Results 21 to 30 of about 13,500 (118)

Lipid Nanoparticles Delivering ClpP‐mRNA Suppress Pyroptosis and Senescence in Intervertebral Disc Degeneration via mTOR/BNIP3‐Activated Mitophagy

open access: yesRare Metals, Volume 45, Issue 2, February 2026.
ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang   +7 more
wiley   +1 more source

Metadiscourse and Teacher Moves for Supporting Student Reasoning in Linguistics Classroom Interactions

open access: yesInternational Journal of Applied Linguistics, Volume 36, Issue 1, Page 522-539, February 2026.
ABSTRACT This paper examines the features of metadiscourse across different teacher moves in university linguistics classroom discourse and the teaching strategies reflected in its use. The results reveal that teachers employ diverse metadiscourse during classroom interactions to support student reasoning.
Jingjie Li, Wenjie Hu
wiley   +1 more source

The Relationships Between Lower‐ and Higher‐Level Cognitive Skills and Multimodal Reading Comprehension Among Fourth‐Grade Students in the Digital Age

open access: yesInternational Journal of Applied Linguistics, Volume 36, Issue 1, Page 509-521, February 2026.
ABSTRACT Multimodal reading skills are essential for 21st‐century students to interpret and navigate information across various modalities on the Internet and in multimedia environments. While previous studies have delved into the effects of lower‐ and higher‐level cognitive skills on traditional reading comprehension, which involves solely written ...
Yaping Liu, Choo Mui Cheong, Xinhua Zhu
wiley   +1 more source

染色体分析联合骨髓活检诊断无明显病态造血的早期骨髓增生异常综合征

open access: yesZhongguo shiyan zhenduanxue, 2009
目的评价染色体核型分析联合骨髓活检在诊断无明显病态造血的早期骨髓增生异常综合征(MDS)中的价值。方法回顾性分析9例有克隆性染色体异常的无病态造血改变的早期MDS的染色体核型和骨髓活检组织切片特征。结果9例MDS患者中,8例为轻度的异常核型,1例为复杂核型。4例有+8异常,2例有13、20号染色体异常,9、10、11、12、14号染色体受累各1例。骨髓切片CD61免疫组化示2例有微小巨核阳性,检出1例典型髓系幼稚前体细胞异常定位(ALIP),3例患者骨髓切片CD34 ...
谢守军, 王娜
doaj  

18q缺失综合征产前诊断方法

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2023
目的探讨18q缺失综合征的产前诊断方法,提高对无创产前筛查(NIPT)技术在18q缺失综合征产前诊断中应用价值的认识。方法本研究通过对孕妇进行血清学筛查、超声影像学检查、羊水核型分析及亲本外周血染色体核型分析等传统检查手段以及NIPT检查、染色体微阵列芯片检测(CMA)、流产组织基因组拷贝数变异测序(CNV-Seq)检测等分子生物学技术来诊断18q缺失综合征,并根据检查结果进行遗传咨询。结果该病例NIPT结果提示18号染色体24 Mb片段缺失,经过羊水核型分析及CMA检测证实 ...
马莉   +4 more
doaj  

Blockchain and Quantum Technologies for Securing the Global Nuclear Supply Chain: Synergies, Applications, Technical Challenges and Opportunities

open access: yesJournal of Critical Infrastructure Policy, Volume 7, Issue 1, Spring/Summer 2026.
ABSTRACT The infiltration of counterfeit, fraudulent, and suspect items into civil nuclear supply chains, notably within power generation and medical isotope production, poses severe safety and security threats. The ever‐increasing growth in nuclear installations (70 power plants are under construction and another 100 are in the planning stage) and the
Hafiz Ahmed
wiley   +1 more source

原发性胆汁性肝硬化所致肝癌患者自身抗体特征分析

open access: yesZhongguo shiyan zhenduanxue, 2014
目的探讨原发性胆汁性肝硬化(PBC)合并原发性肝癌(HCC)患者的自身抗体特征分析。方法回顾性分析2007-2012年于我院住院治疗PBC患者350例,对这些患者抗线粒体抗体(AMA)、抗线粒体抗体M2亚型(AMA-M2)、抗核抗体(ANA)、抗平滑肌抗体(SMA)、抗肝肾微粒体抗体(LKM)滴度及ANA的核型分析。结果350例PBC患者发展为肝癌为2.57%(9/350),其中女性患者2.38%(7/293),男性患者3.5%(2/57),9例患者中有7例可见AFP值升高,8例患者可见AMA、AMA ...
李卓敏   +6 more
doaj  

Achieving Crack‐Free Laser Powder Bed Fusion of AlxFeCoCrNi Alloys With B2‐Decorated Substructures via Low‐Al In Situ Alloying

open access: yesRare Metals, Volume 45, Issue 1, January 2026.
ABSTRACT The B2 phase is a critical strengthening constituent in AlxFeCoCrNi high‐entropy alloys (HEAs), and introducing such phases onto the nanoscale cellular substructures is an ideal pathway for strengthening alloys fabricated by laser powder bed fusion (L‐PBF).
Xiangjian Zhu   +5 more
wiley   +1 more source

运用HRM技术分析7个SNP位点与2型糖尿病相关性

open access: yesZhongguo shiyan zhenduanxue, 2012
目的采用高分辨熔解曲线(high-resolution melting,HRM)方法检测7个2型糖尿病(T2DM)患者相关易感单核苷酸多态性,并分析该多态性与2型糖尿病的相关性。方法选取202名T2DM患者和200名健康志愿者,提取外周血DNA,采用HRM技术分析其多态性,并用测序法证实。结果成功地检测T2DM患者相关易感单核苷酸多态性。HRM技术检测能准确区分各种基因型,其结果与测序法一致;研究还显示rs10811661和rs10923931位点在本研究人群中与T2DM无相关 ...
左玲, 左磊
doaj  

US Foreign Policy and the Gulf States: Changing Dynamics in a Multipolar World

open access: yesWorld Affairs, Volume 188, Issue 4, Winter 2025.
ABSTRACT This article focuses on US foreign policy toward the Gulf from Obama's Pivot to Asia to the initial period of the second Trump administration. It situates the role of the US within the broader context of the global energy transition and the Gulf states as geopolitical actors in a multipolar world order.
Steven Wright
wiley   +1 more source

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