Results 91 to 100 of about 8,323 (166)
O2‐Accessible Fe–N4 Active Site Density Boosts Efficient Oxygen Reduction to Fuel‐Cell Level
Advanced Materials, Volume 38, Issue 16, 17 March 2026.This study investigates the role of hierarchical nanostructure design in optimizing oxygen mass transport for the oxygen reduction. Using atomically dispersed Fe–N–C catalysts with solid, yolk‐shell, and hollow structures, it demonstrates that the yolk‐shell architecture provides superior O2 accessibility to active Fe–N4 sites.
Tianyu Zhang +7 more
wiley +1 more source
Advanced Science, Volume 13, Issue 16, 18 March 2026.This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen +11 more
wiley +1 more source
Advanced Science, Volume 13, Issue 17, 23 March 2026.A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu +6 more
wiley +1 more source
Jianzhu Gangjiegou Jinzhan, 2004 <正> 受中国建筑金属结构协会和中国钢结构协会委托,由天津大学主办,清华大学、浙江大学、北京工业大学、同济大学、上海交通大学、太原理工大学、哈尔滨工业大学协办的第四届全国现代结构工程学术研讨会定于2004年7月21至24日在浙江宁波召开。会议由浙江精工钢结构建设集团有限公司承办。
doaj
浙江大学学报. 医学版神经退行性变性疾病是一组以中枢或周围神经系统神经元的功能和结构完整性逐渐丧失为特征的神经系统疾病。这类疾病的病因复杂，致病机制及药物靶点的研究仍面临诸多难题。转运RNA（tRNA）修饰在调节密码子识别、维持分子结构稳定性以及影响tRNA衍生片段（tRF）产生等方面发挥着关键作用，对神经发育和神经系统的生理功能具有重要作用。异常的tRNA修饰与多种神经退行性变性疾病的发病机制密切相关，特别是延伸因子复合物依赖的tRNA修饰和甲基化修饰异常能导致翻译过程和tRF水平变化，进而干扰蛋白质稳态和细胞应激反应 ...
唐 明敏 +3 more
doaj +1 more source
Advanced Science, Volume 13, Issue 16, 18 March 2026.PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia +14 more
wiley +1 more source
S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning
Advanced Science, Volume 13, Issue 17, 23 March 2026.Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu +6 more
wiley +1 more source
[Screening and clinical analysis of isovaleric acidemia newborn in Zhejiang province]. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue Ban, 2020 Hu Z +6 more
europepmc +1 more source
Mathematical Prediction for Geometry‐Mediated Cell 3D In‐Growth on Bone Tissue Engineering Scaffolds
Advanced Science, Volume 13, Issue 14, 9 March 2026.This study identifies a fundamental pore size dependent pattern of three dimensional bone marrow derived mesenchymal stem cell (BMSC) infiltration within porous scaffolds, where small pores promote horizontal cellular bridging and large pores facilitate vertical migration.
Xiang Gao +15 more
wiley +1 more source
Advanced Science, Volume 13, Issue 16, 18 March 2026.A real‐time, high‐definition hyperspectral endoscopy is enabled by developing a spatial‐temporal spectral encoding approach based on low‐frequency stochastic filters combined with an encoding‐guided attention network. It provides hyperspectral image of in vivo tissue with fine superficial features, enables visualization of rapid and subtle ...
Xiaowei Liu +11 more
wiley +1 more source