Results 31 to 40 of about 146,209 (140)
Zhongshan Daxue xuebao. Yixue kexue ban, 2023 目的研究丁香酚对人脐带间充质干细胞（HUC-MSCs）抑制肝星状细胞（HSCs）炎性活化以及巨噬细胞促炎表型作用的影响及其相关机制；方法体外培养并鉴定HUC-MSCs，并采用MTT法评估丁香酚对HUC-MSCs的毒力作用；体外划痕实验探究丁香酚对HUC-MSCs迁移能力的影响；丁香酚处理HUC-MSCs后的旁分泌产物（EU-MSCs-CM）、HUC-MSCs旁分泌产物（MSCs-CM）处理经TGF-β1处理活化的LX-2细胞，WB实验检测LX-2的α-SMA、COL1A1、Smad2/3、p-Smad2/
吴逐宇, 汪显耀, 陈艳, 何志旭
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Zhongguo shiyan zhenduanxue, 2021 目的研究D-缬氨酸对巨噬细胞M1极化的影响。方法在不同浓度的D-缬氨酸情况下,通过CCK-8方法测定分析细胞毒性,利用实时PCR分析多个基因的mRNA表达。然后通过Elisa方法检测IL-6,IL-1β,TNF-α的蛋白表达,使用荧光显微镜分析iNOS表达。结果 50mM D-缬氨酸对巨噬细胞没有细胞毒性,D-缬氨酸在mRNA和蛋白质水平下调IL-6,IL-1β和TNF-α的表达,细胞中iNOS也下调明显。结论 D-缬氨酸抑制RAW264.7巨噬细胞中LPS/IFN-γ诱导的M1巨噬细胞极化。
倪宇昕, 王勇, 邓艳芳
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Rare Metals, Volume 45, Issue 6, June 2026.ABSTRACT The poor soft tissue integration around titanium implants creates a microgap that serves as a pathway for pathogen invasion, resulting in infection, inflammation, and the progression of peri‐implantitis. As the implant’s transmucosal component, the abutment determines the degree of peri‐implant soft tissue attachment.
Xuan Li +7 more
wiley +1 more source
Biodegradable Mg Alloys: Enhancing Anti‐tumor Immunity in Cancer Therapy
Rare Metals, Volume 45, Issue 4, April 2026.ABSTRACT Magnesium (Mg) alloys, as biodegradable metallic materials with excellent biocompatibility and mechanical properties, demonstrate significant advantages. In the field of immunotherapy, they present a promising potential option for enhancing therapeutic outcomes and hold broad prospects for application.
Can Feng +8 more
wiley +1 more source
Zhongguo cuzhong zazhi, 2023 动脉粥样硬化是冠状动脉、脑血管和外周动脉疾病的重要病理基础，动脉血管壁多种类型的细胞（如皮细胞、血管平滑肌细胞、巨噬细胞、淋巴细胞等）共同参与脂质驱动的血管炎症和动脉粥样硬化斑块形成的病理过程。动脉粥样硬化斑块内巨噬细胞具有高度异质性和复杂性，不同巨噬细胞亚群执行不同的功能，调控血管炎症反应的方向。单细胞技术是全面无偏倚分析细胞异质性的理想工具。最新单细胞研究解析了动脉粥样硬化斑块复杂的细胞和分子组成，证实斑块微环境中细胞的高度适应性和可塑性。通过高通量、高分辨率单细胞测序技术分析斑块内巨噬细胞的状态 ...
赵曼曼, 程丝, 李嫣然, 李昊, 王拥军
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Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Skin wound injuries are often accompanied by bacterial infections and severe inflammation. Especially, M1‐type macrophages at the wound site can trigger a cascade of inflammatory responses, mediating a vicious cycle of inflammation. Meanwhile, hypoxia further exacerbates vascular damage and constriction in the wound microenvironment, thereby ...
Xianfeng Wang +6 more
wiley +1 more source
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu +5 more
wiley +1 more source
Multi‐Functional S‐HA/ASTA NPs Coating on Biodegradable ZE21B Alloy for Cerebrovascular Applications
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Magnesium (Mg) and its alloys have attracted extensive attention of researchers in the field of cerebrovascular implants due to their good mechanical properties and biosafety. However, rapid degradation and delayed endothelialization pose challenges. To address these issues, this study introduces a multifunctional composite coating.
Aqeela Yasin +4 more
wiley +1 more source
Nogo-B通过Rac1 GTPase激活途径调控巨噬细胞的胞葬功能
Zhongguo shiyan zhenduanxue, 2018 目的巨噬细胞的胞葬功能对维持机体生长发育及内环境稳定至关重要。本研究拟探讨,Nogo-B是否对巨噬细胞的胞葬功能具有调控作用及其可能机制。方法将J774A.1小鼠巨噬细胞株分为siRNA阴性对照组与Nogo-B siRNA干扰组,采用紫外线法诱导HL60细胞凋亡。分别以绿色与红色荧光celltracker对巨噬细胞与凋亡细胞进行染色并共同孵育,免疫荧光显微镜下观察巨噬细胞对凋亡细胞的吞噬指数变化;对巨噬细胞给予凋亡细胞刺激,于刺激5、10及15min采集巨噬细胞提取蛋白,谷胱甘肽巯基转移酶 ...
张英 +5 more
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四川大学学报. 自然科学版, 2002 为探讨牙周炎龈组织中巨噬细胞具有多功能效应细胞与信息细胞的作用 ,对 19例牙周炎患者龈组织中 ,观察了巨噬细胞的超微结构及与其他免疫细胞形态学改变的相互关联 ,其结果为 :巨噬细胞除有吞噬作用、物质代谢作用外 ,活化的巨噬细胞可激活淋巴细胞转化为淋巴母细胞 ;诱导B细胞增殖、分化为浆细胞合成免疫球蛋白 ;刺激中性粒细胞形成免疫性吞噬 ;与其他免疫细胞相互作用 ,产生特异性免疫反应 .作者根据巨噬细胞形态学的改变 ,必然引起细胞功能的改变这一事实 ...
冯利, 冯洁, 王春华, 王玉霞
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