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血清生物标志物与脑小血管病关系研究进展 Progress of Relationship between Serum Biomarkers and Cerebral Small Vessel Disease

Zhongguo cuzhong zazhi, 2019
目前认为脑小血管病（cerebral small vessel disease，CSVD）的主要机制是血管内皮损伤，而 炎症和血管内皮损伤密切相关，血清中血管内皮损伤相关标志物及炎性标志物是反映炎症损伤血管 内皮最直接、最简便的方法。关于生物标志物的研究为更深入了解CSVD的发生发展机制提供了重要 的途径。目前多项研究表明炎性及血管内皮损伤相关标志物与CSVD的发生、发展关系密切。另外炎症 与CSVD关系也可能受到人种、遗传等因素的影响。本文就血清中血管内皮相关标志物、炎性标志物与 ...
钟曦，王伊龙
doaj   +1 more source

¹¹C-PIB PET在阿尔茨海默病中的应用进展

Zhongguo shiyan zhenduanxue, 2022
阿尔茨海默病(AD)是一种进行性认知功能障碍为核心的中枢神经系统变性病[1],患者不仅存在脑组织结构和功能的异常,还有脑分子代谢改变。阿尔茨海默病生物标志物是评估疾病病理生理学特征的客观量化指标[2],近年来NIA-AA[3]提出AT(N)研究框架,其将生物标志物β-淀粉样蛋白(Aβ)沉积(A)、
李佳霖, 李松涛, 吴凡, 吕书悦, 赵晴, 朴虎男   +5 more
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Predictive performance of Fetal Medicine Foundation first‐trimester screening algorithm for pre‐eclampsia according to conception mode

Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 6, Page 806-814, June 2026.
ABSTRACT Objective To investigate the incidence of pre‐eclampsia (PE) and the predictive performance of the Fetal Medicine Foundation (FMF) first‐trimester PE screening algorithm across pregnancies conceived using assisted reproductive technology (ART), after ovulation induction (OI) and through spontaneous conception (SC).
A. S. L. Kjaer, I. Riishede, L. Rode, R. B. Jensen, K. Pihl, L. Sperling, M. Overgaard, N. G. Pedersen, A. C. Roslev, P. Sandager, A. Tabor, A. Pinborg, C. K. Ekelund, the PRESIDE Study Group, P. Nørgaard, C. Vedel, H. Skov, S. R. Wagner, H. J. Zingenberg, M. R. Andersen, L. Bathum, T. Hilling, C. S. Knudsen, F. S. Jørgensen   +23 more
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Assessing D‐Squame as a Minimally Invasive Technique to Evaluate the Cutaneous Immune Response mRNA in a Dog Model of Canine Atopic Dermatitis

Veterinary Dermatology, Volume 37, Issue 3, Page 353-364, June 2026.
ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon, Marion Mosca, Nadège Milhau, Mélanie Legain, Adrien Idée, Didier Pin   +5 more
wiley   +1 more source

First‐trimester prediction and prevention of preterm pre‐eclampsia in women with chronic hypertension

Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 5, Page 613-622, May 2026.
ABSTRACT Objectives To evaluate the effect of aspirin on gestational age at delivery due to preterm pre‐eclampsia (PE) in women with chronic hypertension (CH), to assess the predictive performance of the Fetal Medicine Foundation (FMF) first‐trimester competing‐risks model for preterm PE in this high‐risk group and to evaluate how parity, previous PE ...
D. L. Rolnik, S. Gil‐Pugliese, A. Syngelaki, E. Bujold, D. Wright, L. C. Poon, K. H. Nicolaides, ASPRE and SPREE Collaborators, C. de Paco Matallana, D. Janga, E. Greco, F. S. Molina, G. Papaioannou, H. Meiri, J. C. Jani, K. Maclagan, K. Tenenbaum‐Gavish, M. Singh, M. Y. Tan, N. O'Gorman, N. Persico, R. Akolekar, S. Cicero, W. Plasencia   +23 more
wiley   +1 more source

Placental insufficiency markers to assess the risk of non‐chromosomal genetic conditions in early‐onset fetal growth restriction

Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 4, Page 492-499, April 2026.
ABSTRACT Objectives To assess the value of placental insufficiency markers for estimating the risk of genetic anomalies in fetuses with isolated early‐onset fetal growth restriction (FGR), defined as an estimated fetal weight ≤ 3rd percentile diagnosed ≤ 28 + 6 weeks' gestation.
M. Armengol‐Alsina, E. Bonacina, M. Dalmau, J. Temprado, I. Valenzuela, M. Codina‐Solà, M. Viñas‐Jornet, C. Rodó, M. Mendoza, Collaborators, A. Casellas, E. Del Barco, A. Brox, M. San Jose, P. Diaz, E. Roldán, B. Serrano, N. Maiz   +17 more
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肾透明细胞癌患者术前血浆GAPDH cfNA水平对诊断及预后的价值

Zhongguo shiyan zhenduanxue, 2021
肾透明细胞癌（ccRCC）是最常见的肾恶性肿瘤[1],但由于缺乏特异性的生物标志物,目前临床上对于ccRCC预后的判断仍然依赖患者或肿瘤的临床和病理特征。寻找一种有效的生物标志物对于ccRCC患者的术后检测以及管理至关重要[2]。循环肿瘤细胞（CTCs）已经被证明在肾细胞癌患者的早期诊断和预后中具有潜在的应用价值[3-4]。
邱实, 陈坤, 衣琳, 于越海
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Lessons from an eradication under multiple constraints of an island rat population of record density

Conservation Biology, Volume 40, Issue 2, April 2026.
Abstract Invasive rats threaten island biodiversity, disrupting ecosystems and endangering native species. Although rat eradication has succeeded on many islands, tropical islands present unique management challenges. Strict regulations and financial constraints on some tropical islands further limit proven eradication methods, complicating rodent ...
Tatiane Micheletti, Thayná J. Mello, Carlos Verona, Vinícius P. O. Gasparotto, Ricardo Krul, Ricardo Araujo, Thali Sampaio, Paulo Rogerio Mangini   +7 more
wiley   +1 more source

中性粒细胞载脂蛋白在感染性疾病应用的临床进展

Zhongguo shiyan zhenduanxue, 2023
人中性粒细胞载脂蛋白(human neutrophil li- pocalin, HNL)以45 kD二硫键连接的同源二聚体存在，是诊断急性细菌感染性疾病的生物学标志物[1-4]。近年来研究发现HNL在感染性疾病中显著升高，HNL作为新型生物标志物在感染性疾病中研究众多，现就此综述如下。1 中性粒细胞载脂蛋白的生物学特性中性粒细胞载脂蛋白是中性粒细胞二级颗粒的主要成分，由180个氨基酸残基组成的相对质量为45 kD的多肽链，
杜丽敏, 张洁, 赵凤芹
doaj  

Ultrasound features in early pregnancy for predicting abnormal karyotype in first‐trimester miscarriage

Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 3, Page 376-384, March 2026.
ABSTRACT Objective To investigate whether combining abnormal morphological features observed on ultrasound in live pregnancies that ended in a first‐trimester miscarriage can predict an abnormal karyotype. Methods This retrospective observational cohort study was conducted at the early‐pregnancy assessment unit at University College London Hospital ...
T. Setty, S. L. Kastora, T. Tellum, J. Farren, E. Jauniaux, D. Jurkovic   +5 more
wiley   +1 more source