Zhongguo shiyan zhenduanxue, 2008 目的探讨缺氧诱导因子（HIF-1α）基因治疗家兔肢体缺血模型的疗效。方法在家兔缺血模型的肢体内注射携带/HIF-1α基因的重组腺病毒AdHIF-1α,检测HIF-1α基因在缺血肌组织中表达情况,并观察其生物学特点。实验以携带GFP基因的重组腺病毒AdGFP为对照。结果免疫组化染色均检测到HIF-1α的表达。转AdHIF-1α基因治疗组毛细血管计数及小动脉计数均高于AdGFP转导的对照组 ...
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