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启动子DNA甲基化和组蛋白乙酰化对胃癌中PDX1 表达的影响

Zhongshan Daxue xuebao. Yixue kexue ban, 2016
摘 要: 【目的】 已知胃癌中PDX1表达下调,本研究旨在探讨DNA甲基化和组蛋白乙酰化修饰对PDX1基因表达的调控? 【方法】 免疫组化法检测胃癌组织芯片中PDX1?Dnmt1和HDAC的表达,分析其相关性?5’-aza-dC和TSA处理胃癌细胞,RT-PCR检测PDX1 mRNA水平,分析DNA去甲基化和组蛋白乙酰化对PDX1表达的影响;构建6个PDX1启动子片段至pGL3载体,检测转录活性,分析去甲基化和乙酰化对PDX1启动子转录活性的影响 ...
doaj  

[Neutrophil-derived Microvesicles Regulate DNA Methylation of the <i>LINE1</i> Gene in Human Fibroblast-like Synoviocytes]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
Zhao Z, Tang M, Liang Y, Zhang T, Ren Q, Cheng Q, Xiong Y, Ma K, Zhan D.   +8 more
europepmc   +1 more source

乙肝病毒X蛋白对肝癌细胞组蛋白H3K4甲基化修饰的影响及机制

Zhongshan Daxue xuebao. Yixue kexue ban, 2013
【目的】 探讨乙肝病毒X蛋白(HBx)与肝癌细胞组蛋白H3K4位点甲基化修饰的关系及其可能的机制?【方法】构建稳定表达HBx基因的HepG2-hbx及载体对照细胞系HepG2-vc,同时培养用于阳性对照的肝癌细胞系HepG2.2.15及阴性对照细胞系HepG2;用酶标法检测各组细胞组蛋白H3K4位点甲基转移酶活性,比较HBx对H3K4位点甲基转移酶活性的影响;qRT-PCR检测各组细胞中H3K4位点特异性甲基转移酶SMYD3 ( SET and MYND domain containing3 ...
doaj  

Mechanisms of gypenosides in type 2 diabetes mellitus via regulation of m6A methylase METTL3/14 and demethylase FTO. [PDF]

Zhong Nan Da Xue Xue Bao Yi Xue Ban
Li J, Zhang S, Tian R, Tai H, Zhang Y, Hu M, Gong G, Sun J, Wu N.   +8 more
europepmc   +1 more source

[Expression and clinical significance of plasma methylated SEPT 9 gene in patients with primary liver cancer]. [PDF]

Zhonghua Gan Zang Bing Za Zhi, 2023
He N, Feng G, Zhang FN, Hao S, Li R, Zhao ZQ, Tian YW, Yan HL.   +7 more
europepmc   +1 more source

[Role of m6A methylation modification in photoaging and ultraviolet-induced skin cancers]. [PDF]

Zhong Nan Da Xue Xue Bao Yi Xue Ban
Hou Y, Zhang X, Liu J, Wu J.
europepmc   +1 more source

How epigenetics can explain human metastasis A new role for microRNAs [PDF]

, 2009
Amaia Lujambio, Manel Esteller
core  

[Research Progress in the Mechanisms of Acupuncture in Regulating DNA Methylation]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
Gao S, Pan X, Liu B, Luo L, Xiong X, Yu S.   +5 more
europepmc   +1 more source

[Association between <i>MLPH</i> gene hypermethylation in peripheral blood and coronary heart disease]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Jin J, Wang F, Zhu L, Zhao X, Wang J, Zhu C, Yang R.   +6 more
europepmc   +1 more source

[Efficacy analysis of selinexor combined with hypomethylating agent in the treatment of refractory/relapsed acute myeloid leukemia exposed to venetoclax]. [PDF]

Zhonghua Xue Ye Xue Za Zhi, 2023
Zhang J, Song BQ, Kong X, Liu Y, Yang HL, Zong LH, Kong JY, Xu Y, Qiu HY, Wu DP.   +9 more
europepmc   +1 more source