Results 11 to 20 of about 3,852,262 (100)
Systematic Analysis of Long Non-Coding RNA Genes in Nonalcoholic Fatty Liver Disease
Non-Coding RNA, 2022 The largest solid organ in humans, the liver, performs a variety of functions to sustain life. When damaged, cells in the liver can regenerate themselves to maintain normal liver physiology. However, some damage is beyond repair, which necessitates liver
M. Ilieva +6 more
semanticscholar +1 more source
RNA Biology, 2021 The zinc finger CCHC-type (ZCCHC) superfamily proteins, characterized with the consensus sequence C-X2-C-X4-H-X4-C, are accepted to have high-affinity binding to single-stranded nucleic acids, especially single-stranded RNAs.
Yishu Wang +6 more
semanticscholar +1 more source
Compositional biases in RNA viruses: Causes, consequences and applications
Wiley Interdisciplinary Reviews - RNA, 2021 If each of the four nucleotides were represented equally in the genomes of viruses and the hosts they infect, each base would occur at a frequency of 25%. However, this is not observed in nature.
E. Gaunt, P. Digard
semanticscholar +1 more source
RNA: A publication of the RNA Society, 2020 During breast cancer metastasis, the developmental process epithelial–mesenchymal transition (EMT) is abnormally activated. Transcriptional regulatory networks controlling EMT are well-studied; however, alternative RNA splicing also plays a critical ...
Yushan Qiu +4 more
semanticscholar +1 more source
Mechanistic insights into non-coding Y RNA processing
RNA Biology, 2022 Y RNAs (84–112 nt) are non-coding RNAs transcribed by RNA polymerase III and are characterized by a distinctive secondary structure. Human Y RNAs interact with the autoimmune proteins SSB and RO60 that together form a ribonucleoprotein (RNP) complex ...
Martina Billmeier +7 more
semanticscholar +1 more source
Transcriptional profiling of fission yeast RNA polymerase II CTD mutants
RNA: A publication of the RNA Society, 2021 The carboxyl-terminal domain (CTD) of RNA polymerase II consists of tandem repeats of heptapeptide Y1S2P3T4S5P6S7. The CTD recruits proteins that drive or regulate gene expression. The trafficking of CTD-interacting proteins is orchestrated by remodeling
A. Garg +3 more
semanticscholar +1 more source
RNA Biology, 2022 RNA research and applications are underpinned by in vitro transcription (IVT), but RNA impurities resulting from the enzymatic reagents severely impede downstream applications. To improve the stability and purity of synthesized RNA, we have characterized
Heng Xia +6 more
semanticscholar +1 more source
Cotton plants expressing CYP6AE14 double-stranded RNA show enhanced resistance to bollworms
Transgenic research, 2010 RNA interference (RNAi) plays an important role in regulating gene expression in eukaryotes. Previously, we generated Arabidopsis and tobacco plants expressing double-stranded RNA (dsRNA) targeting a cotton bollworm (Helicoverpa armigera) P450 gene ...
Ying-Bo Mao +4 more
semanticscholar +1 more source
Expanding the Boundaries of RNA Sequencing as a Diagnostic Tool for Rare Mendelian Disease
American Journal of Human Genetics, 2019 Gene-panel and whole-exome analyses are now standard methodologies for mutation detection in Mendelian disease. However, the diagnostic yield achieved is at best 50%, leaving the genetic basis for disease unsolved in many individuals.
Hernan Gonorazky +17 more
semanticscholar +1 more source
TRIM25 and its emerging RNA‐binding roles in antiviral defense
Wiley Interdisciplinary Reviews - RNA, 2020 The innate immune system is the body's first line of defense against viruses, with pattern recognition receptors (PRRs) recognizing molecules unique to viruses and triggering the expression of interferons and other anti‐viral cytokines, leading to the ...
Nila Roy Choudhury +2 more
semanticscholar +1 more source