Results 31 to 40 of about 13,118 (169)
ABSTRACT With the continuous advancement of materials science and technology, the rare metal gallium has increasingly emerged as a promising alternative to the toxic metal mercury. Although existing research has predominantly focused on the high electrical conductivity and excellent deformability of liquid metal (LM), its intrinsic fluidic property ...
Feifan Guo +6 more
wiley +1 more source
Study of N-Phosphorylation on Peptide and Protein-- Preparation of Phosphoramidate and Application of anti-Phosphoarginine Antibody [PDF]
蛋白质有诸多翻译后修饰(post-translationalmodifications,PTMs),包括甲基化、泛素化、乙酰化和磷酸化等等。其中,磷酸化修饰被认为是调控蛋白质功能的重要“开关”,是细胞内信号转导的关键机制,与人类多种疾病的发生密切相关。目前,天然蛋白质中共发现有9种氨基酸可以被磷酸化,其中包括以P-O键连接的磷酸酯类修饰,如磷酸化丝氨酸、苏氨酸和酪氨酸;以P-N键连接的磷酰胺类修饰,如磷酸化组氨酸、精氨酸和赖氨酸;酰基酸化是通过天冬氨酸或谷氨酸的磷酸化形成的,而S ...
孙影
core
ABSTRACT The polyanionic compound Na3V2(PO4)3 (NVP) has emerged as a competitive cathode material for sodium‐ion batteries (SIBs), owing to its high‐voltage redox activity (3.4 V vs. the Na+/Na reference couple) and NASICON‐type framework that enables superior ionic conductivity.
Xiaolei Wu +5 more
wiley +1 more source
Studies of Functions and Mechanisms of JMJD2D in the Development of Colorectal Cancer [PDF]
结直肠癌(Colorectalcancer,CRC)是世界范围内的高发性恶性疾病,其发病率和死亡率呈逐年上升趋势,因而引起广大科研工作者对其发生发展的作用机制进行深入研究。文献报导称,在绝大多数结直肠癌的发生发展过程中都伴随着经典Wnt信号通路的异常激活。该通路激活后,其中最重要的效应分子之一β-Catenin入核与TCF/LEF家族成员结合,激活下游促癌基因转录表达,从而促进结直肠癌的发生发展。 组蛋白赖氨酸特异性去甲基化酶4D(Lysine-specificdemethylase4D,KDM4D ...
余力
core
ABSTRACT Converting CO2 to CH4 under mild conditions is a promising strategy for solving environmental and energy problems, but also a challenge. In this work, the low‐temperature CO2 hydrogenation process over Ni/CeO2 catalysts was significantly accelerated by optimizing the H2 dissociation ability of Ni through the size effect, thus A‐Ni/CeO2 with an
Yu Xie +8 more
wiley +1 more source
Reprogramming of global histone methylation controls the differentiation of monocytes into macrophages [PDF]
单核-巨噬细胞系统由一类具有吞噬功能的免疫细胞组成,包括单核细胞、巨噬细胞及树突状细胞,是机体免疫系统重要的组成之一。来源于造血干细胞的单核细胞在趋化因子激活下,分化为巨噬细胞和树突状细胞,参与机体防卫。目前有关单核-巨噬细胞分化的细胞学过程已基本阐释,然而分化进程中关键分子及其调控网络仍需要深入阐明。此外,单核细胞如果过度增生,会导致正常造血功能衰竭。白血病的发生也与单核-巨噬细胞系统的异常发展有关。因此,深入探索和阐明单核/巨噬细胞形成过程中关键转录因子及其调控网络 ...
王慧敏
core
ABSTRACT Early detection of thermal runaway (TR) is essential for lithium‐ion battery (LIB) safety, as unchecked TR risks catastrophic failures in energy storage systems. Gas‐based sensing offers a faster and more direct approach by detecting decomposition products at the molecular level.
Tianshui Liang +9 more
wiley +1 more source
A Study on Roles of Slit2 in Hepatocellular Carcinoma Cells [PDF]
Slit家族蛋白是一种进化上高度保守的细胞外分泌糖蛋白。对Slit的研究最初的重点是它在神经生长的作用,Slit作为配体通过与跨膜受体Roundabout(Robo)结合在中枢神经系统轴突导向中起到重要的作用。近些年的研究发现Slits与Robos在一些肿瘤中异常表达,说明Slit/Robo信号在肿瘤的发生发展过程中起到重要的作用。 Oncomine数据库的检索结果显示,与正常组织相比,肝细胞癌中受体Robo1的表达量有显著的增加,而Slit2的表达量则有一定的差别,多数情况下表现为下调 ...
朱韦林
core
On the Damage Tolerance of Diffusion Bonded Titanium–Aluminum Phase Biomimetic Composites
ABSTRACT The biomimetic design principles of natural structures involve the strategic integration of stiff and compliant phases to synergistically enhance strength and toughness. Its evolutionary refined natural armor, characterized by a specialized microarchitecture, enables superior damage tolerance.
Shuai Tong +10 more
wiley +1 more source
【目的】探讨JAK/STAT信号转导途径负调控子SHP-1基因启动子区域CpG岛异常甲基化在B细胞淋巴瘤中的意义。【方法】收集存档石蜡包埋组织标本61例(52例B细胞非霍奇金淋巴瘤标本,9例良性增生淋巴结标本),健康人外周血单个核细胞DNA标本15例,用甲基化特异性PCR(methylation-specific PCR,MSP)和非甲基化特异性PCR(unmethylation-specific PCR,un-MSP)检测SHP-1启动子区域CpG岛甲基化状态,MSP、un-MSP和RT ...
汪清铭 +5 more
doaj

