Effect of montelukast on leukotriene B4 metabolism in asthma [PDF]
, 2023 Objective·To observe the effect of montelukast on the expressions of key genes in LTB4 (leukotriene B4) metabolic pathway in treating asthma and investigate the candidate intervene targets of asthma.Methods·The acute, subacute, and chronic asthmatic ...
FU Hongling +6 more
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Ghrelin对脓毒症大鼠肺泡巨噬细胞炎症信号通路Akt、NF-κB和iNOS的影响 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2018 ： 【目的】观察生长激素释放肽（ghrelin）对脓毒症大鼠肺泡巨噬细胞（AM）炎症信号通路蛋白激酶 B （Akt）、核因子-κB（NF-κB）及诱导型一氧化氮合成酶（iNOS）的影响。【方法】24只SD雄性大鼠随机分为假手术 （Sham）组、脓毒症（CLP）组、ghrelin干预（CLP+ghrelin）组与ghrelin对照（Sham+ghrelin）组。盲肠结扎穿孔（CLP）构建 大鼠脓毒症模型，分别于术后3 h与5 h腹腔注射20 nmol/kg ghrelin进行干预 ...
郑海崇 +3 more
doaj +2 more sources
Fulminant psittacosis complicated with multiple organ dysfunction syndrome: a case report [PDF]
, 2023 The cases of fulminant psittacosis complicated with multiple organ dysfunction syndrome （MODS） have been rarely reported in China. In this article， clinical manifestations and treatment of a patient with fulminant psittacosis complicated with MODS were ...
Qian Xueqin, Wang Yi, Zhang Huitao, Shen Dezhi, Huang Kaizhuang, Zhu Yaoli
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Zhongshan Daxue xuebao. Yixue kexue ban, 2017 【目的】探讨呼吸道菌群失调对小鼠过敏性呼吸道疾病发病的影响。【方法】C57BL/6雌性小鼠给予万古霉素雾化吸入10 d后处死，应用16S rRNA高通量测序技术分析支气管肺泡灌洗液（BALF）菌群组成，探索建立小鼠呼吸道菌群失调模型的方法。建模成功后，应用相同的方法建立小鼠呼吸道菌群失调模型，在此基础上，通过腹腔注射致敏及雾化吸入卵清蛋白（OVA）激发，诱导小鼠过敏性呼吸道炎症反应，计数擦鼻频率，检测BALF中细胞总数及嗜酸性粒细胞百分比，肺组织病理分析炎症反应及杯状细胞增生情况 ...
王学坤 +4 more
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Latest Research Development in Histone Acetylation in the Pathogenesis of Asthma [PDF]
, 2022 Asthma is primarily marked by airway hyperresponsiveness, inflammation, and remodeling. Histone acetylation is one of the most common epigenetic modifications that regulates histone acetyltransferase and histone deacetylase, and imbalanced regulation may
CHEN Shaopeng, ZENG Minjuan, LAI Tianwen
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Novel Developments in the Relationship of Gut Microbiota and Immune Regulation with Childhood Asthma [PDF]
, 2022 Bronchial asthma, commonly known as asthma, is a frequently seen chronic respiratory disease that seriously threatens human health. More than 300 million people have had asthma worldwide, and most of them are children. Epidemiological investigations have
CUI Tianyi, LIU Jiarui, LYU Bin, GAO Xiumei, ZHAO Xin
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New insights in small airway dysfunction of childhood asthma [PDF]
, 2023 Small airway dysfunction (SAD) widely exists in different stages of childhood asthma, which is based on airway inflammation, airway remodeling and airway hyperresponsiveness. Among them, airway inflammation is the main pathological feature of SAD. It has
DONG Xiaoyan, ZHU Siyu
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Macrophage differential genes and their functions in silicosis based on single cell RNA sequencing and spatial transcriptome sequencing [PDF]
, 2022 BackgroundThe rise of single cell RNA sequencing (scRNA-seq) and spatial transcriptome sequencing technologies has allowed for intensive study of lung diseases, but both have been poorly studied in silicosis.
Jie CHAO, Wei ZHANG, Xinbei ZHOU
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Effect of Integrated Chinese and Western Medicine Treatment on Immune Factors in a Rat Model with Phlegm-heat Syndrome in Acute Exacerbation-stable Stage of Chronic Obstructive Pulmonary Disease [PDF]
, 2022 BackgroundSecretory immunoglobulin A (sIgA) deficiency and immune imbalance caused by T lymphocyte aggregation in lung tissue are associated with the development of chronic obstructive pulmonary disease (COPD) .
LI Xiaojun, LI Ya, BIAN Qingqing, XUAN Yinshuang, SHEN Tingting, LI Suyun
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Significance of changes in levels of neutrophil extracellular traps during development of silicosis in mice [PDF]
BackgroundSilicosis is an occupational disease mainly characterized by pulmonary progressive fibrosis induced by the accumulation of free silica (SiO2) in the lungs due to long-term exposure to SiO2 dust.
Hailan HE +7 more
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