Blastic plasmacytoid dendritic cell neoplasm complicated with acute myeloid leukemia: a case report [PDF]
, 2023 Blastic plasmacytoid dendritic cell neoplasm （BPDCN） complicated with acute myeloid leukemia （AML） is a rare disease. In this article， we reported the diagnosis and treatment of one patient of BPDCN complicated with AML who presented with fever as the ...
Kong Lihua, Qin Lili, Feng Anhua, Liu Zhenzhen, Tang Na, Zang Jikang, Wang Haiying
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浆细胞样树突状细胞在宿主抵御隐球菌肺部感染中的作用及机制研究进展 [PDF]
, 2018 肺隐球菌病是由隐球菌感染引起的常见真菌病,由于症状的非特异性,临床上诊断较为困难。作为条件致病性真菌感染,肺隐球菌病的结局主要与宿主免疫力有关。目前肺隐球菌病免疫学发病机制研究主要局限在T细胞和巨噬细胞。近年研究表明,作为树突状细胞亚群之一的浆细胞样树突细胞,由于其激活后可以产生大量的I型干扰素并活化相关的T细胞,所以在机体抵抗病毒和细菌免疫中发挥着重要的作用。但是浆细胞样树突细胞在真菌病,尤其是在隐球菌病的发生发展中发挥的作用尚不明确。本文将介绍肺隐球菌病的临床表现 ...
刘晓刚 +5 more
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Correlation of LC3 and the recruitment of dendritic cell and the formation of TLS in colorectal cancer and its clinical significance [PDF]
, 2023 Background and purpose: It has been recognized as a complex problem in tumor therapy to deal with the tumor immune escape, and over-activated autophagy can cause the increase of tumor surface antigen, which participates in anti-tumor immunity.
WU Han, XU Lei, WANG Miaomiao, ZHANG Ruizhe, XU Xiaoyang, GUO Ningjie, WU Shuhua
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Zhejiang Daxue xuebao. Lixue ban, 2003 用ICAM-1(Intercellular adhesion molecule-1)和S-100 免疫组织化学技术,Ishigami 分级记数和统计学分析方法,研究结肠癌淋巴转移时细胞间粘附分子-1在淋巴管内皮细胞中的表达和树突状细胞(Dendritic cells,DCs)的分布.正常结肠组织淋巴管内皮细胞ICAM-1表达阴性,癌组织淋巴管内皮细胞ICAM-1表达呈阳性.随着癌组织浸润深度的增加,ICAM-1阳性淋巴管数目逐渐增多 ...
SUZhi-hong(宿志弘) +2 more
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Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Nanozymes have attracted considerable attention in cancer therapy due to their adjustable enzyme activity and high catalytic efficiency. However, they still face a major challenge from tumor metastasis. In this work, endogenous/exogenous dual‐responsive bimetallic hollow PdRu (termed HPdRu) nanozymes were prepared.
Nan‐Nan Zheng, Xin Hu, Jun‐Qing Hu
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The Th cell subsets analysis of syphilis patients and mechanism of Treponema pallidum infection [PDF]
, 2016 梅毒是由梅毒螺旋体引起的性传播疾病。梅毒螺旋体可侵入人体各个组织器官，引起各种临床表现。目前机体对梅毒螺旋体的免疫机制尚不清楚。本课题分别从体内和体外实验分析梅毒螺旋体引起的初始Th细胞分化，初步探讨梅毒螺旋体细胞免疫机制。我们分析32例梅毒患者外周血辅助性T细胞（Th）亚群含量变化；通过兔皮内接种模型，分析梅毒螺旋体感染后局部炎症反应中IFN-γ和IL-4mRNA的表达随时间变化情况。体内研究发现梅毒螺旋体感染后细胞免疫应答在人外周血和兔皮损中IFN-γ含量明显升高，Th1型细胞增多 ...
张巧
core
The effects of ubiquitination inhibitors Thalidomide and PYR-41 on cross-presentation of dendritic cells [PDF]
, 2016 树突状细胞(Dendriticcells，DCs)是机体最为重要的抗原提呈细胞(Antigenpresentingcell，APC)。DCs对抗原的交叉提呈是指外源性抗原被DCs摄取和加工后，与MHCI类分子结合形成CD8+特异性抗原肽-MHCI类分子复合物的过程，可使T细胞分化为CD8+特异性细胞毒T细胞(CytotoxicTlymphocyte，CTL)。甘露糖受体(Mannosereceptor，MR)是DCs表面重要的的模式识别受体(Patternrecognitionreceptor，PRR)，
游翔
core
pJAK2 polypeptide,an antagonist of suppressors of cytokine signaling-1,can enhance the antitumor effect of dendritic cells [PDF]
, 2013 目的:探讨细胞因子信号转导抑制因子-1(SuPPrESSOrS Of CyTOkInE SIgnAlIng1,SOCS1)拮抗物PJAk2多肽(氨基酸序列号为1001-1013)参与树突状细胞(dEndrITIC CEllS,dCS)的体外诱导培养后对dCS抗肿瘤作用的影响。方法:采集健康人外周血,离心获得单个核细胞,用重组人粒细胞巨噬细胞集落刺激因子(rECOMbInAnT HuMAn grAnulOCyTE-MACrOPHAgE COlOny STIMulATIng fACTOr,rHgM-CSf ...
丁园 +8 more
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Applying TALEN and CRISPR/Cas9 Technique to Knock out the PD1 Gene in Human Primary T Lymphocytes [PDF]
, 2016 过继性细胞免疫治疗(adoptivecellularimmunotherapy)是将患者自体免疫细胞在体外处理，然后筛选并大量扩增具有高度特异性的肿瘤杀伤性免疫效应细胞，再回输到患者体内杀灭肿瘤的一种治疗方法，过继性T细胞治疗是一种很有前景的癌症治疗方法。体内T细胞在进行免疫应答时，T细胞活化需要双重信号的协同作用，分别是抗原呈递信号和协同刺激信号。协同刺激分子通过为淋巴细胞提供正性或负性的调控信号参与机体的免疫调控。肿瘤细胞会利用体内免疫调节过程，表达或分泌的一些分子，对T细胞进行负向调控 ...
李剑
core
Reprogramming of global histone methylation controls the differentiation of monocytes into macrophages [PDF]
, 2016 单核-巨噬细胞系统由一类具有吞噬功能的免疫细胞组成，包括单核细胞、巨噬细胞及树突状细胞，是机体免疫系统重要的组成之一。来源于造血干细胞的单核细胞在趋化因子激活下，分化为巨噬细胞和树突状细胞，参与机体防卫。目前有关单核-巨噬细胞分化的细胞学过程已基本阐释，然而分化进程中关键分子及其调控网络仍需要深入阐明。此外，单核细胞如果过度增生，会导致正常造血功能衰竭。白血病的发生也与单核-巨噬细胞系统的异常发展有关。因此，深入探索和阐明单核/巨噬细胞形成过程中关键转录因子及其调控网络 ...
王慧敏
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