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二甲氨基偶氮苯(DAB)诱发大白鼠肝癌形成过程中葡萄糖:ATP-磷酸转移酶同工酶基因表达的改变 [PDF]

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 1986
原发性和移植性肿瘤都可能产生一些正常细胞所没有的蛋白质,这些蛋白质往往存在于同种组织的胚胎时期。例如甲胎蛋白(AFP)、癌胚抗原(CEA)和某些癌胚性同工酶。葡萄糖:ATP-磷酸转移酶同工酶是其中的一种。此酶在哺乳类动物肝脏中存在四型同工酶 ...
张勇
doaj   +2 more sources

鼻咽癌上皮性标志表达的异质性及其组型研究 [PDF]

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 1993
采用免疫组化方法,应用一组抗癌胚抗原(CEA)、上皮膜抗原(EMA)和不同分子量细胞角蛋白抗体,对123例不同组织学类型鼻咽癌上皮性标志的表达进行了研究。结果表明,鼻咽癌上皮性标志的表达既存在明显异质性,也存在一定规律性。鼻咽癌上皮性标志和细胞角蛋白的表达均可分别归纳为4种表达组型。这些表达组型与鼻咽癌组织学类型密切相关。一定的组织学类型总是显示一定相应的上皮性标志和细胞角蛋白的表达组型。在鼻咽癌的角化性鳞癌与腺癌、角化性鳞癌与非角化性癌、非角化性癌与鼻咽型未分化癌的鉴别中 ...
doaj   +2 more sources

手术前血清癌胚抗原与胃癌预后的关系 [PDF]

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 1988
癌胚抗原(CEA)测定作为消化道癌肿的一种诊断方法,由于其敏感性及特异性不强,其意义为大多数作者所否定,但在判断预后,估计手术后存活期和监视手术后癌肿复发等方面的作用,已经受到普遍的重视。有关手术前血清CEA水平与癌肿预后的关系,国外报道以大肠癌较多,胃癌较少。本文旨在探讨术前CAE测定与胃癌预后的关系。 材料和方法 一、病例资料 研究对象为1984年7月至1987年3月我院胃肠外科组收治的病理组织学为腺癌的胃癌96例,由于其他原因而手术前未测定血清CEA的病例未包括在内。96例中,男71例,女25例 ...
詹文华
doaj   +2 more sources

Pancreatic lymphoepithelial cyst: a case report [PDF]

open access: yes, 2023
Pancreatic lymphoepithelialcyst (PLEC) is a rare benign pancreatic cyst, which has been rarely reported in clinical practice. The incidence of PLEC is low and specific imaging and clinical manifestations are lacking.
Guan Wenting, Liang Jian, Zhou Yu
core   +1 more source

Test and Significance of CEA, NSE, CA125, CYFRA21-1 in Lung Cancer [PDF]

open access: yes, 2017
目的 探讨CEA、NSE、CA125、CYFRA21-1在肺癌中的检测及意义.方法 回顾性分析2015年10月—2016年12月医院收治的肺部疾病患者166例,其中89例肺癌患者设为肺癌组,其余77例肺部良性病变患者设为肺部良性病变组.另选择35名健康志愿者作为健康对照组,电化学发光法检测3组血清中CEA、NSE、CA125、CYFRA21-1含量,分析单项及联合检测对肺癌的诊断价值.结果 肺癌组患者血清CEA、NSE、CA125、CYFRA21-1分别为(4.32±0.83)ng/mL、(11.54 ...
何佳瑜, 何正, 罗世翊, 魏玲
core   +1 more source

Dual Checkpoint Inhibition with Ipilimumab plus Nivolumab After Progression on Sequential PD‐1/PDL‐1 Inhibitors Pembrolizumab and Atezolizumab in a Patient with Lynch Syndrome, Metastatic Colon, and Localized Urothelial Cancer

open access: yesThe Oncologist, Volume 24, Issue 11, Page 1416-1419, November 2019., 2019
Abstract Immune checkpoint blockade (ICB) is an approved therapy for advanced metastatic mismatch repair (MMR)‐deficient cancer regardless of tissue of origin. Although therapy is effective initially, recurrence rates are significant, and long‐term outcomes remain poor for most patients.
Arthur Winer   +7 more
wiley   +1 more source

Expression of plasma methylated Septin9 gene and its clinical significance in patients with gastric cancer [PDF]

open access: yes, 2023
Background and purpose: Gastric cancer is one of the most common malignant tumors in our country. The diagnosis and treatment process of gastric cancer lacks of sensitive and specific biomarker.
CHEN Xinning, JIANG Huiqin, YANG Yihui, YU Qian, ZHANG Chunyan, WANG Beili, PAN Baishen, GUO Wei
core   +1 more source

Analysis of efficacy of hepatectomy and prognostic risk factors in patients with gastric cancer with synchronous liver metastasis [PDF]

open access: yes, 2023
Background and purpose: Whether patients with gastric cancer with synchronous liver metastases (GCLM) receive hepatectomy remains controversial. In this study, we analyzed the clinicopathological characteristics and treatment modalities of patients with ...
ZOU Ting, LIU Xiaowen
core   +1 more source

食管癌患者手术前后四种血清肿瘤标志物水平变化的临床意义

open access: yesZhongguo shiyan zhenduanxue, 2020
食管癌为常见的恶性肿瘤之一,临床早期不易被发现,具有较高的发病率和死亡率。研究表明当人体消化系统出现病变时,机体内相关血清指标会随之而改变[1-3]。本文通过监测食管癌患者手术前后血清中鳞状细胞癌抗原(SCC)、癌胚抗原(CEA)、糖类抗原199(CA199)、细胞角蛋白19片段(CYFRA21-1)四种肿瘤标志物水平的变化,探讨以上肿瘤标志物对食管癌诊断以及预后判断的评估价值。
李春霖   +9 more
doaj  

Potential Diagnosis and Prognosis Value of Plasma MicroRNA-19a in Esophageal Cancer [PDF]

open access: yes, 2015
背景:食管癌是发生于食管上皮组织的恶性肿瘤,具有高死亡率、高复发率和高转移率的特点。然而目前针对食管癌敏感的肿瘤标志物不多,且诊断效率较低,远远不能满足临床需求。MicroRNA是一类非编码RNA,可以稳定存在于人体血浆中并且易于检测。据报道,microRNA在诸多疾病状态下会出现表达异常,如食管癌、结直肠癌、肝癌等,这一发现极大地增加了血浆microRNA作为食管癌标志物的可能。在前期实验中,我们观察到microRNA-19a(miR-19a)在食管癌血浆标本中高表达,本文将重点探讨miR ...
白永颖
core  

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