Results 51 to 60 of about 2,335 (98)

[Cisplatin promotes TNF-α autocrine to trigger RIP1/RIP3/MLKL-dependent necroptosis of human head and neck squamous cell carcinoma cells]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Wang H, Tao D, Ma J, Zhang D, Shen Z, Deng C, Zhou J.   +6 more
europepmc   +1 more source

miRNA-124调控ERK/p38 MAPK-NLRP3通路对脓毒症心肌损伤的作用机制

Zhongguo shiyan zhenduanxue
目的探讨miRNA-124通过调控ERK/p38 MAPK-NLRP3炎性小体通路对脓毒症心肌损伤的作用。方法选取50只C57BL/6小鼠，随机分为正常对照组、模型组、miRNA-124敲除模型组、ERK抑制剂组和p38MAPK抑制剂组5组，每组10只。采用H&E染色评估心脏损伤，TUNEL法检测凋亡，ELISA测定炎症因子水平，Western blot分析相关蛋白表达。结果模型组出现明显的心肌细胞浸润、水肿和坏死，伴随凋亡增加及TNF-α、IL-1β、IL-6等炎症因子升高，miRNA ...
吴言悟, 许安娜, 王燊妮, 林晓鸿, 李秀珍, 纪腾飞   +5 more
doaj  

[Research progress on the quercetin target role and signaling pathway in anti-liver fibrosis]. [PDF]

Zhonghua Gan Zang Bing Za Zhi
Zhao RQ, Liu HY, Yan JM, Hao Y, Ding YX, Zhang F, Zhou RM, Zhao R, Bai F, Bai WF.   +9 more
europepmc   +1 more source

miR-143-3p对人子宫内膜基质细胞增殖活性和炎性因子表达的影响

Zhongguo shiyan zhenduanxue
目的 评估人脐带间充质干细胞外泌体(hUCMSC-Exos)对米非司酮诱导的子宫内膜基质细胞(hESCs)损伤的逆转作用，并筛选hUCMSC-Exos中发挥作用的microRNA。方法 以米非司酮(mifepristone)、人脐带间充质干细胞来源外泌体(hHUCMSC-Exos)和miRNA单独或联合作用于子宫内膜基质细胞(hESCs),分为mifepristone组、mifepristone+hHUCMSC-Exos组、mifepristone+miRNA组，加入等量生理盐水的hESCs为对照组 ...
于歆悦, 米旭光, 林秀英, 付建华, 刘磊, 李首庆, 高心月, 方艳秋   +7 more
doaj  

[Effects of miR-100-5p on proliferation and apoptosis of acute myeloid leukemia cells and the underlying molecular mechanism]. [PDF]

Zhongguo Dang Dai Er Ke Za Zhi
Fan XR, Yang Y, Sun Y, DU CM.
europepmc   +1 more source

[<i>Huayu Tongbian</i> Decoction promotes efferocytosis of interstitial Cajal cells in rats with slow transit constipation by inhibiting the PI3K/Akt signaling pathway]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Qiu J, Chen M, Man R, Chen X, Qiu D, Chang Q, Ma H.   +6 more
europepmc   +1 more source

[Effect of interleukin-33 on glucocorticoid-induced osteonecrosis of the femoral head in mice]. [PDF]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Li H, Shen M, Liu H, Zhou Y, Gao F, Cheng L, Wang B, Ma J.   +7 more
europepmc   +1 more source

[Research progress on lactylation modification in pathogenesis of osteoarthritis]. [PDF]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Wu Y, Sun K, Ding Y, Li M, Liu Y, Wu L, Peng L, Shen B.   +7 more
europepmc   +1 more source

纯氧与空气复苏对缺氧新生大鼠肝细胞凋亡 及Bcl-2和Bax 蛋白表达的影响

Zhongshan Daxue xuebao. Yixue kexue ban, 2009
【目的】 为了比较纯氧与空气复苏对缺氧新生大鼠的复苏效果,探讨新生大鼠肝细胞凋亡及Bcl-265380;Bax蛋白表达在缺氧复苏中的作用65377; 【方法】 采用SD新生大鼠建立缺氧模型,并分组进行纯氧与空气复苏65377;实验分为正常对照组(无预缺氧和复氧实验)65380;纯氧复苏组(PO组) 和空气复苏组(RA组) 65377;取肝组织,HE 染色光镜观察肝组织病理变化,TUNEL法测定肝细胞凋亡指数,免疫组化检测肝组织Bcl-265380;Bax蛋白的表达情况65377;【结果 ...
doaj  

miR-143-3p对人子宫内膜基质细胞增殖活性和炎性因子表达的影响 附视频

Zhongguo shiyan zhenduanxue
目的 评估人脐带间充质干细胞外泌体(hUCMSC-Exos)对米非司酮诱导的子宫内膜基质细胞(hESCs)损伤的逆转作用，并筛选hUCMSC-Exos中发挥作用的microRNA。方法 以米非司酮(mifepristone)、人脐带间充质干细胞来源外泌体(hHUCMSC-Exos)和miRNA单独或联合作用于子宫内膜基质细胞(hESCs),分为mifepristone组、mifepristone+hHUCMSC-Exos组、mifepristone+miRNA组，加入等量生理盐水的hESCs为对照组 ...
doaj   +2 more sources