Results 131 to 140 of about 24,580 (225)
Association of insulin signaling pathway-related gene polymorphisms and gene-gene interactions with MAFLD in obese children. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2023 Xiao X +5 more
europepmc +1 more source
Study on Multicolor Melting Curve Analysis-based Approaches for the Detection of Gene Polymorphisms Related to Pharmacogenomics [PDF]
, 2017 个体间药物响应的差异性长期困扰着临床，不同病人对同样剂量的同种药物所表现出的疗效和毒副作用往往不同。药物基因组学研究表明，基因多态性对个体药物响应差异起主导作用。伴随药物基因组学的深入研究，药物基因组生物标记物也不断被发现。基因检测是实现个体化用药的重要手段，通过检测相关基因多态性，可指导临床个体化用药，从而提高药物疗效和降低药物不良反应。本文将多色探针熔解曲线分析技术用于药物代谢酶基因CYP2D6、DPYD，药物转运体基因SLCO1B1，药物作用靶点基因ADRB1、APOE、ANKK1 ...
赖小芳
core
International Journal of Applied Linguistics, EarlyView.ABSTRACT Multilingual students in Anglophone universities often operate in survival mode. While translanguaging supports learning, critical gaps remain in understanding how translanguaging pedagogies transform and sustain motivation in English‐dominant contexts.
Melissa Jufenna Slamet, Julie Choi
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2013 目的探讨白细胞介素16（Interleukin-16,IL-16）基因多态性与食管鳞癌的关联。方法采用聚合酶链反应-限制性片段长度多态性方法检测IL-16基因多态性在188例健康对照组和155例食管鳞癌组中的分布,并分析其与临床特征的相关性。结果 rs11556218TG基因型在食管鳞癌组中的频率明显高于其在对照组中的频率（54.8%比42.6%,χ2=6.02,P=0.014）;rs11556218G等位基因在食管鳞癌组中的频率明显高于其在对照组中的频率（32.6%比25.0%,χ2=4.80,P=0.
田维军, 马国昌, 赵金伟, 侯波
doaj
Relationship between NF-κB gene Polymorphisms and Inflammation injure of Hepatitis B [PDF]
, 2017 [目的] 探讨NF-κB基因多态性在乙型病毒性肝炎炎症损伤进展中的影响，为今后有效控制肝脏慢性炎性损伤提供理论依据。 [方法] 于2015年9月-2016年9月收集厦门市中医院肝病科乙肝病毒高载量慢性乙肝住院病例，对所有病例进行问卷调查，了解性别、年龄、HBV感染初次发现年龄、肝脏疾病家族史、吸烟饮酒史等基础资料及乙肝病毒载量、肝脏炎症等级等临床资料，其中慢性乙肝轻型肝炎患者作为对照组，中型及重型肝炎患者作为病例组；采集入组对象空腹外周血5ml，进行病毒载量确认及提取患者DNA样本 ...
王传鹏
core
Basic income trials and the politics of scale: A research agenda
Policy Studies Journal, EarlyView.Abstract The growing popularity of basic income has led to extensive trials of the policy in numerous settings across the world. However, analysis of the politics of basic income, and in particular the political dynamics preceding and resulting from trial programs, lags. In response, we propose a research agenda that uses political scale to investigate
Jurgen De Wispelaere +2 more
wiley +1 more source
肿瘤坏死因子Ⅱ型受体基因多态性与特发性间质性肺炎的相关性研究
Zhongguo shiyan zhenduanxue, 2015 目的研究肿瘤坏死因子Ⅱ型受体（TNFRⅡ）196位点基因多态性与特发性间质性肺炎（IIP）的关联。方法累积收集100例特发性间质性肺炎（IIP）患者,包括特发性肺纤维化（IPF）83例,非IPF-IIP2017例。选取100例年龄、性别、民族、吸烟情况匹配的同地区的健康对照者。应用多聚酶链反应-限制性片段长度多态性技术（PCRRFLP）分别检测入选病例及对照者的肿瘤坏死因子Ⅱ型受体（TNFRⅡ）196位点的基因多态性,并统计分析各基因分布频率与发生IIP、IPF的相关性。结果20IIP组与对照组 ...
李宁 +4 more
doaj
[Association Between Apolipoprotein C-3 SstⅠ Polymorphism and Serum Lipids in Patients With Gestational Diabetes Mellitus]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue Ban, 2023 Tang F +9 more
europepmc +1 more source
c-Src promotes tumor cell proliferation by activating HK2 [PDF]
, 2015 大多数肿瘤细胞即使在氧气充足的情况下依然主要靠糖酵解方式提供能量，这就是著名的Warburg效应，它是肿瘤代谢的一个重要特征。己糖激酶（hexokinase，HK）是糖酵解过程中的第一个限速酶。在哺乳动物体内，HK主要有四种亚型，即HK1、HK2、HK3和HK4，其中HK2与肿瘤的关系最为密切。目前研究表明Warburg效应的发生与原癌基因（如Ras，c-Myc，HIF-1）的过度激活和抑癌基因(如p53)的失活密切相关。c-Src是哺乳动物中最早发现的原癌基因 ...
王随利
core
Scientists in power plays: How substantive were scientists' narratives during the COVID‐19 pandemic?
Policy Studies Journal, EarlyView.Abstract Scientists who provide expert advice must engage with policy processes. Little is known about whether and how scientists deal with the political dynamics of policy processes that are inherent to policymaking. We study this question by building on the policy dimension concept within the Narrative Policy Framework.
Jule Ksinsik, Caroline Schlaufer
wiley +1 more source