Results 31 to 40 of about 12,974 (167)
The molecular mechanism and biological functions regulation of P2RY1 gene in low differentiated gastric adenocarcinoma [PDF]
, 2016 摘要 背景和目的：P2RY1是细胞膜蛋白受体，ADP及其类似物可以激活该受体。近期的研究发现P2RY1与肿瘤的发生发展密切相关。位于细胞膜上的P2RY1受体在接受细胞外信号刺激后，激活下游相关信号通路，发挥相应生物学功能，继而对癌细胞的增殖、分化、凋亡等产生一系列影响。本研究目的旨在运用分子生物学方法对P2RY1在低分化胃腺癌细胞的发生发展过程中的作用与相关分子机制及其生物学功能的调控进行探索研究。 方法：首先，通过胃癌样本的甲基化芯片筛选出P2RY1基因，同时在样本中通过westen ...
华应刚
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Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Early detection of thermal runaway (TR) is essential for lithium‐ion battery (LIB) safety, as unchecked TR risks catastrophic failures in energy storage systems. Gas‐based sensing offers a faster and more direct approach by detecting decomposition products at the molecular level.
Tianshui Liang +9 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2010 目的研究非小细胞肺癌患者癌组织和血浆p16基因甲基化及其临床意义。方法选择120例非小细胞肺癌患者,用巢式甲基化特异性聚合酶链反应法检测其肺癌组织、癌旁正常组织和外周血血浆p16基因的甲基化,并对120例正常对照组血浆样品进行p16基因甲基化检测,各组检测结果进行比较。结果肺癌组织p16基因甲基化率44.2%,高于癌旁组织的11.7 ...
陈首慧 +8 more
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On the Damage Tolerance of Diffusion Bonded Titanium–Aluminum Phase Biomimetic Composites
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT The biomimetic design principles of natural structures involve the strategic integration of stiff and compliant phases to synergistically enhance strength and toughness. Its evolutionary refined natural armor, characterized by a specialized microarchitecture, enables superior damage tolerance.
Shuai Tong +10 more
wiley +1 more source
Influence of cage culture on methylmercury in water column of reservoir [PDF]
, 2012 To understand the influence of cage culture on the methylmercury production and distribution in water column of reservoir, water samples were collected from four cage culture sites in Wujiangdu Reservoir in September (warm season), 2010 and in March ...
Feng, Caiyan +3 more
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Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Developing efficient and sustainable energy conversion technologies is crucial for addressing the global energy and environmental challenges. As a promising clean energy conversion strategy, the electrocatalytic methanol oxidation coupled with cathodic hydrogen production provides a pivotal path to solve the above problems.
Tao Chen +4 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2009 目的研究人胃癌细胞系端粒酶逆转录酶基因（hTERT）启动子区域是否存在甲基化,甲基化程度是否与肿瘤的恶性程度相关。方法运用甲基化特异性PCR（MSP）方法,以人乳腺癌细胞、人胚肺成纤维细胞作为阳性及阴性对照,检测中、低分化的胃腺癌细胞系hTERT基因启动子区域甲基化情况。结果端粒酶阳性的胃癌细胞、人乳腺癌细胞均存在甲基化,而端粒酶阴性的人胚肺成纤维细胞不存在甲基化,不同分化程度胃癌细胞的hTERT启动子区CpG位点甲基化情况不同。结论hTERT基因启动子区域的甲基化,与细胞的分化程度相关 ...
王亚东 +3 more
doaj
Reprogramming of global histone methylation controls the differentiation of monocytes into macrophages [PDF]
, 2016 单核-巨噬细胞系统由一类具有吞噬功能的免疫细胞组成，包括单核细胞、巨噬细胞及树突状细胞，是机体免疫系统重要的组成之一。来源于造血干细胞的单核细胞在趋化因子激活下，分化为巨噬细胞和树突状细胞，参与机体防卫。目前有关单核-巨噬细胞分化的细胞学过程已基本阐释，然而分化进程中关键分子及其调控网络仍需要深入阐明。此外，单核细胞如果过度增生，会导致正常造血功能衰竭。白血病的发生也与单核-巨噬细胞系统的异常发展有关。因此，深入探索和阐明单核/巨噬细胞形成过程中关键转录因子及其调控网络 ...
王慧敏
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Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Deep eutectic solvents (DESs) have displayed a significant potential in green recycling of spent lithium‐ion batteries (LIBs) cathode materials. In this study, we proposed a computational screening strategy based on the binding energy and hydrogen bonding performance via density functional theory and molecular dynamic calculation, achieving a ...
Yang Chen +7 more
wiley +1 more source
Studies of Functions and Mechanisms of JMJD2D in the Development of Colorectal Cancer [PDF]
, 2015 结直肠癌（Colorectalcancer,CRC）是世界范围内的高发性恶性疾病，其发病率和死亡率呈逐年上升趋势，因而引起广大科研工作者对其发生发展的作用机制进行深入研究。文献报导称，在绝大多数结直肠癌的发生发展过程中都伴随着经典Wnt信号通路的异常激活。该通路激活后，其中最重要的效应分子之一β-Catenin入核与TCF/LEF家族成员结合，激活下游促癌基因转录表达，从而促进结直肠癌的发生发展。 组蛋白赖氨酸特异性去甲基化酶4D（Lysine-specificdemethylase4D,KDM4D ...
余力
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