Results 41 to 50 of about 32,642 (169)
Review of Policy Research, Volume 43, Issue 3, May 2026.ABSTRACT Public appointments shape the top‐level bureaucracy by serving as a gateway for professionals with different profiles, chosen based on different criteria. In general, the literature has been more interested in analyzing appointments based on merit or sponsorship, based on verification of loyalty to the government or technical competence ...
André Vaz Lopes +1 more
wiley +1 more source
糖尿病、冠心病患者ABCA1基因R219K多态性的频率分布特点
Zhongguo shiyan zhenduanxue, 2011 目的旨在探讨我国北方地区汉族人ABCA1基因R219K多态性的频率分布特点,对血脂水平的影响,及其与冠心病、糖尿病和糖尿病合并冠心病的关系。方法采用改良碘化钠法提取基因组DNA,聚合酶链反应限制性片段长度多态性（PCR-RFLP）法分析ABCA1基因R219K多态性。结果正常对照组ABCA1基因R219K多态性RR、RK、KK基因型频率、R等位基因频率、K等位基因频率分别为28.5%、48.6%、22.9%、52.8%、47.2%;糖尿病组分别为29.6%、63.9%、6.5%、61.5%、38.5 ...
许慧, 彭浩, 蒋莹
doaj
The structural analysis and functional study of the interaction between Hepatitis B virus X protein BH3-like domain and Bcl-xL protein [PDF]
, 2016 乙型肝炎病毒(HepatitisBvirus，HBV)感染是全球性的医疗难题，慢性HBV感染可大大增加感染者罹患原发性肝细胞癌(HCC)的风险。HBx蛋白是HBV基因组表达的一种多功能蛋白，在HBV的生命周期及其致HCC过程中发挥重要作用。此前研究表明，HBx可通过其序列中的BH3基序结构域与宿主细胞的Bcl-2/Bcl-XL蛋白相互作用，导致细胞凋亡，并同时提高细胞内Ca2+浓度，进而增强HBV复制，提示这一相互作用可能是HBx发挥功能效应的重要机制。本研究主要对HBx蛋白BH3结构域与Bcl ...
张莹
core
Rare Metals, Volume 45, Issue 4, April 2026.ABSTRACT Nickel‐based superalloys (Ni‐based superalloys) have attracted extensive attention in laser additive manufacturing (LAM) due to their capability to directly fabricate complex and high‐performance structural components. However, the rapid melting and solidification inherent to LAM result in intense thermal cycling, which induces high residual ...
Tianxiang Lin +9 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2014 目的探讨白细胞介素-17F基因多态性与儿童支气管哮喘的相关性,为支气管哮喘的易感基因筛选提供可能的理论依据。方法取本院门诊随诊的60例哮喘患儿设为哮喘组,60例健康儿童设为对照组,两组儿童均于清晨空腹留取外周静脉血2ml,提取全基因组DNA,应用聚合酶链反应及克隆、基因测序方法分析IL-17F基因序列rs763780（H161R）基因多态性。结果 IL-17F基因序列rs763780（H161R）基因型在两组内均未检测到突变型CC,rs763780（H161R）基因型（TC/TT ...
赵宏霞, 刘瑜, 庄哈娜
doaj
Survey of viral diversity in the sediments of South China Sea [PDF]
, 2016 病毒是海洋生态系统中丰度最大，多样性最为丰富的微生物颗粒。海洋沉积物中的病毒丰度相比较海水中，要高1~2个数量级，并且其形态和基因型也更加多样。目前，人们对海洋沉积物中的病毒相关研究还比较少。为了增强对海洋沉积物中病毒的了解，本论文利用荧光显微镜法获得了珠江口沉积物以及南海北部和西部沉积物中病毒的丰度数据，并且通过病毒标记基因（g23&psbA）PCR扩增、克隆文库测序等分子技术获得了沉积物中T4类噬菌体和噬藻体类群的多样性信息。主要的研究结果： （1）荧光显微镜检测结果显示珠江口沉积物中病毒（4.49×
何茂求
core
Rare Metals, Volume 45, Issue 4, April 2026.ABSTRACT Diabetic wound infections are a common complication of diabetes, which severely impact patients' quality of life. Effective treatment of diabetic wound infections remains one major challenge in the clinic, partially due to the formation of bacterial biofilm and antibiotic resistance.
Liang Zhou +8 more
wiley +1 more source
瘦素受体基因Gln223Arg多态性与2型糖尿病合并慢性肾功衰竭关系
Zhongguo shiyan zhenduanxue, 2015 目的探讨瘦素受体基因Gln223Arg多态性与2型糖尿病合并慢性肾功衰竭关系。方法采用聚合酶链反应及限制性片段长度多态性方法(PCR-RFLP)分别测定126例2型糖尿病、108例2型糖尿病合并慢性肾功衰竭和185例对照组样本的瘦素受体基因Gln223Arg的基因型,同时检测各组不同基因型样本的血清瘦素水平。结果 2型糖尿病合并慢性肾功衰竭组与正常对照组瘦素受体基因Gln223Arg基因型频率及等位基因频率比较差异有显著性 ...
李莹 +7 more
doaj
The diversity and physiological characteristics of microbes involved in hydrogen metabolism from deep-sea hydrothermal vent fields [PDF]
, 2015 由微生物介导的发酵产氢由于具有众多的优点，在制氢方面可能具有更大的生产潜力。深海热液系统具有特殊生态环境,与陆地和海洋中的其他生物群落有着根本的区别。本研究针对深海热液环境开展氢代谢菌的研究工作,以期获得特殊生境中的氢代谢微生物资源和氢酶资源。 利用西南印度洋，南大西洋，东太平洋等不同来源的深海热液环境样品，进行了氢代谢菌的分离培养工作。共获得7个高温发酵产氢富集培养物。细菌16SrRNA基因序列分析表明，富集培养物中的主要类群是Calroanaerobacter，Clostridium ...
姜丽晶
core
A Review on Cu‐Based Catalysts for Dehydrogenation of Chemical Hydrides
Rare Metals, Volume 45, Issue 4, April 2026.ABSTRACT Hydrogen (H2) plays a crucial part in the building of clean and sustainable energy systems due to its advantages of being renewable, clean, and pollution‐free. Nevertheless, the secure and effective production‐storage‐transportation of H2 presents critical challenges.
Yixing Luo +6 more
wiley +1 more source