Results 21 to 30 of about 24,445 (119)

An Ultrasmall Strontium‐Loaded Polydopamine Nanoformulation for Near‐Infrared‐Enhanced Periodontitis Therapy via Photodynamic Gas‐Promoted Antibacterial and Bone Repair

open access: yesRare Metals, Volume 45, Issue 3, March 2026.
ABSTRACT Periodontitis is a chronic infectious oral disease triggered by periodontopathogenic bacteria, resulting in the progressive inflammation and destruction of the tissues surrounding teeth. To achieve reprogramming of the infectious microenvironment for periodontitis therapy, a nanoformulation was proposed by loading polydopamine (PDA) with ...
Hao Liang   +14 more
wiley   +1 more source

Engineering a Tumor‐Targeted MgH2@Lip/PD‐L1 Nanoplatform for Synergistic Hydrogen Therapy and Immune Activation

open access: yesRare Metals, Volume 45, Issue 3, March 2026.
ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu   +5 more
wiley   +1 more source

Multiple pregnancy with complete hydatidiform mole and coexisting normal fetus: systematic review and meta‐analysis of clinical outcomes from non‐randomized studies

open access: yesUltrasound in Obstetrics &Gynecology, Volume 67, Issue 3, Page 272-282, March 2026.
ABSTRACT Objective Complete hydatidiform mole and coexisting normal fetus (CHMCF) is a rare condition for which there is significant heterogeneity in diagnosis, counseling and management of complications. The objective of this study was to summarize the prevalence of clinical outcomes in reported cases of CHMCF.
N. Salmeri   +8 more
wiley   +1 more source

糖尿病心血管并发症患者AGEs与NO的变化特点及其临床意义

open access: yesZhongguo shiyan zhenduanxue, 2006
目的探讨糖尿病(DM)时AGEs与NO的关系,以及AGEs与NO在糖尿病心血管并发症中的意义。方法用ELISA法检测研究对象血清中AGEs的水平,用硝酸还原酶法检测研究对象血清中NO含量。结果①糖尿病患者清AGEs水平高于健康对照组,且糖尿病有心血管并发症组AGEs明显高于无心血管并发症组。②糖尿病患者血清NO水平低于健康对照组,且糖尿病有心血管并发症组NO明显低于无心血管并发症组。③AGEs与NO呈负相关。结论血中高浓度的AGEs可能通过灭活NO等机制与NO共同参与DM心血管并发症的发生发展。
赵华   +4 more
doaj  

Multi‐Functional S‐HA/ASTA NPs Coating on Biodegradable ZE21B Alloy for Cerebrovascular Applications

open access: yesRare Metals, Volume 45, Issue 2, February 2026.
ABSTRACT Magnesium (Mg) and its alloys have attracted extensive attention of researchers in the field of cerebrovascular implants due to their good mechanical properties and biosafety. However, rapid degradation and delayed endothelialization pose challenges. To address these issues, this study introduces a multifunctional composite coating.
Aqeela Yasin   +4 more
wiley   +1 more source

糖尿病慢性并发症凝血功能变化的临床意义

open access: yesZhongguo shiyan zhenduanxue, 2014
目的观察糖尿病慢性并发症患者血浆血栓调节蛋白(TM),蛋白C(PC),蛋白S(PS),抗凝血酶(AT-Ⅲ)的变化,了解这些因子在糖尿病慢性并发症凝血功能变化中的意义。方法按糖尿病常见并发症分为4组:糖尿病无并发症20例,糖尿病肾病(DN)20例,糖尿病视网膜病变(DR)20例,糖尿病足(DF)20例,以及年龄相匹配的健康正常人20例作为对照组,分别应ELISA方法测定血浆TM浓度,日本sysmex 6000全自动凝血分析仪测定PC,PS,AT-Ⅲ浓度。结果各血浆TM,PC,PS水平均明显高于正常对照组 ...
邵晶莹   +5 more
doaj  

脓毒症合并休克患者不同部位经皮血氧饱和度与血气分析中动脉血氧饱和度的差异分析

open access: yesZhongguo shiyan zhenduanxue, 2020
所谓"脓毒症"指的就是由于细菌感染而引起肺部、胆管等全身任意一个部分出现炎症的综合征,脓毒症患者常合并休克等严重并发症[1,2]。对于脓毒症合并休克患者而言,其体温、心率、外周血细胞数量以及呼吸频率等指标均会发生异常反应,严重影响患者的正常生活[3,4]。此外,脓毒症合并休克也会导致血氧饱和度等指标发生变化[5]。但是 ...
刘小明   +5 more
doaj  

老年患者胆总管结石ERCP术后并发重症急性胰腺炎相关因素分析

open access: yesZhongguo shiyan zhenduanxue, 2021
经内镜逆行性胰胆管造影术(ERCP)广泛应用于胆胰系统疾病的诊断与治疗中,具有操作简便、创伤小、并发症少、患者住院天数少等优点。ERCP是指将内镜插至十二指肠降部,并经十二指肠乳头开口或瘘口等部位插入相关器械,向胰胆管内注入造影剂后进行诊治的操作。ERCP术后胰腺炎(PostERCP Pancreatitis,PEP)是ERCP术后最常见的并发症,且少部分轻中度胰腺炎可转化为重症急性胰腺炎。现在人口老龄化加重,有研究发现老年患者ERCP术后并发严重并发症的发生率与死亡率均高于中青年患者[1 ...
刘艺, 张昊, 张斌
doaj  

Smart Biomaterials and Dressings for the Treatment of Chronic Inflammatory Skin Diseases

open access: yesRare Metals, Volume 45, Issue 2, February 2026.
ABSTRACT Chronic inflammatory skin diseases, encompassing immune‐inflammatory conditions and infection‐associated dermatoses, pose significant clinical challenges due to high prevalence, recurrence, and therapeutic resistance, affect over 30% of the global population.
Zehao Lan   +5 more
wiley   +1 more source

Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment

open access: yesRare Metals, Volume 45, Issue 2, February 2026.
ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang   +9 more
wiley   +1 more source

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