Results 21 to 30 of about 24,587 (167)
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Articular cartilage regeneration remains a significant challenge because of its limited intrinsic healing capacity and the inadequacy of conventional treatments for restoring structural and functional integrity. In this study, a novel injectable composite hydrogel scaffold was designed to mimic the extracellular matrix (ECM) of native ...
Zhong‐Lian Wu +13 more
wiley +1 more source
Integrative Conservation, Volume 4, Issue 4, Page 652-664, December 2025.We profiled nutritional and physiological markers in captive sifakas, endangered primates from Madagascar, managed in expansive, non‐native forest enclosures. Variation in many markers reflects freely foraged diets and the energy required to maintain homeostasis under more naturalistic conditions.
Lydia K. Greene +5 more
wiley +1 more source
The Genome of Phoebe zhennan (Lauraceae) and Comparative Genomics of Phoebe 楠木(樟科)基因组与楠属植物比较基因组学研究
Integrative Conservation, Volume 4, Issue 4, Page 584-599, December 2025.Phoebe zhennan is a Chinese endemic and valuable timber species of Phoebe (Lauraceae). We present a chromosome‐level genome assembly of P. zhennan. Our research provides novel insights into the genome evolution of Phoebe, including whole‐genome duplication, phylogenetic relationships of magnoliids, and key MYB regulatory genes involved in lignin ...
Mao Yameng +3 more
wiley +1 more source
The effects of ubiquitination inhibitors Thalidomide and PYR-41 on cross-presentation of dendritic cells [PDF]
, 2016 树突状细胞(Dendriticcells，DCs)是机体最为重要的抗原提呈细胞(Antigenpresentingcell，APC)。DCs对抗原的交叉提呈是指外源性抗原被DCs摄取和加工后，与MHCI类分子结合形成CD8+特异性抗原肽-MHCI类分子复合物的过程，可使T细胞分化为CD8+特异性细胞毒T细胞(CytotoxicTlymphocyte，CTL)。甘露糖受体(Mannosereceptor，MR)是DCs表面重要的的模式识别受体(Patternrecognitionreceptor，PRR)，
游翔
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Functional Ecology, Volume 39, Issue 12, Page 3487-3503, December 2025.Read the free Plain Language Summary for this article on the Journal blog. Abstract Many broad‐scale studies along spatial and habitat gradients show that organisms' traits can strongly influence community assembly by facilitating dispersal and environmental filtering.
Mark K. L. Wong +6 more
wiley +1 more source
Calcitriol inhibits advanced glycation end product (AGE)-elicited mesangial cell damage by sequestrated RAGE-NF-κB Signaling [PDF]
, 2015 维生素D是通过与骨，甲状旁腺，肾脏和胃肠道的相互作用调节钙稳态，已经被用来作为糖尿病肾病（DKD）的常规用药。几个临床试验表明，维生素D在糖尿病肾病的治疗中，存在着减少蛋白尿和减缓肾损伤的抗炎作用，但其作用机制尚不清楚。而晚期糖化终产物（AGEs）在血浆和肾的积累，在糖尿病肾病中，是大家公认的促炎症分子。为了探索这种抗炎作用，我们设计实验。 研究目的：探寻骨化三醇减少AGEs引起的人肾系膜细胞炎症反应的机制，具体是探寻骨化三醇对AGEs引起的人系膜细胞表达白细胞介素-6（IL-6）和单核细胞趋化因子 ...
刘波
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Veterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis +9 more
wiley +1 more source
Study on establishing an approach for rapid screening RXRα ligands from medicinal herbs [PDF]
, 2016 维甲酸X受体α（RXRα）是研究抗癌药物的重要靶点之一，其配体Targretin已由FDA批准用于治疗皮肤癌，目前已知的天然RXRα小分子配体非常有限，因此建立一种新的活性筛选模型从中药及天然产物中快速发现以RXRα为活性靶点的新型小分子配体具有重要意义。 前期研究发现黄牛木属植物中的氧杂蒽酮类化合物能够抑制RXRα的转录活化功能，其中，CF-31能够直接与RXRα通过疏水性相互作用的方式结合，因此，本研究以黄牛木属植物黄牛木和红芽木为拟建立活性筛选体系的候选药材，对其60%乙醇水提取物经大孔树脂90 ...
陈虹
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External validation of QUiPP App in three independent European cohorts of symptomatic women
Ultrasound in Obstetrics &Gynecology, Volume 66, Issue 2, Page 163-174, August 2025.ABSTRACT Objective To validate externally the QUantitative Innovation in Predicting Preterm birth (QUiPP) App v.2 for the prediction of spontaneous preterm birth (sPTB) in symptomatic women attending tertiary care in Europe. Methods The QUiPP App v.2 was validated in three independent datasets: a prospective European multicenter cohort across five ...
A. M. Fischer +8 more
wiley +1 more source
Experimental study on effect of bone marrow mesenchymal stem cells on the function of severe fatty liver graft [PDF]
, 2015 第一章：大鼠骨髓间充质干细胞的分离、培养与鉴定 目的体外培养活性好、纯度高的骨髓间充质干细胞 方法采用密度梯度离心法分离培养骨髓间充质干细胞，采用流式细胞仪鉴定其表面抗原的表达情况，用成软骨试剂、成脂试剂诱导BMSCs分化成软骨细胞、脂肪细胞。 结果获得细胞具有明显的贴壁性，其细胞表面高表达CD44、CD90、CD29抗原分子，低表达CD45、CD34、CD11b抗原分子。成软骨诱导分化3周，BMSCs即可分化成软骨细胞，成脂诱导分化2周，即可分化成脂肪细胞。 结论密度梯度离心法可以获得活性好、纯度高 ...
范洪凯
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