Results 81 to 90 of about 38,507 (214)
Veterinary Dermatology, EarlyView.ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon +5 more
wiley +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2017 【目的】探讨信号转导与转录激活因子4（STAT4）基因rs10181656及rs16833431位点多态性与子痫前期相关性 的关系。【方法】应用聚合酶链反应-限制性片段长度多态性法检测228名子痫前期患者（病例组）和179名健康孕妇（对照 组）的STAT4基因rs10181656 C/G及rs16833431 C/T位点的基因型频率。【结果】①rs10181656位点在病例组中C/C、C/G及G/ G基因型频率分别是35.96％、47.81％及16.23％，而对照组中的三种基因型的频率分别是46 ...
李银广 +5 more
doaj
Functional analysis of Gsc gene in amphioxus during early embryonic development [PDF]
, 2015 文昌鱼是最接近脊椎动物直接祖先的现生动物，是研究脊椎动物发育相关基因功能演化的理想模型。转录因子Goosecoid（Gsc）为Homeobox基因家族重要成员，其mRNA特异表达在脊椎动物胚胎组织者（Organizer）、脊索前板（prechordalplate）等组织区域。在爪蟾中异位表达该基因可产生类似组织者的功能，诱导胚胎第二体轴的形成，该基因还可通过抑制Wnt、BMP等信号活性，参与脊椎动物背腹轴的形成和脑的发育 ...
商留珂
core
ABCA12 Frameshift Deletion in Domestic Cats With Ichthyosis Fetalis
Veterinary Dermatology, EarlyView.ABSTRACT Background Ichthyosis fetalis (IF), also known as harlequin ichthyosis, is a rare and often fatal autosomal recessive congenital skin disorder. It is characterized by thickened, hard skin plaques and deep skin fissures that limit mobility and cause malformations of the eyes, lips and ears.
Jeanna M. Blake +2 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2008 目的研究RhoC基因沉默对肝癌细胞生长和转移潜力的影响。方法基因重组法构建小干扰RNA表达载体,沉默肝癌细胞RhoC基因表达;平板克隆实验检测细胞生长潜力,半定量RT-PCR法检测细胞周期蛋白和MMPs表达水平。结果RNAi组克隆形成百分数显著低于对照组（20.33±5.42%和70.58±10.10 ...
谢淑丽 +5 more
doaj
The Research on the promoter of wsv249 and subcellular localization of WSV249 and WSV403 [PDF]
, 2016 对虾是一种广温广盐性的海产虾类，近年来我国对虾养殖的年产量超过百万吨。对虾养殖产业中细菌性和病毒性疾病严重制约对虾产业的发展。白斑综合症病毒（Whitespotsydromevirus，WSSV）是养殖对虾爆发性传染疾病的主要病害之一。因此对虾疾病尤其是WSSV的侵染机制成为目前研究的热点，病毒极早期基因在病毒感染宿主的过程中起着关键作用，对其进行研究有助于进一步揭示WSSV的侵染机制，为WSSV的防治提供新思路。本研究工作的内容主要包括以下几部分： (1)构建一系列wsv249的启动子249P ...
徐晓敏
core
A Tale of Two Programs? Stigma and Administrative Burdens in CHIP and Medicaid
World Medical &Health Policy, Volume 18, Issue 1, March 2026.ABSTRACT One contributing factor to undersubscriptions is administrative burdens. To explore whether program stigma affects attitudes about administrative burdens, a survey (N = 2204) was fielded to assess differences in attitudes about seven policies decreasing administrative burdens and two policies increasing administrative burdens.
Simon F. Haeder
wiley +1 more source
STAT4基因rs10181656位点的多态性与不明原因复发性自然流产的相关性
Zhongshan Daxue xuebao. Yixue kexue ban, 2017 【目的】探讨信号转导与转录激活因子4（STAT4）基因在不明原因复发性自然流产（URSA）表达及其表达量与 rs10181656位点多态性的关系。【方法】分别采用聚合酶链反应-限制性片段长度多态性法检测332名URSA患者和260名健 康对照者rs10181656位点的基因型频率；应用免疫组织化学技术检测其中的86名URSA患者及77名健康对照者蜕膜STAT4 基因的蛋白表达量。【结果】rs10181656C/G：URSA组中C/C、C/G及G/G基因型频率分别是36.45％、46.99％及16 ...
李银广 +3 more
doaj
The effect of PNPLA3 ploymorphism in the intervention of non-alcoholic fatty liver disease [PDF]
, 2015 研究目的 运动是治疗非酒精性脂肪性肝疾病的一个重要方法，而脂肪滋养蛋白基因（PNPLA3）是非酒精性脂肪性肝疾病的一个重要的基因遗传因子。本研究的目的是为了探讨脂肪滋养蛋白基因的多态性表达是否影响到运动干预非酒精性脂肪性肝疾病的过程。 研究方法 本研究共招募40-65岁中心性肥胖受试者1059人，进行常规体检，并运用彩超检测脂肪肝。并随机抽取476名肥胖受试者进行1H-MRS对其肝内甘油三酯进行定量测定。在这476名肥胖受试者中，随机抽取220人分为三组，强化运动组（先进行6个月的强化运动期 ...
黄竹锋
core
Effects of landscape fragmentation on floodplain fishes as revealed by species–habitat networks
Conservation Biology, Volume 40, Issue 1, February 2026.Abstract How species interact with habitat patches is influenced primarily by habitat configuration (e.g., connectivity) and species’ functional traits. As levels of fragmentation increase, identifying the intricate connections between these components is crucial for biodiversity conservation.
Chen Zhang +8 more
wiley +1 more source