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海马干细胞来源的外泌体对血管性痴呆大鼠学习记忆能力改善作用及其机制探究

Zhongguo shiyan zhenduanxue
目的 分析海马干细胞来源的外泌体对血管性痴呆大鼠学习记忆能力改善作用及其机制。方法 取新生SD大鼠海马组织，提取海马干细胞外泌体。成年特殊清洁级(SPF)健康雄性SD大鼠90只，随机分为假手术组、模型组及外泌体组，每组30只，检测各组大鼠学习记忆能力、氧化应激因子水平、海马组织病理学变化、海马组织因子、脑微血管密度以及凋亡相关因子变化。结果 透射显微镜观察到海马干细胞来源外泌体结构呈圆形或椭圆形杯状结构的小囊泡，其结构完整，直径50～100 nm之间；特异性标记蛋白CD9、CD63表达阳性 ...
潘成利, 黄月萍, 薛炬君, 陈曦, 齐丹, 侯晓君, 孙爽, 王喜春, 付宏娟   +8 more
doaj  

[Hypertension exacerbates postoperative learning and memory impairment in rats possibly due to UCP2 downregulation-mediated mitochondrial dysfunction]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Liu L, Gong M, Liao G, Zhao W, Fu Q.
europepmc   +1 more source

[Yigong San improves learning and memory functions of APP/PS1 transgenic mice by regulating brain fluid metabolism]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Zeng J, Hua L, Yang Y, Zhang X, Wei J, Li L.   +5 more
europepmc   +1 more source

知母皂苷元对体外培养皮层神经元树突发育的影响及信号转导机制 [PDF]

目的探讨知母皂苷元(Sarsasapogenin,SAR)对大脑皮层神经元树突发育的促进作用及其信号转导机制。方法选用出生0～24 h的Sprague-Dawley(SD)大鼠乳鼠,取皮层神经元进行体外细胞培养,4 d后用于实验。倒置相差显微镜测量培养神经元树突分支总长度(TDBL)、一级树突数目(PDN)、最大分支级数(MBO)和神经元胞体面积。West-ern blot法观察神经元p-PDK1、p-Akt473及p-mTOR蛋白表达。结果形态学观察结果显示SAR(10、30、100μmol.L-1 ...
张永兴, 王金宁, 董燕, 隋海娟
core  

[Effects of 40 Hz light flicker stimulation on hippocampal-prefrontal neural activity characteristics during working memory tasks in Alzheimer's disease model rats]. [PDF]

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
Liu S, Wang L, Li S, Xu G.
europepmc   +1 more source

海马干细胞来源的外泌体对血管性痴呆大鼠学习记忆能力改善作用及其机制探究 附视频

Zhongguo shiyan zhenduanxue
目的 分析海马干细胞来源的外泌体对血管性痴呆大鼠学习记忆能力改善作用及其机制。方法 取新生SD大鼠海马组织，提取海马干细胞外泌体。成年特殊清洁级(SPF)健康雄性SD大鼠90只，随机分为假手术组、模型组及外泌体组，每组30只，检测各组大鼠学习记忆能力、氧化应激因子水平、海马组织病理学变化、海马组织因子、脑微血管密度以及凋亡相关因子变化。结果 透射显微镜观察到海马干细胞来源外泌体结构呈圆形或椭圆形杯状结构的小囊泡，其结构完整，直径50～100 nm之间；特异性标记蛋白CD9、CD63表达阳性 ...
doaj   +2 more sources

[Application and progress of artificial intelligence agents in drug development]. [PDF]

Zhejiang Da Xue Xue Bao Yi Xue Ban
Zhao D, Hsieh C.
europepmc   +1 more source

[Identification of efferocytosis-related genes in osteoarthritis and prediction of traditional Chinese medicines based on bioinformatics and machine learning]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Xiang K, Zhang X, Li Z, Xu Z, Liu S, Chai Y.   +5 more
europepmc   +1 more source

[ResLSTM-TemporalSE: an automated classification model for multi-lead ECG signals]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Qu M, Fu R.
europepmc   +1 more source

[<i>Qixiong Zuogui</i> Granules enhance synaptic plasticity in aging rats by regulating the BDNF/TrkB signaling pathway]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Wang Q, Zhao X, He Y, Liu F, Zhang Y.
europepmc   +1 more source