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Implications of Tobacco Use on Pathogen‐Driven Diseases: A Public Health and Policy Perspective
World Medical &Health Policy, Volume 17, Issue 3, Page 468-474, September 2025.ABSTRACT The tobacco epidemic remains one of the most significant global public health challenges, responsible for over 8 million deaths annually, with a substantial portion occurring among non‐smokers exposed to second‐hand smoke. While cigarette smoking remains the most prevalent form of tobacco use worldwide, the rise of electronic nicotine delivery
Nadine Kabbani, James L. Olds
wiley +1 more source
Updated insights into the molecular pathogenesis of canine atopic dermatitis
Veterinary Dermatology, Volume 36, Issue 4, Page 375-384, August 2025.Abstract Atopic dermatitis (AD) is a common and chronic inflammatory skin disease with frequent relapses. The genomics revolution has greatly contributed and revolutionised our knowledge of human AD; understanding the molecular skin fingerprint of AD and associated pathogenic immune pathways has led to preclinical assessments of several novel ...
Frane Banovic
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2017 MicroRNA（微小RNA,miRNA）是一类大小约19-25nt的短链非编码RNA,人类已发现1000多种miRNA,参与调节了人60%以上的人类基因[1]。MiRNA由RNA20polymeraseⅡ转录成较长的初级产物pri-miRNA,然后在Drosha和DGCR8酶的作用下,剪切为约70nt并具有独特发卡结构的premiRNA ...
王小昆, 张玉成, 吴晓冬
doaj
, 2008 由于对真核生物基因转录延伸期研究的忽视,现有的真核生物基因转录理论存在种种的偏颇。然而,新近的研究发现却使人们逐渐认识到,真核基因转录延伸阶段其实是真核细胞调节基因转录的一个高度有序、而又极为复杂的调控平台。本文尝试对近年来真核生物基因转录延伸领域的研究进展,包括转录延伸与mRNA加工的偶联、基因转录延伸调控的分子机理以及转录延伸调控对发育和应激反应产生的影响 ...
刘敏, 艾南平, 陈瑞川
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Veterinary Dermatology, Volume 36, Issue 1, Page 14-23, February 2025.Background – Bacterial identification and antimicrobial susceptibility testing is an important step in timely therapeutic decisions for canine superficial bacterial folliculitis (SBF), commonly caused by Staphylococcus pseudintermedius. Next‐generation sequencing (NGS) offers the appeal of potentially expedited results with complete detection of ...
Kimberly Smart +4 more
wiley +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2002 【目的】探讨一氧化氮(NO)在舌鳞癌血管生成中的作用。【方法】原位杂交检测68 例舌鳞癌活检组织常规石 蜡包埋标本中诱导型一氧化氮合酶(iNOS)m RNA 的表达, 分别以血管内皮生长因子(VEGF)多克隆抗体、Ⅷ 因子单克隆抗体 免疫组化检测上述舌鳞癌标本中VEGF 的表达和微血管密度(M VD)。【结果】①舌鳞癌iNOS mRNA 表达阳性组微血管密度 显著高于阴性组(P
曾曙光
doaj
De-ubiquitinating Enzyme A20 block HIV-1 gene transcription cooperatively activitated by HMBA and Prostratin [PDF]
, 2013 艾滋病之所以难治愈的一个关键问题，在于HIV病毒以潜伏状态存在于宿主细胞内，躲避药物的靶向作用。因此，激活潜伏的病毒，再让其暴露于药物之下，就可以有望杀死所有病毒从而治愈艾滋病。而激活潜伏状态的病毒，关键在于激活HIV-1基因的转录。我们将HIV-1启动子区域和荧光素酶报告基因形成融合基因转染HeLa细胞，建立稳定表达融合基因的细胞株。采用HMBA和Prostratin联合用药的处理方式，极大激活了HIV-1基因的转录，达到激活HIV-1的潜伏的目的。为了探索这两种药物协同激活HIV ...
王会平
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The future directions of artificial intelligence in the biological benefit-dominated diagnosis and treatment of pancreatic cancer [PDF]
Pancreatic cancer is a high malignant tumor with insidious onset, early metastasis, and extremely poor prognosis. How to improve the early diagnosis and the prognosis of the patients is the current research focus.
QI Zhong, XING Ying, CHENG Shi
core +1 more source
International Journal of Endocrinology, Volume 2025, Issue 1, 2025.Background Epidemiological studies suggest a potential link between diabetes mellitus (DM) and osteoarthritis (OA), but the molecular mechanisms underlying this association remain unclear. Identifying these mechanisms is crucial for developing targeted therapies for diabetic patients with OA.
Jian Ding +5 more
wiley +1 more source
The function of four lifespan-related genes in Caenorhabditis elegans [PDF]
, 2014 线粒体中折叠环境的变化通过影响核基因的编码诱导线粒体的伴侣蛋白的表达，从而引起线粒体非折叠蛋白反应(UPRmt)。这些反应将会导致蛋白折叠能力的增加，抑制蛋白进入细胞或者抑制蛋白表达，增加蛋白质降解水平，潜在的引起细胞死亡。在秀丽隐杆线虫线粒体中，非折叠蛋白反应（UPR）通过影响dve-1、UBL-5和ZC376.7的诱导和定位，激活伴侣分子如HSP60的表达，所以dve-1可以调控UPR通路，调节线粒体功能，从而影响细胞寿命。DVE-1在线虫胚胎发育和线粒体形态的维持方面都发挥着重要的作用 ...
陈帅帅
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