Results 21 to 30 of about 7,164 (135)

某院临床路径前后外科抗菌药物应用分析 [PDF]

open access: yes, 2012
目的:比较临床路径前后某院外科Ⅰ类切口手术患者抗菌药物使用情况及合理性。方法:收集某院外科Ⅰ类切口手术76例实施临床路径组与88例非临床路径组病历资料,包括慢性结石性胆囊炎、股骨颈骨折、慢性硬模下血肿等3个病种,对实施临床路径前后抗菌药物应用进行统计分析。结果:外科Ⅰ类切口手术预防性抗菌药物使用率达到100%,都在术前0.5~2 h内进行预防性给药,手术时间在3 h内,术中都无追加抗菌药物。实施临床路径的病例,抗菌药物平均术后停药时间有所缩短,第1、2代头孢菌素类抗菌药物使用比例上升 ...
林嘉民, 黄南春
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Multi‐Scale Rational Design and Synergistic Strategies of Nanozymes for Targeting Drug‐Resistant Pathogens

open access: yesRare Metals, Volume 45, Issue 1, January 2026.
ABSTRACT The escalating issue of drug‐resistant pathogens, largely driven by the overuse of conventional antibiotics, has become a significant global health threat. Developing alternative therapeutic strategies and fabricating natural biological enzyme materials that mimic the high efficiency, selectivity, and mild‐operating conditions of natural ...
Shuai He   +11 more
wiley   +1 more source

Effect of antibiotic standardized management on prophylactic application of antimicrobial agents in type Ⅰ and Ⅱ incision [PDF]

open access: yes, 2015
目的探讨抗菌药物规范化管理对Ⅰ、Ⅱ类切口中抗菌药物预防应用情况的影响。方法选取厦门大学附属第一医院实施《抗菌药物临床应用管理办法》和《2013年全国抗菌药物临床应用专项整治活动方案》前临床外科有效手术病例250份和实施后临床外科有效手术病例200份,病例中Ⅰ类切口手术选取疝修补手术和甲状腺手术,Ⅱ类切口手术选取剖宫产手术,收集患者手术以及抗菌药物用药等基本情况,统计比较抗菌药物规范化管理和整顿前后患者术前抗菌药物使用率、手术期间抗菌药物给药时间选择、术后应用抗菌药物时间变化以及联合用药情况 ...
张秀梅   +3 more
core  

To Ban or Not to Ban: The UK's Hamlet Moment With Farm Antibiotics

open access: yesPolitics &Policy, Volume 53, Issue 6, December 2025.
ABSTRACT This article applies the Multiple Streams Framework (MSF) to examine post‐Brexit antimicrobial resistance (AMR) governance in UK agriculture, focusing on the contested regulation of prophylactic antibiotic use in farm animals. The study reveals how Brexit created a structural policy window, yet political and ideological dynamics rendered it ...
George Asiamah
wiley   +1 more source

抗菌药物专项整治活动对规范髋关节置换术抗菌药物预防使用的回顾性调查 [PDF]

open access: yes, 2018
目的评价抗菌药物专项整治活动对我院髋关节置换术围手术期抗菌药物的合理、规范化使用的促进作用。方法从围手术期预防性使用抗菌药物的使用率、品种选择、剂量、使用时机、疗程等方面对2010年8月~2014年7月于我院行髋关节置换的373份病例进行回顾性分析。结果经过抗菌药物专项整治活动,我院髋关节置换术围手术期抗菌药物预防使用率没有变化,但品种选择、给药时机、疗程日趋合理,术后住院时间及抗菌药费也明显下降 ...
卢志品, 曹伟
core  

抗菌药物对Hp感染胃溃疡患者血清胃蛋白酶原水平的影响 [PDF]

open access: yes, 2017
目的 探讨抗菌药物对幽门螺杆菌(Hp)感染胃溃疡患者血清中胃蛋白酶原水平的影响及治疗效果。方法选取厦门大学附属第一医院2015年10月—2016年9月收治并确诊Hp阳性胃溃疡患者86例,随机分为对照组(奥美拉唑治疗)和观察组(奥美拉唑和阿莫西林联合治疗),每组43例,比较两组治疗前后的血清胃蛋白酶原Ⅰ(PGⅠ)、PGⅡ水平,并观察两组的治疗效果。结果 两组治疗前的血清PGⅠ、PGⅡ水平比较,差异无统计学意义(P>0.05);治疗后两组患者的血清PGⅠ、PGⅡ水平明显下降,其中观察组PGⅠ ...
刘伟民   +4 more
core   +1 more source

An open‐label pilot study on an adsorbent mousse containing adelmidrol in client‐owned cats with feline atopic skin syndrome and associated seborrhoea

open access: yesVeterinary Dermatology, Volume 36, Issue 5, Page 638-646, October 2025.
Background – Besides pruritus and skin lesions, cats with feline atopic skin syndrome (FASS) may have seborrhoea. Hypothesis/Objectives – The aim of this pilot study was to investigate whether an adsorbent mousse containing tapioca starch, adelmidrol and a nonpharmacological antimicrobial complex could decrease FASS‐associated seborrhoea in cats ...
Chiara Noli   +4 more
wiley   +1 more source

LMP-027 Anti-Clostridium difficile activity, drug combination synergetic/additive effect, and tolerant mutant screening and characterization [PDF]

open access: yes, 2017
抗菌药物是对抗细菌感染的有力武器,自第一种抗生素青霉素被发现并应用于临床以来,人类已经开发出多种抗菌药物,然而由于抗菌药物的不合理使用,细菌耐药问题日益严峻,多重耐药菌不断出现,对人类健康构成严重威胁。这需要研发新型抗菌药物用于治疗多耐药细菌引起的感染;然而传统抗菌药物开发耗时长、成本高、风险大,医药公司对此并不热衷,新型抗菌药物上市越来越少。老药新用是抗菌药物开发的新思路,这些药物已经用于临床或正在进行临床试验,安全性评价资料齐全,这大大减少药物开发的成本和风险。过去几十年间 ...
刘俊坚
core  

Use of saline‐soaked bacterial culture swabs increases bacterial recovery in dogs with superficial bacterial folliculitis

open access: yesVeterinary Dermatology, Volume 36, Issue 5, Page 621-629, October 2025.
Background – Canine superficial bacterial folliculitis (SBF) is a common recurrent condition with a growing requirement for culture and susceptibility as a consequence of increased antimicrobial resistance and antimicrobial stewardship. Different opinions persist about the ideal technique for culture sample acquisition, which varies with lesion ...
Jason B. Pieper   +3 more
wiley   +1 more source

116例髋关节置换手术患者围手术期预防性应用抗菌药物分析 [PDF]

open access: yes, 2009
目的:了解我院髋关节置换手术患者围手术期抗菌药物的使用情况。方法:对我院2007年1月~2008年12月出院的116例髋关节置换手术患者围手术期抗菌药物的种类、给药频度、联用情况、用药时间等情况进行统计分析。结果:全部髋关节置换手术患者均应用抗菌药物。药物种类以头孢菌素类为主。不合理用药主要表现在预防用药选择起点高、无指征换药、手术过程中应用抗菌药物不规范、术后用药时间偏长等方面。结论:有必要加强我院外科手术预防性使用抗菌药物的管理 ...
李中海, 林嘉民, 王晓贤
core  

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