Results 21 to 30 of about 8,751 (116)

血清外泌体ERG、PSMA在前列腺癌患者中的表达及其预后评估价值

Zhongguo shiyan zhenduanxue, 2021
目的探讨血清外泌体ETS相关基因(ERG)、前列腺特异性膜抗原(PSMA)在前列腺癌(PCa)患者中的表达及其预后评估价值。方法选取2015年7月-2019年7月期间成都上锦南府医院收治的105例PCa患者为癌症组,100例良性前列腺增生患者为疾病组,同期体检的95例健康者为健康组;比较各组间血清外泌体ERG、PSMA的表达水平;根据危险因素分级将PCa患者分成低、中、高危险级别,比较各组PCa患者血清中ERG以及PSMA的表达水平;所有患者均获得1年随访,根据随访结果将患者分为存活组和死亡组 ...
姜庆
doaj  

Lanthanide Nanoparticles With Dual Enzyme Mimetic Activities for Targeted Treatment of Gram‐Negative Bacterial Infections

Rare Metals, Volume 45, Issue 10, October 2026.
ABSTRACT Gram‐negative (G−) bacterial infections, fueled by intrinsic antibiotic resistance stemming from their unique outer membrane architecture, pose a critical global clinical challenge. This study introduces a pioneering dual‐enzyme‐mimetic nanotherapy based on NaYbF4 nanoparticles (NaYbF4 NPs) that achieves synergistic antibacterial and anti ...
Yuxiang Zhang, Wenzhen Liu, Jin Xu, Tao Dai, Yunmei Huang, Xueyuan Chen, Zhuo Chen   +6 more
wiley   +1 more source

Ultrathin MnO2‐PEG‐PD‐L1 Nanosheets Enable Tumor Microenvironment Modulation and NIR‐II Photothermal Immunotherapy for Durable Control of Lung Cancer and Postoperative Recurrence

Rare Metals, Volume 45, Issue 6, June 2026.
ABSTRACT Lung cancer is one of the most common and deadly malignancies worldwide. Although immune checkpoint inhibitors, including PD‐1/PD‐L1 blockers, have benefited a subset of patients, response rates remain limited, and recurrence is frequent because of the immunosuppressive tumor microenvironment (TME), characterized by hypoxia and dysregulated ...
Yi Ma, Lingxi Zhu, Yingran Shen, Yue Liu, Hugang Liu, Kunpeng Zhang, Chao Jiang   +6 more
wiley   +1 more source

Hybrid Probiotic Hydrogel With Curcumin‐Loaded MnO2 Nanoparticles Enhances Diabetic Wound Healing Through Multimodal Microenvironmental Regulation

Rare Metals, Volume 45, Issue 3, March 2026.
ABSTRACT Skin wound injuries are often accompanied by bacterial infections and severe inflammation. Especially, M1‐type macrophages at the wound site can trigger a cascade of inflammatory responses, mediating a vicious cycle of inflammation. Meanwhile, hypoxia further exacerbates vascular damage and constriction in the wound microenvironment, thereby ...
Xianfeng Wang, Yuwen Shangguan, Hao Nan, Lingze Chen, Chencheng Gu, Litao Yan, Huan Li   +6 more
wiley   +1 more source

NIR‐Responsive Nano‐Integrated Magnesium Phosphate Cement Promotes Bone Regeneration via Osteoblast‐Exosome‐Osteoclast Crosstalk

Rare Metals, Volume 45, Issue 2, February 2026.
ABSTRACT The limited osteogenic capacity of magnesium phosphate cement (MPC) has constrained its biomedical applications, underscoring the necessity to develop MPC with enhanced physical properties and bone‐forming capabilities. In this study, a multifunctional MPC system was developed by incorporating zoledronic acid‐loaded near‐infrared (NIR ...
Bin Wang, Shun‐Jie Wu, Xin‐Lin Lu, Yong Ge, Yue Zhang, Zhi‐Xiang Ma, Bin Xu, Paul‐K. Chu, Yan‐Bin Zhao   +8 more
wiley   +1 more source

非小细胞肺癌患者血清外泌体的分离与鉴定

Zhongguo shiyan zhenduanxue, 2016
外泌体最初是由Johnstone等在哺乳动物网织红细胞研究中发现并命名[1-6]。后来的研究发现,外泌体在细胞内形成小囊泡,可以通过胞吐释放到周围环境中,并能够在血液、尿液等多种体液中检测到[7]。外泌体中携带着它本身来源的细胞的多种成分,如蛋白质、DNA、RNA、脂质等[8]。因此,建立稳定的外泌体分离方法是外泌体以及后续相关研究的前提 ...
周玄博, 冯虎, 金鹏, 胡媛媛, 李宁, 陈玉丙   +5 more
doaj  

American highbush cranberry maintains strong population structure despite naturalization of Eurasian relatives in North America

American Journal of Botany, Volume 112, Issue 11, November 2025.
Abstract Premise The proper classification of taxa is often debated, particularly when organisms lack qualitative diagnostic traits. Highbush cranberry taxa (Viburnum spp.) have been the subject of such disputes since their characterization by 18th‐ and 19th‐century botanists. Despite their allopatric distributions—V.
David G. Tork, Neil O. Anderson, Anthony Brusa, Alan G. Smith   +3 more
wiley   +1 more source

Evolution of petal patterning: blooming floral diversity at the microscale

New Phytologist, Volume 247, Issue 6, Page 2538-2556, September 2025.
Summary The flowers of angiosperms are extraordinarily diverse. While most floral variation is visible to the naked eye, this diversity goes beyond the macroscale: Floral organs comprise an underappreciated range of cell types that generate a multitude of patterns across their surfaces and give rise to novel structures.
Erin Doody, Edwige Moyroud
wiley   +1 more source

Well‐resolved phylogeny supports repeated evolution of keel flowers as a synergistic contributor to papilionoid legume diversification

New Phytologist, Volume 247, Issue 1, Page 369-387, July 2025.
Summary The butterfly‐shaped keel flower is a highly successful floral form in angiosperms. These flowers steer the mechanical interaction with bees and thus are hypothesized to accelerate pollinator‐driven diversification. The exceptionally labile evolution of keel flowers in Papilionoideae (Fabaceae) provides a suitable system to test this hypothesis.
Liming Cai, Domingos Cardoso, Lydia G. Tressel, Chaehee Lee, Bikash Shrestha, In‐Su Choi, Haroldo C. de Lima, Luciano P. de Queiroz, Tracey A. Ruhlman, Robert K. Jansen, Martin F. Wojciechowski   +10 more
wiley   +1 more source

CRABS CLAW‐independent floral nectary development in Penstemon barbatus

American Journal of Botany, Volume 112, Issue 6, June 2025.
Abstract Premise Plants secrete carbohydrate‐rich nectar from specialized floral nectary glands to attract pollinators. Arabidopsis and Petunia (rosid and asterid core eudicots, respectively) share genetic control of nectary development requiring activation of CRABS CLAW by euAGAMOUS and PLENA.
Amanda M. Katzer, Carolyn A. Wessinger, Brooklyn M. Anaya, Lena C. Hileman   +3 more
wiley   +1 more source