Results 91 to 100 of about 8,473 (140)
野生动物学报, 2004 浙江省野生动植物资源丰富,对外贸易活跃。据统计,2003年浙江省野生动植物及其产品贸易额达24.5亿元,比前两年有大幅增加（2001年为19亿元,2002年为21.5亿元）,这充分说明野生动植物对外贸易已日益成为浙江省经济发展的一大新亮点。研究分析野生动植物进出口中的基本情况、及时发现新问题、制定新对策,已成为当前进一步规范野生动植物进出口管理的重要课题。
王章明
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Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives
MedComm, Volume 7, Issue 8, August 2026.The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng +9 more
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浙江大学学报. 医学版信使RNA（mRNA）疗法是一种将体外转录的mRNA递送至特定细胞，生成目标蛋白以治疗或预防疾病的生物技术。mRNA疗法离不开有效的mRNA递送系统，而脂质纳米粒（LNP）是目前临床应用最为广泛的一类mRNA递送载体。LNP由可电离脂质、两性磷脂、胆固醇和聚乙二醇化脂质四种脂质材料组成，可有效解决mRNA药物存在的体内稳定性较差、难以跨越体内多级生物屏障等难题，并能够针对肝脏、肺和脾脏等器官实现mRNA安全、高效和靶向递送。本文阐述了LNP四种脂质组分在递送mRNA中的作用，介绍了通过抗体修饰 ...
何 顺, 刘 帅
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Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer
Cancer Science, Volume 117, Issue 8, Page 2064-2084, August 2026.Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo +6 more
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浙江大学学报. 医学版神经退行性变性疾病是一组以中枢或周围神经系统神经元的功能和结构完整性逐渐丧失为特征的神经系统疾病。这类疾病的病因复杂，致病机制及药物靶点的研究仍面临诸多难题。转运RNA（tRNA）修饰在调节密码子识别、维持分子结构稳定性以及影响tRNA衍生片段（tRF）产生等方面发挥着关键作用，对神经发育和神经系统的生理功能具有重要作用。异常的tRNA修饰与多种神经退行性变性疾病的发病机制密切相关，特别是延伸因子复合物依赖的tRNA修饰和甲基化修饰异常能导致翻译过程和tRF水平变化，进而干扰蛋白质稳态和细胞应激反应 ...
唐 明敏 +3 more
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Journal of Cellular and Molecular Medicine, Volume 30, Issue 16, August 2026.ABSTRACT Oral submucous fibrosis (OSF) is a chronic, progressive, premalignant disorder with expanding epidemiology, rising annual incidence, and increasing malignant transformation rates. Therefore, elucidating its pathogenesis and establishing early intervention strategies remain urgent priorities.
Chunyu Li +6 more
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Jianzhu Gangjiegou Jinzhan, 2004 <正> 受中国建筑金属结构协会和中国钢结构协会委托,由天津大学主办,清华大学、浙江大学、北京工业大学、同济大学、上海交通大学、太原理工大学、哈尔滨工业大学协办的第四届全国现代结构工程学术研讨会定于2004年7月21至24日在浙江宁波召开。会议由浙江精工钢结构建设集团有限公司承办。
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Clinical characteristics and plasma antibody titer of patients with COVID-19 in Zhejiang, China. [PDF]
J Zhejiang Univ Sci B, 2020 Xiang WL +9 more
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[Impact of outpatient services utilization of heart failure patients on hospitalization rate and its threshold effect: Taking patients with Urban Employee Basic Medical Insurance in Zhejiang Province as an example]. [PDF]
Beijing Da Xue Xue Bao Yi Xue BanZhang H, Jing R, Wang J, Fang H.
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[Association between factors in life course and physiological dysregulation among the middle-aged and older population in Zhoushan city of Zhejiang province]. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue BanCao X +9 more
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