Results 31 to 40 of about 594,054 (108)
Veterinary Dermatology, Volume 36, Issue 4, Page 453-461, August 2025.Background – Canine atopic dermatitis (cAD) is a chronic, inflammatory, multifactorial and pruritic disease. The presence of skin barrier impairment (e.g. filaggrin alterations), along with abnormal immune responses, can negatively impact cutaneous barrier function.
Wendie Roldan Villalobos +5 more
wiley +1 more source
, 2008 细胞粘附分子间相互作用介导了炎症反应、肿瘤转移、动脉硬化和创伤愈合等重要生物学过程,定量描述为受体-配体结合和解离的二维反应动力学。反应动力学参数-分子结合时的正反应率和解离时的负反应率-决定着分子反应发生的可能性、快慢和键的强弱 ...
孙淦云, 龙勉, 章燕
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, 2009 炎症反应贯穿动脉粥样硬化(atherosclerosis,AS)发生、发展及易损斑块形成和破裂的全过程。中医毒邪致病理论,即外来之毒与内生之毒相互作用产生的痰毒、瘀毒、热毒在粥样斑块的形成中起重要作用,说明炎症反应贯穿"痰瘀热毒"产生的全过程,痰毒、瘀毒和热毒作为病邪又可诱发机体炎症反应,这样反复循环,可致粥样斑块形成和不断增大。因此,AS发生 ...
吕崇山, 董欢
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Veterinary Dermatology, Volume 36, Issue 2, Page 165-176, April 2025.Background – Janus kinase inhibitors (JAKi) have been shown to reduce pruritus and improve associated inflammatory skin lesions in canine atopic dermatitis (cAD). Objective – To evaluate the efficacy and safety of ilunocitinib, in comparison to oclacitinib, for the control of cAD in a randomised, blinded trial.
Sophie Forster +4 more
wiley +1 more source
Long‐term use of lokivetmab in dogs with atopic dermatitis
Veterinary Dermatology, Volume 35, Issue 6, Page 683-693, December 2024.Background – Lokivetmab, a caninised monoclonal antibody against interleukin (IL)‐31, is an effective treatment for the pruritus associated with canine atopic dermatitis (cAD). Objectives – To investigate the efficacy and safety of lokivetmab during long‐term treatment defined as at least three consecutive lokivetmab injections in atopic dogs under ...
Bettina Kasper +2 more
wiley +1 more source
Veterinary Dermatology, Volume 35, Issue 5, Page 500-507, October 2024.Abstract Background Canine atopic dermatitis (cAD) is a hereditary, generally pruritic and predominantly T‐cell‐driven inflammatory skin disease, involving an interplay between skin barrier abnormalities, allergen sensitisation and microbial dysbiosis.
L. Widorn +2 more
wiley +1 more source
, 2015 目的缺氧所致血管炎症反应的分子机制目前尚不清楚。研究表明,O-乙酰氨基葡萄(O-GlcNAc)转移酶(OGT)在炎症反应中可能起着非常重要的调控作用。本研究旨在探讨OGT在缺氧所致血管内皮炎症反应中的作用。方法缺氧模型细胞为暴露于1%O_2或氯化钴(Cobalt,200μg/ml)后的血管内皮细胞。研究发现,缺氧刺激后内皮细胞中缺氧诱导因子-1α(HIF-1α)的蛋白表达迅速上调,相关炎症因子(IL-6、IL-8、MCP-1及E-选择素)在转录及翻译水平上的表达亦显著增加 ...
郑军平 +5 more
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Veterinary Dermatology, Volume 35, Issue 4, Page 418-431, August 2024.Background – Diagnosis of canine adverse food reactions (AFRs) is based on vague criteria, such as ‘>50% improvement’ during elimination diet trial (EDT) followed by ‘deterioration’ during provocation test (PT). Objective – The objective of the study was to use predefined criteria to evaluate response during EDT [i.e., Owner Global Assessment of ...
Evi I. Sofou +4 more
wiley +1 more source
, 2014 壳寡糖可抑制有害刺激如内毒素、细菌、细胞因子等引起的炎症反应，如壳寡糖可通过阻断NF-κB通路的激活抑制LPS诱导的内皮细胞炎症反应。但是，壳寡糖如何发挥抗炎活性及其背后深入的作用机制尚不完全清楚。转录因子NF-κB p65亚基存在多种翻译后修饰：磷酸化，乙酰化，泛素化及O-GlcNAc糖基化修饰等。NF-κB的翻译后修饰会影响其对相关炎症因子转录的调节作用。因此，本论文通过构建LPS诱导的炎症模型，研究壳寡糖对NF-κB翻译后修饰，尤其是磷酸化和O-GlcNAc糖基化修饰的影响 ...
李昱
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, 2013 【目的】 探讨高糖通过诱导内质网应激(ERS)引起人脐静脉内皮细胞(EAhy926)炎症反应的作用机制?【方法】人脐静脉内皮细胞给予正常浓度糖(5.5 mmol/L)或高浓度糖(25 mmol/L)干预0?2?4?8?12 h,或ERS诱导剂毒胡萝卜素(TG)0.5 μmol/L干预24 h?Western blot检测下列蛋白表达水平:细胞间黏附因子-1(ICAM-1)?肿瘤坏死因子-α(TNFα)等炎症因子;葡萄糖调节蛋白78(GRP78)?磷酸化真核细胞翻译起始因子2α(p-eIF2α ...
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