Results 11 to 20 of about 7,319 (164)
Journal of Diabetes, Volume 15, Issue 11, Page 978-986, November 2023., 2023 Highlights Both interleukin‐10 levels and exosomal miR‐let‐7c‐5p levels are correlated with cognitive function in patients with type 2 diabetes mellitus. There is a negative association between interleukin‐10 levels and exosomal miR‐let‐7c‐5p levels in the plasma of patients with type 2 diabetes mellitus. Abstract Background Interleukin (IL)‐10 plays a
Hui Zhang +9 more
wiley +1 more source
Thinking outside the F‐box: how UFO controls angiosperm development
New Phytologist, Volume 240, Issue 3, Page 945-959, November 2023., 2023 Summary The formation of inflorescences and flowers is essential for the successful reproduction of angiosperms. In the past few decades, genetic studies have identified the LEAFY transcription factor and the UNUSUAL FLORAL ORGANS (UFO) F‐box protein as two major regulators of flower development in a broad range of angiosperm species.
Philippe Rieu +3 more
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Journal of Diabetes, Volume 15, Issue 10, Page 817-837, October 2023., 2023 Highlights Type 2 diabetes mellitus (T2DM) is characterized by progressive loss of beta‐cell function and mass. Numerous mechanisms of beta‐cell failure are involved. Preservation and/or enhancement of beta‐cell function is of great importance in delaying the progression of T2DM and the burden of its complications. Accurate evaluation of the effects of
Laure Sayyed Kassem +3 more
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Journal of Diabetes, Volume 15, Issue 10, Page 838-852, October 2023., 2023 Highlights This review outlines the history of miRNA discovery and its major advances in the field of metabolism. We explore the roles of miRNAs in diabetes‐related cognitive impairment. We innovatively propose that miRNAs also act with a certain organ‐targeting specificity due to the organ‐targeting nature of extracellular vesicles, which may aid ...
Yining Chao +5 more
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The shape of aroma: Measuring and modeling citrus oil gland distribution
PLANTS, PEOPLE, PLANET, Volume 5, Issue 5, Page 698-711, September 2023., 2023 Citrus are intrinsically connected to human health and culture, preventing human diseases like scurvy and inspiring sacred rituals. Citrus fruits come in a stunning number of different sizes and shapes, ranging from small clementines to oversized pummelos, and fruits display a vast diversity of flavors and aromas.
Erik J. Amézquita +5 more
wiley +1 more source
Journal of Diabetes, Volume 15, Issue 9, Page 777-786, September 2023., 2023 Highlights Increased glutamate is associated with the development of diabetes. Glutamate increases plasminogen (PLG) levels through glutamate metabotropic receptor 5 activation with various insulin resistance‐related stresses. Glutamate inhibits the conversion of PLG to plasmin by increasing plasminogen activator inhibitor‐1.
Hyo Jung Lee +7 more
wiley +1 more source
Mechanisms of bariatric surgery for weight loss and diabetes remission 减重手术减轻体重和缓解糖尿病的机制
Journal of Diabetes, Volume 15, Issue 9, Page 736-752, September 2023., 2023 Highlights Controversial changes in intestinal hormones after bariatric surgery (BS) were summarized. The changes of signaling proteins involved in insulin resistance and the newly proposed changes in growth differentiation factor 15, exosomes, and extracellular vesicles after BS were elucidated.
Mengsha Yin +6 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2022 目的 探索外泌体来源的miR-21作为胃癌奥沙利铂化疗过程中评价药物敏感性生物标志物的价值。方法透射电镜观察外泌体的形态；构建SGC7901奥沙利铂耐药细胞株，并利用RT-qPCR检测耐药细胞和亲本细胞中miR-21的表达水平；CCK8检测miR-21对SGC7901耐药细胞株增殖抑制率的影响；Western blot检测外泌体的标记蛋白；使用受试者工作特征曲线（ROC）分析奥沙利铂治疗胃癌的过程中miR-21评估药物敏感性的价值。结果miR-21过表达后，亲本细胞对奥沙利铂的敏感性由IC50 16 ...
杜沛, 李婷, 文雯
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Exosomal miR-21-5p derived from metastatic cervical cancer cells promotes cervical cancer invasion and metastasis [PDF]
, 2022 Objective To explore the influence of paracrine function of recurring and metastatic cervical cancer tissues on the spread of cancer cells. Methods Surgical specimens （cancerous and para-cancerous tissues） were obtained from 22 patients with metastatic ...
Yang Xiang, Chen Ye, Zheng Wei, Li Hu, Xia Hong
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间充质干细胞来源的外泌体对2型糖尿病小鼠胰岛功能和炎症因子的影响
Zhongguo shiyan zhenduanxue, 2023 目的 探讨多次输注胎盘间充质干细胞来源的外泌体对2型糖尿病小鼠胰岛功能和炎症因子的影响。方法 应用外泌体提取试剂盒提取胎盘间充质干细胞来源的外泌体；采用高脂高糖饮食及链脲佐菌素诱导2型糖尿病小鼠模型，并随机分为模型组和外泌体治疗组，同时设置正常对照组。外泌体治疗组每隔一天进行尾静脉注射20μg胎盘间充质干细胞来源的外泌体，模型组每隔一天尾静脉注射等体积PBS,连续注射4周。检测正常组、模型组以及外泌体治疗组小鼠的随机血糖、体重及糖耐量水平；酶联免疫吸附实验检测血清中C-肽和胰岛素水平 ...
王振刚 +4 more
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