Results 11 to 20 of about 7,549 (173)
Effect of type 2 diabetes on A disintegrin and metalloprotease 10 2型糖尿病对解整合素金属蛋白酶10表达的影响
Journal of Diabetes, Volume 14, Issue 6, Page 394-400, June 2022., 2022 Highlights a disintegrin and metalloprotease 10 (ADAM10), a sheddase responsible for the cleavage of a variety of cell surface molecules, has been implicated in the pathogenesis of Alzheimer disease, atherosclerosis, and inflammatory and neoplastic disorders, and systemic ADAM10 concentration may potentially be used as a prognostic biomarker. Our study
Sum Lam +3 more
wiley +1 more source
Journal of Diabetes, Volume 13, Issue 7, Page 562-571, July 2021., 2021 Highlights Several psychiatric disorders were associated with levothyroxine therapy (LT4). Depression, anxiety disorders, and attention‐deficit/hyperactivity disorder showed the strongest relation to LT4. Thyroid autoimmunity itself (no LT4) was not associated with psychiatric disorders.
Alexander Eckert +9 more
wiley +1 more source
Journal of Diabetes, Volume 13, Issue 2, Page 143-153, February 2021., 2021 Highlights A machine learning model can significantly predict imminent development of islet autoimmunity based on environmental, genetic, and metabolic features. The machine learning algorithm feature selection identified type 1 diabetes‐associated single nucleotide polymorphisms from The Environmental Determinants of the Diabetes in the Young (TEDDY ...
Bobbie‐Jo M. Webb‐Robertson +10 more
wiley +1 more source
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT The escalating issue of drug‐resistant pathogens, largely driven by the overuse of conventional antibiotics, has become a significant global health threat. Developing alternative therapeutic strategies and fabricating natural biological enzyme materials that mimic the high efficiency, selectivity, and mild‐operating conditions of natural ...
Shuai He +11 more
wiley +1 more source
Functional Ecology, Volume 39, Issue 5, Page 1274-1287, May 2025.Read the free Plain Language Summary for this article on the Journal blog. Abstract Interactions between plants and soil microorganisms in the rhizosphere are vital for maintaining the nutrient cycle and stability of terrestrial ecosystems. Nitrogen, closely related to carbon (C) cycling and ecosystem productivity, undergoes transformation by soil ...
Ru Wang +9 more
wiley +1 more source
, 2019 铅（Pb）是环境中最普遍的重金属污染物之一，不仅直接毒害土壤生物，破坏生态结构，还可以通过食物链迁移转化，危害人体健康，因此Pb污染的治理迫在眉睫。大型真菌具有强的金属富集能力及较高的相对年生物量，因此在对Pb污染的修复中有一定优势。本文以双孢蘑菇菌丝为研究对象，采用马铃薯葡萄糖琼脂培养的方法，研究不同浓度Pb胁迫对双孢蘑菇菌丝体的生长状况、形态以及机体内抗氧化酶系统的影响。结果表明，在实验浓度下Pb对双孢蘑菇菌丝体的生长率无显著性影响，且菌丝体中Pb含量随着培养基中Pb浓度的增加而升高，达到10.40
严重玲 +5 more
core +1 more source
Study on Alleviation Mechanism of Hydrogen Sulfide on Copper Stress in Rice Seedlings [PDF]
, 2015 硫化氢（hydrogensulfide,H2S）是继一氧化氮（nitricoxide,NO）、一氧化碳和(carbonmonooxide,CO)之后被广泛关注的气体信号分子，低浓度的H2S在动物、植物和微生物中被证实参与了众多生理生化过程，调节了有机体的生长发育。H2S在植物应对盐害、干旱、重金属胁迫、冷热胁迫中发挥重要作用，增强植物对逆境的抵抗力。 铜污染是环境污染中不容忽视的一类重金属污染。本文中，我们以水稻（Oryzasativa）为材料，研究了H2S对铜胁迫的影响。结果显示低浓度的H2S ...
尹珊珊
core
Physiological and Proteomic Analyses in Responses of Mangrove Plant Kandelia obovata Seedling Leaves to Submergence Stress [PDF]
, 2016 水淹是限制多数植物生长和发育的重要限制因子。红树植物是生活在滨海湿地的一类对水淹具有较高耐性的木本植物。近年来，在对红树林湿地的围垦和鱼塘养殖的开发过程中经常会造成对红树植物的严重水淹，甚至是长时间、整株植物的被淹（特别是对幼苗）。然而，红树植物对这种长时间、全淹胁迫的响应仍有待研究。在本研究中，基于蛋白质组学技术，我们采用红树植物秋茄（Kandeliaobovata）幼苗为实验材料，来探究红树植物秋茄耐受长时间、全淹胁迫的生理响应和分子机制。主要研究结果如下: （1）秋茄幼苗持续全淹处理 ...
李赞
core
Study on Embryotoxicity and Bioaccumulation of the Combined Exposure of Typical Antibiotics in Oryzias Melastigma Embryos [PDF]
, 2015 抗生素以其优良的抗菌作用，被人类广泛地使用，致使其以各种途径，大量地进入到自然环境中，尤其是水环境中。其中，磺胺类和氟喹诺酮类药物因其广谱的抗菌性而被大量使用，因此成为水环境中检出率最高、检出浓度最大的两类抗生素。目前，环境中抗生素的研究主要集中于痕量检测，对于水生生物毒性研究多针对于大型溞、浮萍、月芽藻等低等水生生物，而对低剂量、长期暴露下抗生素对鱼类的生理毒性效应，及其在生物体内的富集研究相对较少，其在水环境中潜在的生态毒理效应尚未有明确的评价，有必要对相关的生态毒理数据进行完善，同时 ...
王耿丽
core
Zhongguo shiyan zhenduanxue, 2014 肺部疾病发病机制复杂,最近的研究发现,除免疫反应外,还存在氧化/抗氧化失衡。经典的酶抗氧化系统能够减轻氧化应激引起的肺损伤,但发挥作用的程度及方式仍不足。血红素氧合酶-1（heme oxygenase-1,HO-1）是新近发现的一种最广泛存在的抗氧化酶,通常呈低水平表达,当受到伤害性刺激后水平可明显升高,在肺的适应性和保护性反应中起着重要作用 ...
廉玉兰, 袁宝军
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