Results 21 to 30 of about 13,118 (169)
A Multifunctional Reducing Molecular Dopant for 16% Efficient Tin Perovskite Solar Cells
ABSTRACT Although lead‐based photovoltaics have seen remarkable progress, tin‐based perovskite solar cells (Sn‐PSCs) continue to face challenges due to their limited power conversion efficiency and insufficient operational stability. The primary cause of this performance gap is the susceptibility of Sn2+ to oxidation, which promotes rapid defect ...
Xianyong Zhou +12 more
wiley +1 more source
The Effects and Mechanisms of JMJD1A on Colorectal Tumorigenesis [PDF]
结直肠癌(colorectalcancer,CRC)是当今世界高发恶性肿瘤之一,多数由散发腺瘤阶段性发展而来,少数结肠癌的发生呈家族性聚集现象或由炎性肠病诱导发生。对结肠癌的早期筛查与诊断是结肠癌防治重点,由于结肠癌患者个体间差异性大,对靶向药物的开发是未来结肠癌治疗的重要辅助手段。 组蛋白去甲基化酶JMJD1A(Jumonjidomaincontaining1A)通过羟基化作用使组蛋白赖氨酸去甲基进而行使转录调节功能,参与精子生成、能量代谢、干细胞更新调控,也参与低氧诱导下的肿瘤调控 ...
苗萌萌
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ABSTRACT Biomass‐derived quinones are promising green and sustainable cathode materials for sodium‐ion batteries (SIBs), yet their practical application is hindered by poor cycling stability due to dissolution in conventional electrolytes. Herein, we demonstrate that sodiumation is an effective strategy to enhance both rate capability and cycling ...
Xinyue Zhu +4 more
wiley +1 more source
Toxicity of BaP exposure during embryonic stage in zebrafish: the mechanisms involved [PDF]
多环芳烃(PolycyclicAromaticHydrocarbon,PAH)是环境中一类分布广泛的持久性有机污染物。苯并(a)芘(Benzo(a)pyrene,BaP)作为代表性的PAH具有包括神经毒性和生殖毒性在内的多种毒性。截至目前,关于BaP神经毒性的研究大多集中于高浓度或短期的暴露实验,而环境水平浓度下、长期的BaP暴露是否能引起同样的神经毒性则研究得较少;此外,胚胎时期低浓度BaP暴露对成年阶段的神经毒性、生殖毒性效应及其机制研究更为少见。因此本研究以斑马鱼为模式动物,分别进行环境水平浓度 ...
高东旭
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ABSTRACT Aqueous vanadium dioxide (VO2)‐based smart thermal insulation coatings represent a viable strategy to decrease building energy consumption and advance sustainable development goals. However, the inherent instability and limited compatibility with polymer matrices of VO2 hinder its widespread application.
Xiuxian Zhao +9 more
wiley +1 more source
The establishment of arsenite-transformed cells (TLECs) and the study on methylation of non-CpG island promoter repressing NQO1 expression in TLECs [PDF]
摘 要 砷及其衍生物广泛分布自然环境并对人类健康构成危害。虽然流行病学研究已经证实长期的砷暴露能诱发多种癌症,但对砷致癌的确切机制目前远未被阐明,需要进一步深入地探索。砷诱导肿瘤形成是一个长期和复杂的过程,相关研究工作首先需要一个合适的细胞模型。为此,我们以低浓度亚砷酸钠长时间处理正常的大鼠肺上皮细胞系(LECs)诱导其转化,再通过一系列的指标实验验证,成功地建立砷转化细胞模型TLECs(Arsenite-transformedLECs),从而为下一步的研究奠定基础 ...
黄宁宇
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ABSTRACT Ni3S2 has emerged as a promising catalyst for the electrochemical oxidation of biomass‐derived 5‐hydroxymethylfurfural (HMF) to 2,5‐furandicarboxylic acid (FDCA), driven by its distinctive physicochemical properties. However, its practical catalytic efficiency is severely hindered by abundant electrochemically inactive surface sites and poor ...
Cheng‐Feng Yi +5 more
wiley +1 more source
Identify the Specific Site for Autoacetylation of Histone Acetyltransferase Gcn5 [PDF]
赖氨酸乙酰化是一种非常重要的转录后蛋白质修饰,如组蛋白乙酰化修饰。乙酰化修饰不仅参与调控基因转录、细胞周期、细胞凋亡和发育,而且在肿瘤的发生、记忆以及能量代谢中发挥重要作用。组蛋白乙酰化酶PCAF(p300/CBP相关因子)和Gcn5(组蛋白乙酰化酶氨合成通用控制蛋白5)都属于GNAT家族,因它们都具有保守的催化结构域故统称为HAT。PCAF/Gcn5主要存在于细胞核内,这样的核定位是由HAT结构域毗连的保守区域自乙酰化状态所决定。然而,自乙酰化在其他同源蛋白中是否也是保守的还不清楚 ...
余姣
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ABSTRACT The high accuracy in surface‐enhanced Raman scattering‐lateral flow immunoassays (SERS–LFIAs) is critical for reliable point‐of‐care testing (POCT) in clinical diagnostics. Conventional approaches are often affected by sampling variability and uneven distribution of immunoprobes, leading to unreliable signal fluctuations.
Shuai Zhao +9 more
wiley +1 more source
Protein Kinase D3 Is Essential for Prostratin-stimulated Integrated HIV-1 Transcription activation via NF- κB Signaling Pathway [PDF]
Prostratin,一种非肿瘤促进性的佛波酯,能够通过激活HIV-1病毒转录来清除潜伏期的HIV-1病毒,但其分子机制还不是很清楚。本文,我们发现PKD3对于Prostratin激活HIV-1病毒转录是必需的。 首先,敲除PKD3能够阻断Prostratin对HIV-1病毒的转录激活,而敲除PKD家族的其他成员则不能。而且过表达持续活性的PKD3,而非野生型或没有催化活性的PKD3,能增强HIV-1病毒转录水平。于此同时 ...
胡向明
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