Zhongshan Daxue xuebao. Yixue kexue ban, 2016 摘 要: 【目的】 探讨利福平对鱼藤酮诱导的BV2小胶质细胞氧化损伤中的核因子E2相关因子2(Nrf2)信号通路的影响?【方法】 利用鱼藤酮刺激的BV2小胶质细胞建立帕金森病氧化应激的模型,分别用不同浓度的利福平预处理BV2小胶质细胞,CCK-8法检测细胞存活率;分别用双氯荧光素(DCFH-DA)?罗丹明123染色后使用流式细胞仪检测活性氧(ROS)水平和线粒体膜电位(MMP);使用脂质氧化检测试剂盒测定细胞内脂质过氧化终产物丙二醛( MDA) 的含量?采用Western ...
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Zhongguo shiyan zhenduanxue目的 通过检测补锌对高脂饮食诱导的糖调节受损（IGR）大鼠肝脏病理变化、氧化和抗氧化、线粒体损伤及凋亡的影响，探讨补锌缓解IGR肝脏损伤的机制。方法 雄性Wistar大鼠80只，利用长程高脂饮食连续喂养20周建立IGR模型，并利用苏木素-伊红（HE）染色检测胰腺的病理损伤。32只IGR模型大鼠随机分成IGR模型组（IGR）、15 mg·kg-1·d-1补锌组(IGR+Zn15mg)、30 mg·kg-1·d-1补锌组(IGR+Zn30mg)和二甲双胍阳性药物组（IGR+Met）组，每组8只 ...
王琳, 方芳, 田宏远, 吕巍
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[Gandou Bushen decoction ameliorates ovarian injury in murine hepatolenticular degeneration via the AGE/RAGE/NF-κB signaling pathway]. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue BanJiang P, Wu L, Han H.
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[He<b>'</b>s Yangchao recipe ameliorates premature ovarian insuffi-ciency by regulating 8-oxoguanine DNA glycosylase 1 in mice]. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue BanHu R +7 more
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Trx2、GSH和GSH-PX与大鼠肝移植术后肾损伤修复的相关性研究
Zhongshan Daxue xuebao. Yixue kexue ban, 2013 【目的】 探讨线粒体型硫氧还蛋白(Trx2),谷胱甘肽(GSH)和谷胱甘肽过氧化物酶(GSH-PX)对肝移植术后急性肾损伤的保护作用。【方法】 建立大鼠肝移植模型,将雄性SD大鼠35只,随机均分为假手术组(n = 7)和移植后4 h组(n = 7),移植后8 h组(n = 7),移植后16 h组(n = 7)和移植后24 h组(n = 7)。假手术组只进行开腹和血管的分离,各移植组接受自体肝移植。观察大鼠自体肝移植后不同时期肾脏病理、活性氧水平、Trx2表达、乳酸脱氢酶(LDH)、谷胱甘肽(GSH ...
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[Exosomes from ectoderm mesenchymal stem cells inhibits lipopolysaccharide-induced microglial M1 polarization and promotes survival of H2O2-exposed PC12 cells by suppressing inflammatory response and oxidative stress]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoSun X +9 more
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[The role of polyunsaturated fatty acid lipid peroxidation in ferroptosis after intracerebral hemorrhage: a review of mecha-nisms and therapeutic implications]. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue BanGuo M, Zhao G, Cai Z, Zhang Z, Zhou J.
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[Gastrodin inhibits ferroptosis to alleviate hypoxic-ischemic brain damage in neonatal mice by activating GPX4/SLC7A11/FTH1 signaling]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoGuo T +8 more
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[Application and research progress of metal-organic framework materials in skin repair]. [PDF]
Sheng Wu Yi Xue Gong Cheng Xue Za ZhiMa S, Wu W, Liu H, Liu M, Xing F.
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[Dietary secoisolariciresinol diglucoside alleviates chronic kidney disease in offspring rats caused by maternal trans-fatty acid exposure by regulating the Bcl-2/Bax/caspase-3 signaling axis]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoMa S, Chen M, Wu T, Zhao W.
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