研究B16黑色素瘤细胞在自然杀伤(NK)细胞环境中获得NK耐受力的现象,并建立了暂时耐受NK的B16亚群。将小鼠分别用PolyI:C和anti-asialoGM1,处理以活化和灭活NK细胞,制备其脾淋巴细胞悬液。当B16细胞反复多次与高NK活性的脾淋巴细胞共同孵育后,能在体内或体外抵抗NK细胞的杀伤。这说明经受NK攻击后的肿瘤细胞能从NK的攻击中获取对NK的耐受力,这一现象也许是肿瘤在机体内得以生存、发展并浸润转移的重要因素之一。
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[A mechanistic study of radiotherapy on intratumoral NK cell infiltration augmentation by regulating the EZH2/CXCL10 pathway in hepatocellular carcinoma cells]. [PDF]
Zhao XF +6 more
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【目的】 探讨脾细胞输注致敏对异基因供者骨髓细胞损伤的作用机制65377;【方法】 应用异基因脾细胞输注的BALB/c小鼠作为致敏模型,未致敏(正常)BALB/c小鼠作为对照,异基因供者骨髓细胞来源于C57BL/6小鼠65377;通过补体依赖细胞毒性反应(CDC)65380;细胞毒性免疫细胞杀伤作用65380;抗体依赖细胞介导的细胞毒性作用(ADCC)65380;粒-单核细胞集落培养(CFU-GM)等实验研究致敏血清及致敏免疫细胞对异基因骨髓细胞的影响65377;【结果】 与补体孵育30 min或1 ...
doaj
[Research progress on toxic shock syndrome due to group A <i>Streptococcus</i> infection in children]. [PDF]
Wang HY, Zhou W, Huang LS.
europepmc +1 more source
[Clinical Progress and Prospects of mRNA Tumor Drugs]. [PDF]
Chen J +5 more
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[Mechanistic research progress on radiotherapy resistance of cancer stem cells]. [PDF]
Luo Z, Yu M, Li J, Zhang S, Shen T.
europepmc +1 more source
[Research Advances on the Immune Evasion Mechanisms of Disseminated Tumor Cells and Their Roles in Cancer Metastasis]. [PDF]
Que Z, Luo B, Tian J.
europepmc +1 more source
[Mechanisms and clinical research progress of mesenchymal stromal cell therapy for steroid-refractory acute graft-versus-host disease]. [PDF]
Wang N, Xu ZL, Liu DH.
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[Cytotoxic effects of the novel photosensitizer PEG<b>-</b>MTPABZ<b>-</b>PyC<b>-</b>mediated photodynamic therapy on gastric cancer cells]. [PDF]
Chen L +11 more
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[Application and research progress of metal-organic framework materials in skin repair]. [PDF]
Ma S, Wu W, Liu H, Liu M, Xing F.
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