Results 11 to 20 of about 10,003 (153)
Journal of Diabetes, Volume 15, Issue 7, Page 607-621, July 2023., 2023 Highlights The CD4 T cells of type 1 diabetes (T1D) patients particularly having HLA‐DRB1*03‐DQA1*05‐DQB1*02 haplotype are reactive against a particular region of the glutamic acid decarboxylase (GAD65) protein. GAD65 peptides encompassing 288–308 amino acid positions (peptide pool 2) may be favored by the HLA‐DR3 molecule for presentation to CD4 T ...
Neihenuo Chuzho +7 more
wiley +1 more source
Treatment of equine sarcoids using recombinant poxviruses expressing feline interleukin‐2
Veterinary Dermatology, Volume 32, Issue 3, Page 283-e77, June 2021., 2021 Background – Interleukin (IL)‐2 stimulates antitumour immunity and is successfully used for the treatment of different neoplasias. Hypothesis/Objectives –Canarypox virus locally expressing feline IL‐2 is safe and can be used to treat equine sarcoids. Conclusions –Treatment of equine sarcoids with recombinant canarypox virus expressing feline IL‐2 seems
Johanna Loschelder‐Ostrowski +4 more
wiley +1 more source
Developmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019 目的 本国际临床指南由欧洲残疾儿童学会（the European Academy of Childhood Disability，EACD）牵头制定，旨在解决发育性协调障碍（developmental coordination disorder，DCD）的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题，通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础，以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类，最终转化为指南建议。并由国际 ...
Jing Hua +6 more
wiley +1 more source
UVA Assisted 4-Thiothymidine for Cancer Treatment [PDF]
, 2016 This article reviews the developments of 4-thiothymidine analogues, assisted with UVA light, as a novel cancer therapy. First, the key points on synthetic chemistry, photochemistry and cellular toxicity of 4-thiothymidine are summarized.
Feng, Luo +3 more
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Advances on the Effect of Processing Technology on Structure Activity Relationship and Solution Behavior of Polysaccharides [PDF]
, 2021 Polysaccharides are natural polymers formed by more than 10 monosaccharide molecules connected by glycoside bonds.The structure is the basis of the biological activity of polysaccharides.The structure of polysaccharides is complex and diverse, and its ...
FAN Liu-ping +5 more
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Research Progress on the Synthesis and Bioactivities of Indole-3-glyoxylamide Derivatives [PDF]
, 2017 综述了吲哚-3-乙醛酰胺类化合物(ID)的合成及生物活性的研究进展。ID具有抗肿瘤、抗病毒、抗菌、抗炎、腺苷受体功能调节、缓解疼痛和抗类风湿关节; 炎等多种生物活性,在药物化学领域有广泛应用。ID的合成方法主要为:吲哚母核与乙酰氯在乙醚(或THF)中于室温反应1; h制得含草酰氯结构的中间体;中间体与取代胺基化合物和二异丙基胺乙基胺反应合成ID。并对ID未来的应用作了简要展望。The synthesis and bioactivities of indole-3-glyoxylamide ...
方美娟, 王飞, 胡鸿雨, 赵胜贤
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Optimization of Extraction Process and Evaluation of Antioxidant and Antitumor Activities of Total Flavonoids from Scutellaria barbata [PDF]
, 2023 The purpose of this experiment was to optimize the extraction process of total flavonoids from Scutellaria barbata and to evaluate the antioxidant and antitumor activity of total flavonoids. A single factor experiment combined with a response surface Box-
Min WEN +4 more
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Chemical constituent and biological activity research of the small polar substances from Vitis thunbergii var. taiwaniana [PDF]
, 2015 小叶山葡萄(Vitisthunbergiivar.taiwaniana)是葡萄科葡萄属植物，主要分布于台湾，本文对小叶山葡萄的化学成分以及其抗氧化、抗炎和抗肿瘤活性进行了研究。 利用大孔吸附树脂、正相硅胶柱色谱、ODS中低压柱色谱、SephadexLH-20凝胶柱色谱、薄层色谱、分析型和制备型高效液相色谱等分离方法，从小叶山葡萄60%乙醇提取部位大孔树脂柱95%乙醇洗脱部位共分得20个单体化合物，通过理化性质的分析比较、核磁共振波谱以及高分辨质谱等对化合物的结构进行了鉴定 ...
姜超
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New Advances of Degradable Magnesium‐Based Metal Biomaterials in the Field of Orthopedics
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Based on their outstanding biomechanical properties and superior osteogenic activity, magnesium (Mg) and its alloys have been extensively investigated for their biocompatibility and therapeutic efficacy in treating fractures and bone defects.
Jia‐Nan Yu +8 more
wiley +1 more source
Chemical constituents from Wedelia prostrata and their cytotoxicity activity [PDF]
, 2016 卤地菊（Wedeliaprostrata（Hook.etArn.）Hemsl.）为菊科蟛蜞菊属植物。对蟛蜞菊属植物研究调查表明，其主要含有二萜，倍半萜，黄酮和有机酸等化学成分。二萜尤其是对映-贝壳杉二萜类是蟛蜞菊属植物的主要活性成分，具有抗菌、抗病毒、抗氧化、抗癌、抗血管生成等生物活性。 本文首先用石油醚、乙酸乙酯、正丁醇三种不同极性的溶剂依次对卤地菊的乙醇提取物进行萃取，初步得到三个萃取部位，对卤地菊石油醚部位进行系统的化学成分研究，采用硅胶柱层析、聚酰胺柱层析、葡聚糖凝胶柱层析 ...
林剑虹
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