Results 31 to 40 of about 538 (131)
Diagnotic Value of the Combined Determination of Telomerase Activity in Induced Sputum, Pleural Effusion and Fiberobronchoscopic Biopsy Samples in Lung Cancer [PDF]
, 2010 Background and objective It has been proven that telomerase activation correlates with the carcinogenesis, aggressiveness and turnover of lung cancer.
Cheng ZHAO +4 more
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表皮生长因子受体抑制剂对外源锌离子致大鼠急性呼吸道炎症的影响 [PDF]
, 2011 目的:探讨表皮生长因子受体(EGFR)抑制剂对外源锌离子致大鼠呼吸道急性炎症的影响。方法:将100μmol/L硫酸锌溶液经气管灌注大鼠肺部复制动物炎症模型,于灌注后4h、8h和24h处死大鼠,以PBS为对照,分别测定支气管肺泡灌洗液(BALF)中白细胞计数、总蛋白、白细胞介素8(IL-8)以及乳酸脱氢酶(LDH)的含量,以选择炎症最明显的时间点。进一步用二甲基亚砜(DMSO)和EGFR抑制剂PD153035预灌注大鼠,观察其对硫酸锌溶液所致呼吸道炎症的影响。结果:不同灌注液作用后大鼠白细胞计数(F=12.
关文池 +7 more
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Clinical analysis of 103 cases of invasive pulmonary fungal infection [PDF]
目的 分析侵袭性肺部真菌感染（IPFI）的临床特点，探讨防治对策。方法 对103例IPFI的临床资料进行回顾性分析。结果 IPFI以COPD、支气管肺癌多见，滥用抗生素等是主要危险因素；念珠菌属占57.3%，其次为曲霉菌属占32.0%；病死率为20.4%。结论 IPFI是在多种诱发因素下继发的肺部感染，原发性IPFI少见；其病死率高，重视易患因素的控制、尽早诊断，综合治疗可降低死亡率。Objective: To analyze the clinical features of invasive ...
Zeng, Zhi-ping, Zhang, Zu-ping
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儿童下气道菌群多样性及其对支气管哮喘辅助性T细胞分化机制影响研究进展 [PDF]
, 2018 哮喘是由多种细胞(如嗜酸性粒细胞、肥大细胞、T淋巴细胞、中性粒细胞、气道上皮细胞等)和细胞组分参与的以慢性气道炎症和气道高反应性为特征的一种异质性疾病[1]。近年来哮喘发病率逐年攀升,据全球哮喘防治创议(GINA)委员会调查显示,全球约有3亿人受到哮喘困扰[2],世界卫生组织(WHO)预计至2025年全世界哮喘患者将会增至4亿人。研究发现,哮喘患者气道菌群在丰度及多样性等方面与正常人存在显著差异[3 ...
侯凌云, 吴谨准, 葛丹丹
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, 2004 目的 观察太子健 煎剂对反复诱喘的哮喘豚鼠血和气道内嗜酸性粒细胞 (EOS)浸润的影响 ,及血中嗜酸性粒细胞阳离子蛋白 (ECP)含量的影响。方法 将豚鼠随机分为正常组、模型组、地塞米松组、太子健 高剂量和低剂量组 5组 ,后 4组分别用卵蛋白致敏 15 d后 ,再用卵蛋白反复诱喘 ,正常组用生理盐水代替 ,同时 ,正常组和模型组灌服生理盐水 ,其余 3组分别灌服地塞米松、太子健 高剂量和低剂量 ,予以治疗 ,连续 15 d。结果 太子健 煎剂可减少血及气道内 EOS浸润并降低 EOS的活性 ...
俞景茂, 周大兴, 赵育芳
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Involvement of let-7c in alveolar macrophage M2 polarization in coal mine dust-induced epithelial-mesenchymal transition in rat lung tissue [PDF]
BackgroundCoal workers' pneumoconiosis (CWP) is a serious occupational lung disease and one of the prescript occupational diseases in China. Epithelial-mesenchymal transition (EMT) is involved in the diffuse fibrosis of lung tissue of pneumoconiosis ...
Huifang ZHANG +5 more
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Effects of acute ozone exposure on pulmonary function and inflammation in mice [PDF]
Objective To investigate the effects of acute ozone exposure at different concentrations on pulmonary function and inflammation in mice. Methods Sixty-three male C57BL/6 mice were randomly divided into 9 groups and exposed daily to filtered air or ozone (
Hao CHEN +5 more
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Legionella pneumonia is mainly in community-acquired and nosocomial pneumonias caused by the L. pneumophila. The paper reported a case of Legionella pneumonia caused by Legionella pneumophila Sg1 in a man with malignant melanoma.
Hu, Chao-hui, Qiu, Yu-rong, Zhu, Qing-yi
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Effect of Qufeng Xuanbi Formula on experimental asthma guinea pigs' airway inflammation and Th1/Th2 cytokines [PDF]
目的 观察祛风宣痹方对哮喘豚鼠气道炎症和Th1/Th2细胞因子的影响，探讨其作用机制。方法 用卵蛋白和雾化吸入致敏法，复制豚鼠哮喘模型；取肺泡灌洗液进行嗜酸性粒细胞(Eos)计数；肺组织切片HE染色形态学观察；ELASA方法检测BALF中IFN-γ和IL-4的含量。结果 模型组较正常组肺泡灌洗液(BALF)中气道Eos炎症细胞表达异常，组织形态学病变明显，IFN-γ含量显著下降，IL-4的含量明显升高；地塞迷松米组、中药高剂量组、中药低剂量组较模型组均有显著性差异，BALF中Eos的数量明显降低 ...
Shi, Suo-fang, Zhou, Kui-long
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Emerging treatment strategies for pulmonary fibrosis in precision medicine [PDF]
Pulmonary fibrosis （PF） is a chronic progressive lung disease that poses a serious health risk. It is mainly characterized by abnormal fibrosis and scarring of lung tissues， resulting in the gradual replacement of alveoli with fibrous tissues and ...
XIA Dong, YANG Huiling
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