Results 11 to 20 of about 38,507 (214)
Radiogenomics-based prediction of <i>KRAS</i> and <i>EGFR</i> gene mutation in non-small cell lung cancer patients. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban目的 非小细胞肺癌(non-small cell lung cancer，NSCLC)患者预后较差，且30%的患者在诊断时已处于晚期。EGFR和KRAS基因突变是影响NSCLC患者预后的重要因素，靶向治疗可显著改善这类患者的生存期。组织活检虽是检测基因突变的金标准，但存在侵入性强、肿瘤异质性导致的取样误差及重复性差等问题。本研究旨在基于放射基因组学特征构建预测NSCLC患者的EGFR和KRAS基因突变的机器学习模型，以期为临床肿瘤精准治疗提供参考依据。 方法 基于美国癌症影像档案(The Cancer ...
Lin J, Yan Z, He L, Zhang H, Xie M.
europepmc +2 more sources
Bio-protocol, 2020 摘要:随机宏基因组测序,也称鸟枪法宏基因组测序,是指对环境样品的总 DNA 进行 高通量测序以获得微生物群落的物种组成及其潜在功能,抑或通过序列拼接和分箱得到 其微生物的基因组。宏基因组测序数据预处理包括两方面:一方面,与转录组、基因组 测序等分析相似的数据质量控制过程,包括质量评估,去除引物、接头及低质量序列; 另一方面,考虑到宿主相关微生物的宏基因组样本易受宿主序列的污染,需要去除宿主 序列并评估宿主比例,以获得高质量的微生物组相关数据以方便开展下游分析。本文主 要介绍 FastQC、MultiQC、
永鑫 刘, 芳梅 刘, 同 陈, 洋 白
semanticscholar +1 more source
Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2015 由于起源部位、细胞类型、基因突变形式的不同，肿瘤可表现出不同的形态。这些因素同时影响肿瘤的治疗效果。虽然已经证实许多基因的改变直接导致了表型的改变，然而，许多肿瘤谱系中复杂分子机制依然未完全阐明。因此，肿瘤基因组图谱（The Cancer Genome Atlas, TCGA）研究网络分析了大量人类肿瘤，以期发现DNA、RNA、蛋白质和表观遗传学水平的分子改变。含丰富数据的结果给我们提供了一个机会，对整个肿瘤谱系的共性、个性及新观点形成一个整体描绘。基因组图谱泛癌计划最先比较了12种肿瘤类型 ...
Kun Zhang, Hong Wang
semanticscholar +1 more source
European Policy Analysis, EarlyView.ABSTRACT This article addresses a critical issue in evidence‐informed policymaking: the challenge of translating knowledge into policy outputs amidst the complex interplay between research and politics. It discusses the concept of “blocked learning,” where individual‐level learning fails to scale up to organizational and policy levels, thus impeding ...
Thenia Vagionaki
wiley +1 more source
Justice in coexistence: Pastoralism and large carnivores on the Qinghai‐Tibet Plateau
People and Nature, EarlyView.Abstract The conflict between livestock husbandry and large carnivore conservation presents significant challenges in grassland ecosystems worldwide. Achieving sustainable coexistence among herders, livestock and large carnivores requires reconciling diverse perspectives and interests through equitable, inclusive and fair processes that address both ...
Yufang Gao, Yue Yu
wiley +1 more source
Multi‐Functional S‐HA/ASTA NPs Coating on Biodegradable ZE21B Alloy for Cerebrovascular Applications
Rare Metals, EarlyView.ABSTRACT Magnesium (Mg) and its alloys have attracted extensive attention of researchers in the field of cerebrovascular implants due to their good mechanical properties and biosafety. However, rapid degradation and delayed endothelialization pose challenges. To address these issues, this study introduces a multifunctional composite coating.
Aqeela Yasin +4 more
wiley +1 more source
Rare Metals, EarlyView.ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang +7 more
wiley +1 more source
Rare Metals, EarlyView.ABSTRACT Internal oxidation has been identified as an effective method for enhancing the strength of AgMg alloys. However, the concurrent occurrence of embrittlement remains inadequately understood, thus limiting their broader application. This study investigates the oxidation behavior of AgMg alloys with Mg concentrations ranging from 1 at% to 7 at ...
Hai‐Cheng Zhu +12 more
wiley +1 more source
The Research of MiRNA-Disease Correlation Prediction [PDF]
, 2016 MiRNA是一类重要的非编码RNA，它在许多的生命活动中扮演着非常重要的角色。经研究证实，miRNA与disease的产生有着密切的联系。本文主要基于生物异构网络和机器学习的方法对miRNA-disease关系进行分析与预测。主要包括以下几个方面的内容： (1)本文详细介绍了当前已提出的miRNA-disease关联预测的主要方法，并且对比了不同方法之间的差异，为生物信息研究人员后续对miRNA-disease关联分析和预测的研究提供参考。现已提出的miRNA-disease关联分析和预测方法 ...
李金金
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High-efficienct Construction of HBV-replicative Stable Cell Lines Based on ALL-IN-ONE Sleeping Beauty Transposon System [PDF]
, 2016 乙型肝炎病毒（HepatitisBvirus，HBV）感染是全球范围内的重要公共卫生问题。HBV为嗜肝病毒，只能在肝细胞中增殖，目前HBV复制与抑制相关的研究大多采用HBV质粒瞬时转染Huh7或HepG2细胞的方法，但在进行药物筛查、病毒制备等需要稳定均一的实验条件时，稳定整合细胞株是更好的选择。HepG2.2.15和HepAD38是当前用于HBV研究的最常用的两株细胞株，其构建策略为随机整合方式，且这两株细胞株均为GenotypeD型。有研究表明，不同基因型乙型肝炎病毒有不同的地理分布特征，在复制 ...
吴勇
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