Research progress of tumor-associated macrophages in immune microenvironment and targeted therapy of osteosarcoma [PDF]
, 2023 Osteosarcoma (OS) is a common primary malignant bone tumor in children and adolescents. The high recurrence and metastasis rate have become a common clinical problem to be solved, but there is no effective treatment.
CHEN Junjun +5 more
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Recent advances and prospect in immune microenvironment and its mechanisms of function in head and neck squamous cell carcinoma [PDF]
, 2023 Head and neck cancer (HNC) remains a significant cause of morbidity and mortality. The most prevalent pathology among HNC is head and neck squamous cell carcinoma (HNSCC).
ZHANG Shaoqiu, YAN Li, LI Ruichen, ZHAO Yang, WANG Xiaoshen, YANG Xuguang, ZHU Yi
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Enhancement of Innate Immune Function in Mice by Bifidobacterium bifidum FL-228.1 [PDF]
, 2023 In this study, eight potential functional strains were selected to interfered with RAW264.7 murine macrophages and human peripheral blood mononuclear cells (PBMCs).
Huaxi YI +8 more
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携带AFP的rAAV感染树突状细胞对肝癌细胞杀伤作用的实验研究
Zhongguo shiyan zhenduanxue, 2020 目的探讨携带甲胎蛋白(AFP)的重组腺相关病毒(rAAV)感染树突状细胞(DCs)对肝癌细胞株SMMC-7721的体外杀伤作用,为肝癌非手术治疗提供方法。方法首先确定AFP基因序列并合成AFP基因,将其转染至重组腺相关病毒rAAV,之后将转染AFP的rAAV感染树突状细胞,并将感染rAAV的DC与SMMC-7721共同培养,同时设未感染rAAV的DC作为对照组,用MTT法检测rAAV-DC及DC对SMMC-7721的杀伤活性。结果感染rAAV的DC对SMMC-7721的杀伤活性为89.00 ...
王斌 +5 more
doaj
Research progress of the role of non-canonical Wnt signaling pathway in ovarian cancer and its potential therapeutic implications [PDF]
, 2023 Ovarian cancer is a malignant tumor of the female reproductive system with the highest mortality, and involves the aberrant regulation of multiple molecular signaling pathways.
TENG Yincheng, ZHOU Wanzhen
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平糖方对糖尿病大鼠血清SVCAM-1、CRP、TNF-α及PAI-1水平的影响 [PDF]
, 2006 目的:观察平糖方对糖尿病大鼠血清SVCAM-1、CRP、TNF-α及PAI-1水平的影响。方法:取Wistar大鼠喂养高热量饲料,2 m后,一次性腹腔注射链脲佐菌素(STZ)25 mg/kg,造成类似人类2型糖尿病模型。将糖尿病大鼠随机分为模型组、氨基胍组及平糖方大、中、小治疗组,连续干预16 w。采用ELISA法检测大鼠血糖(BG)、血脂、SVCAM-1、CRP、TNF-α及PAI-1水平。结果:平糖方大、中剂量不仅可显著降低糖尿病大鼠BG、TG及LDL-c水平 ...
李学军, 杨叔禹, 陈福
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Novel Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia [PDF]
, 2016 缺血乏氧是肿瘤微环境的重要特征之一，肿瘤的缺血乏氧不仅促进了肿瘤细胞的侵袭转移，同时还增强肿瘤对化疗药物的耐药性。肿瘤相关巨噬细胞（Tumor-associatedmacrophages，TAMs）浸润在肿瘤微环境之中，通常在肿瘤缺血乏氧区域富集。肿瘤相关巨噬细胞作为肿瘤微环境的重要功能细胞，其在肿瘤细胞的增殖、侵袭、转移、化疗耐药等肿瘤进展的各个阶段均发挥着重要作用。鉴于此，我们提出一种新型的肿瘤治疗策略，以期改变肿瘤微环境的同时，增强实体瘤对化学治疗的疗效 ...
宋曼莉
core
Optimization study of CAR-T cell expansion targeting CD99 [PDF]
Background and purpose: Chimeric antigen receptor T (CAR-T) cell therapy has shown remarkable efficacy in treating hematological and lymphatic system tumors, but its effectiveness in solid tumors is relatively poor, which is partly attributed to target ...
WANG Yixuan, YU Miao, ZHAO Jiaxuan, ZHAO Fenfang, ZENG Yi, WANG Youyong, ZHU Haichuan, ZHANG Tongcun, SHI Jiangzhou
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Influence of the JAK-STAT Signal Pathway on the Antitumor Activity of CIK Cell on Hepatoma Cell [PDF]
, 2010 细胞因子诱导的杀伤细胞（Cytokine-inducedKillerCell，CIK）是人外周血单个核细胞(peripheralbloodmononuclearcells，PBMCs)经细胞因子诱导成的具有肿瘤杀伤能力的一群异质细胞。JAK-STAT信号通路与细胞的生长、增殖、分化和凋亡关系十分密切。研究显示，JAK-STAT信号通路参与了机体中的许多免疫调控活动。IFN-γ和IL-2是激活JAK-STAT信号通路的重要配体，也是刺激和活化CIK细胞杀伤肿瘤细胞的重要细胞因子。本论文的研究目的 ...
马飞剑
core
Research Progress on Immunomodulatory Activity of Polysaccharides from Blue Foods [PDF]
, 2023 With the current over-exploitation of terrestrial resources, multi-dimensional in-depth utilization of aquatic resources has attracted widespread attention.
GU Fudie, ZHOU Yu, CHEN Huiying, LIU Wenmei, ZOU Zehua, LIU Guangming, LIU Qingmei
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