Results 31 to 40 of about 2,304 (158)

Effect of Ba Zhu Decoction(BZD) on the related mechanisms of Aβ formation in 5xFAD transgenic mice [PDF]

open access: yes, 2016
目的:巴茱合剂是本人硕士导师治疗阿尔兹海默病(AD)的经验方,前期临床研究证明,巴茱合剂能有效缓解AD患者认知功能障碍,但对巴茱合剂的作用机制尚未深入研究。本文旨在通过AD转基因动物再次验证巴茱合剂的治疗效果,并进一步探索巴茱合剂治疗AD的相关分子生物学机制。 方法:(1)选取新型APP/PS1转基因小鼠(5xFAD小鼠)作为实验对象。将3月龄5xFAD小鼠随机分为模型组(5xFAD-Control)、巴茱合剂低剂量组(5xFAD-BZD-L)、中剂量组(5xFAD-BZD-M)、高剂量组(5xFAD ...
彭阿香
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Predicting Spatial Distributions of Mammalian Predation on Translocated Wild Turkeys in Agriculturally Dominated Landscapes 在以农业为主的景观中哺乳动物对易地放归的野生火鸡捕食的空间分布预测

open access: yesWildlife Letters, Volume 3, Issue 3, Page 91-98, September 2025.
The edge densities of cropland, developed land, and water bodies (panel a) predict the spatial probability of mammalian predation on wild turkeys (panel b) using Mahalanobis distance factor analysis in Quitman County, Mississippi, United States. The three habitat fragmentation variables are represented by three arrows, respectively.
Guiming Wang   +2 more
wiley   +1 more source

高频超声对老年高血压水平与颈动脉斑块关系的研究

open access: yesZhongguo shiyan zhenduanxue, 2015
彩色多普勒高频颈动脉超声检查,对临床预测颈动脉狭窄程度、评估斑块成分提供了有效的手段[1]。斑块内有无出血发生、有无溃疡形成及斑块的增长速度是决定斑块稳定性的重要因素。高血压水平与心脑血管事件的风险评估,易损斑块的发生率的预测是预防高血压的关键[2]。本研究采用高频超声评价对老年高血压水平与颈动脉斑块关系,及时发现颈动脉易损斑块 ...
邱文风, 聂颖, 李素英, 景文宝
doaj  

急性颈内动脉系统脑梗死患者颈内动脉角与动脉粥样硬化斑块形态关系的研究 Relationship between Internal Carotid Artery Angle and Plaque Morphology in Patients with Acute Anterior Circulation Infarction

open access: yesZhongguo cuzhong zazhi, 2019
【摘要】 目的 利用颈动脉高分辨率磁共振成像(high resolution MRI,HR-MRI)技术分析急性脑梗死患者颈内动脉角(internal carotid artery angle,ICAA)与动脉粥样硬化斑块形态学特点,探讨ICAA与动脉粥样硬化斑块形态的关系。 方法 入组2011年11月-2012年6月的急性颈内动脉系统脑梗死患者,行颈动脉HR-MRI检查,获得每例患者左右侧ICAA及动脉粥样硬化斑块形态资料。根据ICAA大小的中位数将颈动脉分为ICAA≥35°组和ICAA<35°组,
王琳,王晶,申园,龚浠平,刘艳芳
doaj   +1 more source

Simvastatin inhibit glucose uptake through insulin receptor dependent IRS1/PI3K/Akt pathway in mouse myotubes [PDF]

open access: yes, 2015
他汀类药物是羟甲基戊二酸单酰辅酶A(3-hydroxy-3-methylglutaryl-CoA,HMG-CoA)还原酶抑制剂,可竞争性抑制内源性胆固醇的合成。大量研究表明长期服用他汀类药物可增加新发糖尿病的发病风险,但具体机制尚不清楚。 本实验使用辛伐他汀及胆固醇代谢中间产物甲羟戊酸内酯干预小鼠骨骼肌细胞(由小鼠成肌细胞C2C12细胞分化而来),采用免疫印迹法(immunoblotting)、流式细胞术、细胞毒性试验和葡萄糖消耗试验,研究辛伐他汀和甲羟戊酸内酯对骨骼肌细胞葡萄糖代谢的影响及其作用机制 ...
梁晓静
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Biosphere reserves in the megadiverse Cape Floristic Region are effective in conserving arthropod diversity 开普植物区的生物圈保护区有效保护了节肢动物多样性

open access: yesIntegrative Conservation, Volume 3, Issue 4, Page 312-329, December 2024.
Biosphere reserves aim to protect global biodiversity alongside social and economic development. In the Cape Floristic Region, biosphere reserves are an effective conservation approach to protect arthropods against habitat transformation in this biodiverse region.
Michael J. Samways   +3 more
wiley   +1 more source

Comparasion study on the effects of mangrove wetland sediments on the sequestration of typical sulfonamides from the estuarine water [PDF]

open access: yes, 2015
作为陆地污染物进入海洋的屏障,红树林已然成为众多典型污染物汇聚的场所之一。近年来,海产养殖业的大肆兴起更是加重了抗生素在红树林区的直接污染。锁定态是控制土壤抗生素归宿的主要因素,具有环境存在时间长,危害大等特点,可通过再释放重回到环境中,对环境造成长期危害。对典型磺胺类在红树林群落沉积物中锁定能力的研究对于探索抗生素在红树林区的环境行为和红树林湿地抗生素污染控制及修复功能评估具有现实意义。本文选取了12种水产、禽畜及人用较为频繁的典型磺胺类药物,分别为磺胺甲噻二唑(sulfamethizole,SMT)、
张宇
core  

Multi‐Scale Spatial Effects Determine Nest Success in Small Urban Forest Patches 多尺度空间效应决定了城市小型森林斑块中的筑巢成功率

open access: yesWildlife Letters, Volume 2, Issue 4, Page 192-203, December 2024.
Knowledge of the reproductive success of organisms in urban habitat fragments is needed to conserve biodiversity in our urbanizing world. We found that differences in nest success among birds in urban forest patches is explained by factors on three distinct spatial scales even across a limited urban development gradient.
Ohad J. Paris, Colin E. Studds
wiley   +1 more source

速度向量成像技术评价颈动脉硬化斑块内部应变

open access: yesZhongguo shiyan zhenduanxue, 2011
颈动脉粥样硬化斑块与缺血性脑卒中密切相关,而斑块的不稳定性是其危险性的最重要因素。因此对于颈动脉粥样硬化斑块稳定性的研究尤为重要。本研究应用速度向量成像(VVI)技术初步分析颈动脉粥样硬化斑块受力后的形变特点,探讨该项技术在评价斑块力学状态方面的应用价值 ...
冯海艳   +5 more
doaj  

The Role of Steroid Receptor Coactivator 3 in Atherosclerosis [PDF]

open access: yes, 2016
目的:动脉粥样硬化是动脉壁对炎症的损伤性反应,是多种细胞及因子相互作用的结果,但目前的发病机制仍不清楚。血管内皮损伤、脂质代谢紊乱、炎症反应在其发生发展中都扮演重要角色。类固醇受体辅激活因子3不仅能抑制甘油三酯向肝外转运,而且在炎症应答中扮演着重要角色,目前SRC-3在动脉粥样硬化中的研究还未曾报道,我们的研究旨在揭开SRC-3对动脉粥样硬化的影响的具体机制。方法:确定动脉粥样斑块的血管SRC-3表达量增高后,我们获取APOE-/-、SRC-3-/-敲除小鼠和APOE-/-、SRC-3+/+小鼠 ...
苏强
core  

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