Results 91 to 100 of about 2,155 (170)
Study on the action mechanism of lncRNA MIAT/miR-384-5p in rats with acute myocardial infarction [PDF]
Objective To investigate the role and molecular mechanism of lncRNA MIAT inhibition in acute myocardial infarction (AMI) in rats. Methods Sixty male Sprague-Dawley (SD) rats were randomly divided into sham, AMI, AMI+si-NC, AMI+si-MIAT, AMI+si-MIAT+miR-NC
CHEN Huibin, JIAN Jie, LI Can
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Thapsigargin对人晶状体上皮细胞系SRA01／04增殖抑制的作用机制
Zhongshan Daxue xuebao. Yixue kexue ban, 2007 【目的】研究thapsigargin（TG）对体外培养的人品状体上皮细胞系SRA01／04增殖的影响，并探讨其分子机制。【方法】不同浓度TG处理SRA01／04细胞72h，噻唑蓝比色法（MTT）检测细胞增殖；流式细胞仪（PI法）检测细胞周期改变；透射电镜观察细胞超微结构变化；TUNEL法检测细胞核中DNA的断裂情况；激光共焦显微镜和流式细胞仪检测Caspase3活性亚单位（17／19ku）的表达及阳性细胞表达率。【结果】MTT法测得TG为0．325～5μmol／L时，细胞增殖抑制率变化显著 ...
姬红培, 吴明星, 彭瑞萍
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Mechanism of Huanglian Wendan Decoction in treatment of pelvic inflammatory disease based on network pharmacology and molecular docking technology [PDF]
Objective To explore the mechanism of Huanglian Wendan Decoction in the treatment of pelvic inflammatory disease using network pharmacology and molecular docking technology.
GAO Xiuan +4 more
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Application of pyroptosis score in the treatment and prognosis evaluation of gastric cancer. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2023 Li L, Liao A.
europepmc +1 more source
Progress in epigenetic modification of ferroptosis involved in chronic obstructive pulmonary disease [PDF]
Ferroptosis is a special type of programmed cell death, which is different from autophagy, apoptosis and other modes of death, and characterized by mitochondrial shrinkage, membrane density increase and ridge reduction.
CAI Xiaoyu +3 more
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焦虑抑郁障碍对女性冠心病患者血清CA125和TNF-α表达的影响
Zhongguo shiyan zhenduanxue, 2019 冠状动脉疾病是临床最常见的心血管疾病,其中冠心病（CHD）是冠状动脉疾病最严重的临床表现,也是全世界最常见的死因[1]。在美国,2011年共有375295人死于CHD,大约每分钟有24人发病和1人死亡[2]。CHD主要是由多基因遗传变异和环境因素共同导致的严重疾病[3]。目前,冠状动脉造影,心脏磁共振扫描,血清/血浆生物标志物等已经被广泛应用于CHD的诊断[4]。CHD快速精确的诊断能够明显改善病人预后和生活质量。许多因素与CHD发病有关,包括血浆脂质浓度、血压、吸烟、糖尿病和炎症标志物等[5 ...
刘永政, 郜琳, 王倩
doaj
Zhongshan Daxue xuebao. Yixue kexue ban肺移植（LTx），是治疗终末期肺疾病（ESLD）唯一有效的根治性治疗手段，适用于药物和其他手术治疗无效的晚期肺病患者，可显著改善患者预后。但LTx仍面临诸多挑战，如缺血再灌注损伤（IRI）、长期生存率低等。改善肺IRI对移植术后肺功能的恢复和患者预后有重要意义。肺IRI是指肺组织经历血流中断（缺血）后恢复供血（再灌注）时，反而加重的组织损伤和炎症反应。IRI是导致原发性移植物功能障碍（PGD）的重要病理生理基础，其损伤机制复杂多样，涉及多种细胞死亡的激活。程序性细胞死亡（PCD）是细胞受基因调控发生的 ...
虞燕青, 孙煦勇
doaj
Zhongguo cuzhong zazhi卒中具有高发病率、高死亡率和高致残率的特点。我国卒中负担沉重，幸存者多遗留运动、认知等功能障碍，而传统康复技术存在一定局限性。在此背景下，神经调控技术正以融合化、闭环化、精准化为主要趋势，引领卒中康复领域的革新。其中，脑机接口（brain-computer interface，BCI）作为当前研究热点，凭借“意念-动作”闭环等独特机制，在卒中康复领域展现出了强劲的潜力。不过，单一神经调控技术的效果较为有限，而多模态融合策略可通过技术协同进一步提升康复疗效，逐渐成为了应用和研究的新趋势 ...
刘丽旭（LIU Lixu ）
doaj +1 more source
Potential role of SUMO-specific proteases 1 in ferroptosis [PDF]
Objective·To explore the potential role of SUMO-specific protease 1 (SENP1) in ferroptosis.Methods·The Cancer Genome Atlas (TCGA) database was used to analyze the correlation between the expression levels of SENP1 and the ferroptosis-related genes, acyl ...
BAI Meng +5 more
core +1 more source
Ghrelin通过JNK信号通路抑制LPS诱导的肺泡巨噬细胞凋亡
Zhongshan Daxue xuebao. Yixue kexue ban, 2015 【目的】 观察体外条件下加入外源性ghrelin对内毒素(LPS)诱导大鼠肺泡巨噬细胞NR8383凋亡以及吞噬能力的影响,并探讨JNK(c-Jun N-terminal kinase)信号通路在其中所起的作用? 【方法】 用CCK-8(Cell Counting Kit-8)法检测加入LPS或者ghrelin与LPS共孵育后NR8383的细胞毒性;流式细胞技术?原位末端标记法(TUNEL)检测细胞凋亡率;Western blot检测JNK?phospho-JNK信号通路蛋白以及cleaved ...
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