Results 21 to 30 of about 6,409 (145)
Antagonism tributyltin toxicity effect and its mechanism research of fucoxanthin, fucoxanthol andantioxidant peptides. [PDF]
, 2017 三丁基锡（Tributyltin，TBT）是一种影响广泛的持久性有机化合物。有关TBT对生物体的毒性作用、作用机理以及污染治理问题等方面已开展了深入的研究，但如何缓解TBT对机体的毒性作用，减少TBT等有机污染物对机体健康造成的危害还缺乏广泛而深入的研究。本研究以体外培养的HepG2细胞系和C57BL/6小鼠为模型，探讨海洋天然产物岩藻黄质（Fucoxanthin，Fx）、岩藻黄醇（Fucoxanthol，FxOH）和抗氧化肽（AntioxidantPeptides，AP ...
曾洁
core
Zhongguo shiyan zhenduanxue, 2021 细胞通过有氧代谢使生命活动得以进行和维持,有氧代谢过程中会产生活性氧(ROS)等多种自由基[1]。自由基对细胞来说是一把双刃剑,一方面,自由基是有氧代谢所必备的;另一方面,对机体存在毒性。许多实验已经表明,自由基反应能导致细胞退化、老化、裂解[2]。H2O2是一种ROS,在诱导细胞的损伤、死亡中起关键作用。它能损伤DNA、使酶失活、氧化激素、破坏细胞膜的完整性,甚至杀死细胞等,是多种疾病的起点[3]。
李波, 信瑞, 柳承鑫, 曲丹华
doaj
Role and Mechanism of 20-Hydroxyecdysone in Oxidative Damage of HepG2 Cells Induced by High Glucose [PDF]
Objective: To explore the protective effects of 20-Hydroxyecdysone (20-HE) on high glucose induced HepG2 cells and its related molecular mechanism. Methods: In this study, high glucose (50 mmol/L glucose) was used to establish the oxidative damage model ...
Hao LI +5 more
core +1 more source
Zhongguo shiyan zhenduanxue, 2013 目的本文设计并合成了一个具有高活性的抗坏血酸过氧化物模拟酶-次血红素六肽,并探讨了次血红素六肽对离体心肌线粒体氧化损伤的保护作用。方法以Vc/Fe3+/MT自由基诱导损伤体系建立了离体心肌线粒体氧化损伤模型,以膜脂质过氧化产物丙二醛（MDA）,线粒体膨胀度和细胞色素C氧化酶（CCO）活性为指标研究了次血红素六肽对心肌线粒体的抗氧化保护作用。结果线粒体氧化损伤模型而中MDA生成量随着时间的延长而增大,表现为532nm处光吸收值的上升;DhHP-6保护组MDA生成量程度明显降低;DhHP ...
彭燕 +4 more
doaj
Protective Effect of Probiotic-fermented Gardenia jasminoides Ellis against Alcoholic Oxidative Damage in HepG2 Cells [PDF]
This study was to evaluate the effect of fermented Gardenia jasminoides Ellis by a mixture of Bacillus sp. DU-106 and Lactobacillus plantarum on alcoholic oxidative damage in HepG2 cells.
Bing DU +7 more
core +1 more source
Zhongguo shiyan zhenduanxue, 2009 目的研究氧合血颈动脉灌注在重型颅脑损伤中的作用。方法对28例重型颅脑损伤患者于伤后约3.5天行氧合血颈动脉灌注治疗1周,监测灌注前、中、后的脑组织氧分压（PbtO2）二氧化碳分压（PbtCO2）pH值（pHbt）变化以及伤后3个月格拉斯哥预后评分（GOS）的情况。结果患者经氧合血颈动脉灌注治疗后比治疗前的PbtO2升高 ...
赵萍 +4 more
doaj
袋鼠皮蛋白肽对H2O2诱导人肝细胞LO2氧化损伤的影响 [PDF]
, 2019 为探索袋鼠皮蛋白肽如何修复受H2O2损伤的LO2细胞,通过建立H2O2诱导人肝细胞LO2氧化损伤的模型,研究袋鼠皮蛋白肽对氧化应激损伤的人肝细胞LO2的修复作用。结果表明:袋鼠皮蛋白肽在0～0.5μg/μL浓度范围内不仅对LO2细胞活性没有抑制作用而且显著提高了受损细胞的存活率,改善了细胞的形态;与此同时,显著降低了H2O2诱导的丙二醛释放,降低了蛋白质羰基含量和活性氧的水平,使细胞受氧化损伤的影响减小。厦门大学横向课题(XDHT2017407A ...
何庆 +4 more
core
Hericium erinaceus Compound Beverage and Its Ameliorative Effect on Alcohol-induced Oxidative Injury in Rats [PDF]
Objective: To develop a Hericium erinaceus beverage and investigate its protective effect on alcohol-induced gastric mucosa injury in vivo. The antioxidant properties were possessed by H. erinaceus, and the gastrointestinal tract was protected.
Chenglin WU +8 more
core +1 more source
Zhongguo shiyan zhenduanxue, 2007 目的探讨急性肾缺血再灌注损伤过程氧化侵袭与肾细胞凋亡在肾损伤发生机制中的作用。方法采用摘除大鼠左肾,钳夹右侧肾蒂的方法,制成急性缺血再灌注肾损伤模型,测定GSH-Px、SOD活性和MDA含量及检测肾细胞凋亡率。结果缺血再灌注不同时期肾组织SOD活力水平降低,与对照组相比差异显著 ...
周高标, 徐淑艳, 王伟刚, 洪泉
doaj
Preparation and Characterization of Antioxidant Peptides from Pumpkin Seeds and Their Protective Effect against H2O2-induced Damage in Caco-2 Cells [PDF]
In this study, antioxidant peptides were prepared from defatted pumpkin seeds and purified by ultrafiltration and reverse-phase high performance liquid chromatography (RP-HPLC).
HAN Xunze, YU Wenjun, ZHANG Yu, ZHAO Jing, LI Quanhong
core +1 more source