Results 31 to 40 of about 3,852,262 (100)

Single-cell triple omics sequencing reveals genetic, epigenetic, and transcriptomic heterogeneity in hepatocellular carcinomas

Cell Research, 2016
Single-cell genome, DNA methylome, and transcriptome sequencing methods have been separately developed. However, to accurately analyze the mechanism by which transcriptome, genome and DNA methylome regulate each other, these omic methods need to be ...
Yu Hou, Huahu Guo, Chen Cao, Xianlong Li, Boqiang Hu, Ping Zhu, Xinglong Wu, Lu Wen, Fuchou Tang, Yanyi Huang, Jirun Peng   +10 more
semanticscholar   +1 more source

piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans

Cell, 2012
Summary Transgenerational effects have wide-ranging implications for human health, biological adaptation, and evolution; however, their mechanisms and biology remain poorly understood.
A. Ashe, A. Sapetschnig, Eva-Maria Weick, Jacinth Mitchell, Marloes P. Bagijn, A. Cording, Anna-Lisa Doebley, Leonard D. Goldstein, N. Lehrbach, J. Le Pen, G. Pintacuda, A. Sakaguchi, P. Sarkies, Shawn Ahmed, E. Miska   +14 more
semanticscholar   +1 more source

Cap-specific, terminal N6-methylation by a mammalian m6Am methyltransferase

Cell Research, 2018
Dear Editor, Dynamic and reversible N-methyladenosine (mA) RNA methylation has been found to greatly impact gene expression, leading to the field of epitranscriptomics.
Hanxiao Sun, Meiling Zhang, Kai Li, Dongsheng Bai, C. Yi   +4 more
semanticscholar   +1 more source

Roles for miRNAs in osteogenic differentiation of bone marrow mesenchymal stem cells

Stem cell research & therapeutics, 2019
Bone marrow mesenchymal stem cells (BMSCs), which were first discovered in bone marrow, are capable of differentiating into osteoblasts, chondrocytes, fat cells, and even myoblasts, and are considered multipotent cells. As a result of their potential for
Jicheng Wang, Shizhang Liu, Jingyuan Li, Song Zhao, Zhi Yi   +4 more
semanticscholar   +1 more source

Mechanism of Action of circRNA/miRNA Network in DLBCL

Non-Coding RNA
Circular RNAs (circRNAs) make up approximately 10% of the human transcriptome. CircRNAs belong to the broad group of non-coding RNAs and characteristically are formed by backsplicing into a stable circular loop.
Elena Golovina, Cory Eaton, Virginia Cox, Jozef Andel, Karina Savvulidi Vargova   +4 more
semanticscholar   +1 more source

Experimental optimisation of various cultural conditions on urease activity for isolated Sporosarcina pasteurii strains and evaluation of their biocement potentials

, 2017
Microbially induced carbonate precipitation (MICP) is a process that has emerged as an attractive alternative ground improvement technique in Geotechnical and Civil Engineering using ureolytic bacteria for soil strengthening and stabilisation.
A. Omoregie, G. Khoshdelnezamiha, Nurnajwani Senian, D. Ong, P. M. Nissom   +4 more
semanticscholar   +1 more source

Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight

Nature Communications
Microgravity is associated with immunological dysfunction, though the mechanisms are poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear cells (PBMCs) exposed to short term (25 hours) simulated microgravity, we ...
Fei Wu, Huixun Du, Eliah G. Overbey, Jangkeun Kim, Priya Makhijani, Nicolas Martin, Chad A. Lerner, Khiem Nguyen, Jordan J. Baechle, Taylor R. Valentino, Matías Fuentealba, Juliet M. Bartleson, Heather Halaweh, S. Winer, Cem Meydan, Francine E. Garrett-Bakelman, N. Sayed, Simon Melov, M. Muratani, A. Gerencser, Herbert G. Kasler, Afshin Beheshti, Christopher E. Mason, D. Furman, Daniel A. Winer   +24 more
semanticscholar   +1 more source

AUGcontext DB: a comprehensive catalog of the mRNA AUG initiator codon context across eukaryotes

RNA Biology
The mRNA translation defines the composition of the cell proteome in all forms of life and diseases. In this process, precise selection of the mRNA translation initiation site (TIS) is crucial, as it establishes the correct open reading frame for triplet
Vincent G. Osnaya, Laura Gómez-Romero, Gabriel Moreno-Hagelsieb, Greco Hernández   +3 more
semanticscholar   +1 more source

miRNA genetic variations associated with the predisposition of oral squamous cell carcinoma in central Indian population

Non-coding RNA Research
The disease burden of Oral Squamous Cell Carcinoma (OSCC) is rising day-by-day and is expected to rise 62 % through 2035. The chewing of tobacco, areca nut, and betel leaf, poor oral hygiene, and chronic infection are common risk factors of OSCC, but ...
Shikha Tiwari, R. Pandey, Vinay Kumar, Saikat Das, Vikas Gupta, R. Nema, Ashok Kumar   +6 more
semanticscholar   +1 more source

Comprehensive processing of high-throughput small RNA sequencing data including quality checking, normalization, and differential expression analysis using the UEA sRNA Workbench.

RNA: A publication of the RNA Society, 2017
Matthew Beckers, I. Mohorianu, Matthew B. Stocks, Christopher Applegate, T. Dalmay, V. Moulton   +5 more
semanticscholar   +1 more source