Quercetin regulates phenotypic transformation of vascular smooth muscle cells induced by angiotensin Ⅱ through Nrf2/HO-1 signaling pathway [PDF]
ObjectiveTo investigate the protective effect and mechanism of quercetin (QR) against angiotensin Ⅱ (Ang Ⅱ)-induced injury and phenotypic transformation in vascular smooth muscle cells (VSMCs).
Mamatimin ABDURESHIT, Wei ZHU
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Recent Advances in Extraction Methods, Biological Activities and Application in Foods of Puerarin [PDF]
Puerarin is the major bioactive ingredient of Pueraria lobata, a traditional medicinal and edible plant in China, and it exerts multiple biological activities, including cardiovascular protection, anti-diabetes, anti-tumor, neuroprotection, bone ...
HUANG Shihan, LIU Xinyu, LIU Yanxin, XU Huaming, YU Yiting
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NLRP3炎症小体在甲型流感病毒H1N1预感染降低小鼠巨噬细胞抗MRSA免疫中的作用 [PDF]
, 2020 目的研究NLRP3炎症小体在经甲型流感病毒H1N1预感染的小鼠巨噬细胞抗耐甲氧西林金黄色葡萄球菌（MRSA）免疫中的活性及作用。方法以MRSA分别感染小鼠巨噬细胞（MRSA组）和以甲流病毒H1N1预感染1周的巨噬细胞（H1N1+MRSA组），荧光定量PCR检测各组细胞NLRP3、Caspase-1、IL-1β的mRNA表达强度，免疫荧光及western blot检测细胞中NLRP3的蛋白表达强度，ELISA检测细胞上清液IL-1β的浓度。结果MRSA组NLRP3、Caspase ...
吴本权 +5 more
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Effect of ginkgolide B on hepatic ischemia-reperfusion injury in mice with fatty liver disease and its mechanism [PDF]
Objective To investigate the effect of ginkgolide B on hepatic ischemia-reperfusion injury in mice with fatty liver disease and its mechanism. Methods A total of 25 male C57BL/6J mice were fed with 60% high-fat diet for 16 weeks, and then they were ...
HUANG Xijian, ZHAO Jinxin, LUO Lijian, LIU Huan, CAI Jinzhen
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血清CA153、CEA和CA125水平与乳腺癌病情转归的关系分析
Zhongguo shiyan zhenduanxue, 2013 乳腺癌是当今全球女性发病率最高的恶性肿瘤之一,在大中型城市其发病率已超过宫颈癌,成为最高的恶性肿瘤,随着生活水平的提高,我国乳腺癌发病率和死亡率呈逐年增加的趋势,乳腺癌的相关研究日益成为癌症研究领域的关注焦点之一,其中肿瘤标记物的监测对于疾病诊断及预后预测具有重要意义,对乳腺癌术后随访有一定临床意义[1 ...
贾华, 于祥林
doaj
Significant fundamental translational research on breast cancer in China: progress and prospects [PDF]
Breast cancer is the most prevalent malignant tumor that poses a threat to women's health in China, with incidence and mortality rates persistently increasing. Given this critical situation, there is an urgent need to optimize therapeutic options through
LU Yufeng, WANG Han, XIE Yifan, JIANG Yizhou, SHAO Zhimin
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短链脂肪酸通过抑制NLRP3炎症小体介导的焦亡途径减轻糖尿病脑缺血损伤的研究
Zhongguo shiyan zhenduanxue目的探究短链脂肪酸（SCFAs）通过调控NOD样受体蛋白3（NLRP3）炎症小体/半胱天冬酶-1（caspase-1）/消皮素 D（GSDMD）信号通路对糖尿病脑缺血神经功能及焦亡的影响。方法采用高糖高脂喂养联合链脲佐菌素（STZ）注射构建大鼠糖尿病模型，再通过线栓法构建大脑中动脉阻塞（MCAO）大鼠脑缺血模型。造模成功后随机分为3组：糖尿病（DM）组、糖尿病脑缺血（DM+MCAO）组、短链脂肪酸干预（DM+MCAO+SCFAs）组。术后24 h进行以下检测：（1 ...
刘思涵, 徐鹤鸣, 田琳
doaj
Huli yanjiu, 1993 ICU与普通病房相比,收治的患者病情重、生命重危、身体衰弱,其环境特殊与外界隔绝,使患者产生极度的紧张与焦虑,此时,躯体的疼痛更增加患者的痛苦和不安,护士如何帮助患者解除疼痛,是危重病人抢救中一项不可忽视的工作. 1 ICU病人疼痛的原因及影响因素 造成ICU病人躯体疼痛的原因,可以是疾病本身如急性心肌梗死;也可能来自于医源性的,如气管切开.此外,因长期卧床引起的褥疮、便秘、体位不适,肌肉痛等均会引起疼痛.许多研究结果表明,ICU病人的痛感普遍增强,其主要原因是病人对死亡的恐惧,特殊环境造成的焦虑 ...
朱亚丽, 韩蔚
doaj
Agrimoiin promotes NRF2-mediated ferroptosis of gastric cancer cells by inhibiting the PI3K-AKT pathway [PDF]
Objective To observe the inhibitory mechanism of agrimoiin on human gastric cancer cell line HGC-27 and MKN-45. Methods Gastric cancer HGC-27 and MKN-45 cells were divided into control group, different doses of agrimoniin groups, capecitabine (positive ...
CHI Wencheng +4 more
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Study on the action mechanism of lncRNA MIAT/miR-384-5p in rats with acute myocardial infarction [PDF]
Objective To investigate the role and molecular mechanism of lncRNA MIAT inhibition in acute myocardial infarction (AMI) in rats. Methods Sixty male Sprague-Dawley (SD) rats were randomly divided into sham, AMI, AMI+si-NC, AMI+si-MIAT, AMI+si-MIAT+miR-NC
CHEN Huibin, JIAN Jie, LI Can
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