Results 31 to 40 of about 15,066 (234)
[Research Progress on Predictive Biomarkers of Immunotherapy Efficacy in Non-small Cell Lung Cancer]. [PDF]
Zhongguo Fei Ai Za Zhi肺癌是世界上最常见的恶性肿瘤之一，其中非小细胞肺癌（non-small cell lung cancer, NSCLC）占大多数。免疫检查点抑制剂（immune checkpoint inhibitors, ICIs）的出现极大地改变了NSCLC的治疗策略，并改善了患者预后，然而现实中只有少部分患者能够获得长期受益。因此，确定可靠的预测生物标志物对选择治疗方式至关重要。随着近年来分子生物学、基因组测序技术的发展以及对肿瘤及其宿主免疫微环境的认识不断深入，生物标志物的研究层出不穷 ...
Sun T, Chen Z, Wei K, Tang H.
europepmc +2 more sources
[Determination of four oxidative stress biomarkers in human urine using solid-phase extraction coupled with ultra performance liquid chromatography-tandem mass spectrometry]. [PDF]
Se Pu基于超高效液相色谱-串联质谱法(UPLC-MS/MS),建立了人尿液中8-羟基脱氧鸟苷(8-OHdG)、8-羟基鸟苷(8-OHG)、羟基壬烯巯基尿酸(HNEMA)和双酪氨酸(diY)等4种氧化应激生物标志物的测定方法。用水将0.2 mL尿样稀释5倍后,样品经Oasis HLB柱进行富集净化;先用2%(体积分数)甲醇水溶液洗脱diY,再用甲醇洗脱8-OHdG、8-OHG和HNEMA,收集洗脱液后分别进样分析;以甲醇和0.05%(体积分数)乙酸水溶液作为流动相进行梯度洗脱,Acquity UPLC HSS ...
Feng ZZ +6 more
europepmc +2 more sources
British Journal of Dermatology, 2019 特应性皮炎 (AD) 也称为湿疹,是一种常见的炎症性皮肤病,通常在生命早期出现。估计英国有大约 1500 万人目前患有 AD,受此病影响的儿童高达 20%。指标(如患者体内与此病存在或严重性相关的某种特定蛋白的水平)可能在确保治疗得当方面有重要意义。已针对成人描述了 AD的 严重性指标,但需要能够用于定义婴儿 AD 严重性的相似指标,因为婴儿期通常是此病开始的时间。这项研究旨在鉴定易于从婴儿皮肤中获得的可用于预测 AD 的指标。作为此研究的一部分,从 100 名刚发生中重度 AD 但尚未接受治疗的儿童和
Maeve A. McAleer +7 more
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[Biomarkers for Neoadjuvant Immune Checkpoint Inhibitors in Non-small Cell Lung Cancer]. [PDF]
Zhongguo Fei Ai Za Zhi, 2022 外科手术是早中期非小细胞肺癌（non-small cell lung cancer, NSCLC）患者的主要治疗手段。NSCLC的辅助治疗和新辅助治疗在预防疾病复发和控制远处转移具有重要意义。免疫检查点抑制剂（immune checkpoint inhibitors, ICIs）作为新的药物治疗手段已经在晚期NSCLC患者中带来长期生存获益，并在NSCLC新辅助治疗人群中显示出较高的降期率和病理缓解率。但是如何早期识别、鉴定NSCLC ICIs新辅助治疗的获益人群是当前面临的巨大挑战之一。目前 ...
Shu C, Zhu D, Zhou Q.
europepmc +2 more sources
[FCN3 Can Serve as A Potential Biomarker for Prognosis and Immunotherapy of Lung Squamous Cell Carcinoma]. [PDF]
Zhongguo Fei Ai Za Zhi背景与目的 非小细胞肺癌（non-small cell lung cancer, NSCLC）是全球癌症死亡的主要原因。肺鳞状细胞癌（lung squamous cell carcinoma, LUSC）是其重要的病理组织学亚型，免疫逃逸机制复杂，使得免疫治疗的效果有限。Ficolin-3（FCN3）是一种重要的免疫调节分子，它可以通过重塑肿瘤免疫微环境来调节肿瘤的免疫逃逸，但FCN3在LUSC中的作用仍不清楚。本研究使用生物信息学方法对来自癌症基因组图谱（The Cancer Genome Atlas,
Li W, Zu L, Xu S.
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The Anatomical Record, Volume 306, Issue 12, Page 2945-2957, December 2023., 2023 Abstract Incipient diagnosis and noninvasive forecasts using urinary biomarkers are important for preventing diabetic kidney disease (DKD) progression, but they are also controversial. Previous studies have shown a potential relationship between urinary tubular biomarkers (UTBs) and traditional Chinese medicine (TCM) syndrome in patients with DKD. Thus,
Wei Wu +11 more
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Journal of Diabetes, Volume 15, Issue 10, Page 838-852, October 2023., 2023 Highlights This review outlines the history of miRNA discovery and its major advances in the field of metabolism. We explore the roles of miRNAs in diabetes‐related cognitive impairment. We innovatively propose that miRNAs also act with a certain organ‐targeting specificity due to the organ‐targeting nature of extracellular vesicles, which may aid ...
Yining Chao +5 more
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Journal of Diabetes, Volume 15, Issue 9, Page 787-798, September 2023., 2023 Highlights Laparoscopic sleeve gastrectomy and laparoscopic Roux‐en‐Y gastric bypass are effective for reducing weight and improving metabolic parameters in Chinese patients with obesity. These interventions resulted in improved glycemic control, as evidenced by decreased glycated hemoglobin levels, reduced insulin resistance, and improved ...
Wenhuan Feng +6 more
wiley +1 more source
A Review of micro RNAs changes in T2DM in animals and humans miRNAs在2型糖尿病人类和动物中的变化
Journal of Diabetes, Volume 15, Issue 8, Page 649-664, August 2023., 2023 Highlights MicroRNAs (miRNAs) are overexpressed in inflammation, insulin resistance, and type 2 diabetes mellitus (T2DM). Many types of miRNAs are changed during the T2DM progression. miRNAs have a potential role as a biomarker in T2DM diagnosis. Abstract Type 2 diabetes mellitus (T2DM) and its associated complications have become a crucial public ...
Mohammad Reza Afsharmanesh +3 more
wiley +1 more source
Canine melanocytes: Immunohistochemical expression of melanocytic markers in different somatic areas
Veterinary Dermatology, Volume 34, Issue 4, Page 284-297, August 2023., 2023 Background – Melanoblasts originate in the neural crest from where they migrate to peripheral tissues and differentiate into melanocytes. Alteration during melanocyte development and life can cause different diseases, ranging from pigmentary disorders and decreased visual and auditory functions, to tumours such as melanoma.
Ilaria Porcellato +5 more
wiley +1 more source