感染性疾病具有较高的发病率及死亡率,因其临床表现及相关诊断标准缺乏特异性[1],使得该类疾病的早期识别及评估工作被延误。在此过程中,中性粒细胞过度激活,宿主对感染的免疫反应失调,进而导致严重的器官功能障碍——即脓毒症的发生[2]。脓毒症是机体严重感染的结果,是医院中常见的死亡原因,然而大约20%~30%的严重脓毒症患者在入院时没有表现出器官功能障碍等典型临床体征,相反,在入院后的24 h内,患者病情逐渐恶化为严重脓毒症[3-4],因此脓毒症早期的诊断及治疗显得尤为重要。
姜春如, 张春媚, 王帅, 赵忠岩
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