Results 21 to 30 of about 48,487 (167)

Tolerability and Feasibility of Minimally Invasive Canine Skin Sampling: Excellent Tolerability Meets Transcriptomic Challenges

open access: yesVeterinary Dermatology, EarlyView.
ABSTRACT Background Advances in transcriptomics have driven the demand for minimally invasive, reproducible and high‐yield skin sampling methods, particularly for studying inflammatory skin diseases in companion animals. Hypothesis/Objectives We tested tolerability, feasibility and RNA quantity and quality of three minimally invasive skin sampling ...
Ina Herrmann   +2 more
wiley   +1 more source

NLRP3 炎症小体与心血管疾病

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2017
炎症小体是一类多蛋白复合物,主要由识别炎症的胞浆型模式识别受体、衍接蛋白和效应蛋白三部分组成。 炎症小体组装激活可以自我切割生成活性形式的caspase-1,并进一步促进白细胞介素-1β(IL-1β)和白细胞介素-18(IL- 18)等炎症因子的成熟和释放,引起炎症反应。此外炎症小体激活可介导caspase-1依赖的细胞焦亡,从而促进炎症反应的 扩散。炎症小体根据识别信号的模式识别受体命名,其中NLRP3炎症小体是目前研究最多了解相对最清楚的炎症小体 ...
谭红梅
doaj  

Mindin is up-regulated during colitis and enhances inflammation by activating the transcription activity of NF-κB protein family [PDF]

open access: yes, 2015
炎症性肠病(IBD)的发生,被认为是遗传、环境和黏膜免疫三方面因素共同作用的结果,而肠黏膜异常的免疫应答又是发病的关键因素之一。在炎症局部,炎性细胞的招募和激活依赖各种细胞膜受体及整合素与细胞基质(ECM)间的相互作用。细胞外基质蛋白Mindin是Mindin/F-spondin家族成员,在小鼠炎症模型中,有多项研究表明Mindin在免疫应答过程中扮演重要角色,但对于其在炎症中的功能和调控机制研究较少。故本课题拟探索肠炎中Mindin的表达水平及其在炎症中的信号调控机制。 本课题研究中 ...
李萍
core  

Effect of a Spray Containing Occlusive Agents, Humectants and Physiological Lipids on Skin Hydration of Healthy Dogs When Applied After Bathing With a Chlorhexidine 2%/Miconazole 2% Shampoo

open access: yesVeterinary Dermatology, Volume 37, Issue 1, Page 140-147, February 2026.
Background: Normal hydration of the canine epidermis is imperative for cutaneous homeostasis. Xerosis may be encountered in canine atopic dermatitis and may be aggravated by topical antiseptics. Hypothesis and Objectives: To evaluate the hydrating properties and the safety of a spray (Sensiderm spray; MP Labo) when applied after shampooing healthy dogs
Adamantia Pseftogka   +3 more
wiley   +1 more source

血清IL-6、TNF-α、IL-10的动态监测在儿童重症肺炎中临床意义

open access: yesZhongguo shiyan zhenduanxue, 2015
肺炎是儿童的常见疾病,其中有7%-13%是重症肺炎[1],与其他炎症一样,肺炎本是一种局部的感染炎症。若感染未得到控制,肺部受累面积较大,不仅导致低氧血症及高碳酸血症,同时病原微生物侵入气道后,支气管及肺泡巨噬细胞吞噬、杀灭病原体并对病原体加工处理,将抗原信息提呈给T淋巴细胞,同时释放大量细胞因子(cytokine,CK)等参与炎症反应,促炎与抑炎反应的平衡 ...
黄光举   +4 more
doaj  

プロスタグランジンF受容体選択的阻害薬AS604872は高血圧ラットにおいて脳動脈瘤と大動脈解離を増悪させる [PDF]

open access: yes, 2016
京都大学0048新制・課程博士博士(医学)甲第19397号医博第4048号新制||医||1012(附属図書館)32422京都大学大学院医学研究科医学専攻(主査)教授 渡邊 直樹, 教授 小泉 昭夫, 教授 木村 剛学位規則第4条第1項該当Doctor of Medical ScienceKyoto ...
Fukuda, Miyuki
core   +1 more source

Developing a Linguistically Valid Japanese Version of the Chronic Pain Attribution Scale: Translation and Cultural Adaptation Process

open access: yesNeuropsychopharmacology Reports, Volume 45, Issue 4, December 2025.
This study reports the development and linguistic validation of the Japanese version of the Chronic Pain Attribution Scale. The tool captures culturally nuanced beliefs about chronic pain causes and provides a foundation for research on treatment responses in Japanese‐speaking populations.
Keiko Yamada   +8 more
wiley   +1 more source

2型生物制剂和亚洲慢性鼻窦炎

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2022
慢性鼻窦炎(CRS)是一种高异质性疾病,不同种族和地域的CRS患者表现为不同的流行病学和内在型特征。尽管经历了充分和规律的药物和手术治疗,仍有相当比例的CRS患者治疗后复发。复发性、难治性CRS为CRS的临床治疗提出了严峻挑战。2型生物制剂的问世,为难治性、复发性CRS的治疗带来了曙光。近年来,靶向2型炎症的生物制剂在治疗西方国家患者的难治性CRS方面表现出了令人鼓舞的治疗效果。但是由于炎症特征存在异质性,西方CRS患者以嗜酸粒细胞性2型炎症为主,而亚洲CRS患者更多地表现为1型炎症 ...
白瑜蓉, 张雅娜
doaj  

Adverse neonatal outcomes in small‐for‐gestational age twins identified using twin vs singleton growth charts: systematic review and meta‐analysis

open access: yesUltrasound in Obstetrics &Gynecology, Volume 66, Issue 6, Page 706-715, December 2025.
ABSTRACT Objective To evaluate the use of twin vs singleton growth charts for detecting small‐for‐gestational‐age (SGA) twins at risk of adverse neonatal outcomes. Methods MEDLINE, EMBASE, CINAHL, Cochrane and Scopus databases were searched electronically from inception to May 2024.
S. Sorrenti   +9 more
wiley   +1 more source

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