Results 101 to 110 of about 319,333 (182)
Experimental Physiology, EarlyView.Abstract IgA nephropathy (IgAN) is a common type of primary glomerulonephritis in children. The pathogenesis of childhood IgAN remains unclear, and there is a lack of effective non‐invasive biomarkers for this disease. Single‐cell RNA sequencing was performed in children with IgAN to delineate cellular and molecular compositions, and subcluster ...
Ling Yu +7 more
wiley +1 more source
野生动物学报, 1986 黄腹角雉（Tragopan caboti）为我国特产珍禽、国家一类保护动物,分布于福建、广东、广西、浙江、江西及湖南等省的局部地区,数量已极为稀少。它的典型栖息地为亚热带常绿阔叶林及针阔混交林,海拔1,000～1,400米的山中 ...
郑光美
doaj
[Management of COVID-19: the Zhejiang experience]. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue Ban, 2020 Xu K +16 more
europepmc +1 more source
DEN Open, Volume 7, Issue 1, April 2027.ABSTRACT Background While the Updated Sydney System classifies Helicobacter pylori density together with inflammatory scores, the clinical relevance of bacterial load remains uncertain. This study aimed to assess the association between histological H. pylori density and the severity of gastric inflammatory activity.
Guochun Lou +5 more
wiley +1 more source
, 2006 本研究对长江江豚性成熟、繁殖季节以及性周期等方面的生殖激素变化规律进行了比较全面的探讨；同时还初步建立了对江豚粪便类固醇激素的检测分析方法，并对3头豢养江豚的粪便激素进行了周年监测研究。本研究主要获得如下几个方面的结论： 1）性成熟 雄性长江江豚达到性成熟的体长约在134 cm 到 138 cm之间；未成熟雄性江豚血清睾丸酮水平为17.3 ± 27.9 ng/dL，青春期和性成熟后血清基础值为217.8 ± 276.8 ng/dL，繁殖季节可攀升到1214.3 ± 452.9 ng/dL ...
郝玉江
core
浙江大学学报. 医学版研究表明，铁代谢和铁死亡影响了髓系肿瘤的发生发展，可以作为其治疗靶点。铁代谢失调存在于多种髓系肿瘤中：急性髓系白血病的预后与铁代谢分子的差异表达相关；伴随铁过载的骨髓增生异常综合征患者预后不良；骨髓增殖性肿瘤常表现为缺铁和红细胞增多共存，可通过靶向铁调素进行治疗。髓系肿瘤细胞容易受到活性氧积累的影响而发生氧化损伤，具有铁死亡敏感性。在急性髓系白血病和骨髓增生异常综合征中，铁死亡均具有抗肿瘤作用；在慢性髓系白血病中，靶向铁死亡可以逆转伊马替尼耐药。本文综述了髓系肿瘤发生发展中铁代谢水平的特征 ...
王 雨涤 +3 more
doaj +1 more source
Advanced Science, Volume 13, Issue 55, 5 October 2026.Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang +16 more
wiley +1 more source
Shuitu Baochi Xuebao, 2005 在明确人与自然关系的生态伦理基础上,提出实现经济生态化和生态经济化是浙江建设生态省的关键,做到“三生共赢”是实现人与自然和谐相处 ...
张文和
doaj +2 more sources
Advanced Science, Volume 13, Issue 56, 9 October 2026.GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han +16 more
wiley +1 more source
浙江大学学报. 医学版信使RNA（mRNA）疗法是一种将体外转录的mRNA递送至特定细胞，生成目标蛋白以治疗或预防疾病的生物技术。mRNA疗法离不开有效的mRNA递送系统，而脂质纳米粒（LNP）是目前临床应用最为广泛的一类mRNA递送载体。LNP由可电离脂质、两性磷脂、胆固醇和聚乙二醇化脂质四种脂质材料组成，可有效解决mRNA药物存在的体内稳定性较差、难以跨越体内多级生物屏障等难题，并能够针对肝脏、肺和脾脏等器官实现mRNA安全、高效和靶向递送。本文阐述了LNP四种脂质组分在递送mRNA中的作用，介绍了通过抗体修饰 ...
何 顺, 刘 帅
doaj +1 more source