris Aqueous Extract in Human Gastric Cancer Cell BGC-823 on Different RCD Pathways [PDF]
Objective: The main regulated cell death (RCD) signaling pathway of Cordyceps militaris (XG) water extract that affects the growth activity of the human gastric cancer cell line BGC-823 was analyzed and predicted using transcriptome sequencing technology.
Fangxu XU +5 more
core +1 more source
Pregnane X receptor involves in the effect of aflatoxin B1 on necroptosis in human normal L02 liver cells [PDF]
, 2014 目的初步探讨孕烷X受体(PXr)对黄曲霉毒素b1(Afb1)诱导肝细胞dnA损伤和坏死性凋亡的影响。方法采用已构建的PXr高表达l02-PXr和空白载体对照l02-P b细胞;实时荧光定量PCr(Q rT-PCr)检测细胞nr1I2和CyP3A4 M rnA水平改变;蛋白免疫印迹(WESTErn blOTTIng)检测细胞内PXr和坏死性凋亡下游效应自噬分子lC3-Ⅰ和lC3-Ⅱ蛋白相对表达含量;双核微核试验(CbMn)检测细胞遗传损伤情况;采用噻唑蓝(MTT)法测定Afb1对细胞活性抑制影响 ...
何承勇 +6 more
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Research progress in mitochondrial dynamics-related proteins and ischemic stroke [PDF]
Ischemic stroke is a common acute cerebrovascular disease in clinical practice， which poses a severe threat to human health. In recent years， with deepening understanding of ischemic stroke， significant progress has been made in the diagnosis and ...
Li Tingting, Wang Qinpeng, Liu Xiaoqing, Cai Ke, Wei Yangyang, Liang Cheng
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, 2020 近年来，登革病毒在全球热带与亚热带地区暴发流行，感染例数居高不下，严重危害了公共卫生安全。在登革病毒感染后，宿主细胞迅速激活多条信号通路，以应对和抵御病毒的入侵；另一方面，登革病毒演化出多种逃逸、拮抗甚至利用细胞应答的策略。本综述简要综述了登革病毒的分子生物学，以及细胞抗病毒的应答（包括固有免疫应答、适应性免疫应答、细胞死亡、自噬、未折叠蛋白反应、应激颗粒形成 ...
张萍
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Research Progress in Ferroptosis during Postmortem Aging of Muscle and Its Relationship with the Quality of Fresh Meat [PDF]
Water-holding capacity, texture and color are important indicators of fresh meat quality. In China, drip loss and textural deterioration of fresh meat are critical problems in the meat industry, causing greater quality loss than that in developed ...
HAO Danni, TU Xiaohang, GUO Shiyu, ZHU Yongzhi, WANG Daoying, XU Weimin, LI Pengpeng
core +1 more source
Zhongguo shiyan zhenduanxue, 2023 铜(Cu)是人体必须的微量元素,在线粒体呼吸、抗氧化防御和生物复合物合成等多种细胞生命过程中发挥重要辅助功能[1]。然而,生理条件下细胞内Cu浓度较低,Cu浓度小幅度升高可能引起细胞毒性,甚至导致细胞死亡[2]。细胞内铜的摄取、分布和消除等过程受到机体严格调控。基因突变导致Cu过量累积与多种致命性疾病的发生密切相关。因此,充分理解细胞内Cu积累和代谢机制对于疾病的治疗至关重要[3]。铜死亡是一种由Cu2+过度蓄积引发的细胞调控性死亡方式,不同于细胞凋亡、铁死亡和坏死[4]。铜死亡发生的过程如下 ...
单关月 +4 more
doaj
Lipid signatures of acute kidney injury to chronic kidney disease transition [PDF]
Objective To explore lipid signatures of renal tissue in acute kidney injury （AKI） and AKI-to-CKD transition by untargeted lipidomics. Methods Ischemia-reperfusion injury （IRI） mice were subjected to bilateral renal pedicle clamping for 30 min.
Jie-yi Luo +5 more
core +1 more source
Role of tubular cell-derived exosomes in renal ischemia reperfusion injury [PDF]
Renal ischemia reperfusion injury refers to a pathophysiological phenomenon that aggravates the degree of renal injury due to the restoration of blood supply after transient ischemia of renal tissue.
Ai-sha Zhang +7 more
core +1 more source