Results 21 to 30 of about 43,834 (216)
Roles of TIF1β in Leukemic Stem Cell Through SETDB1‐Dependent and Independent Mechanisms
Cancer Science, EarlyView.In leukemic stem cell, BCR::ABL cooperates with TIF1β to open chromatin at oncogenes and close chromatin at differentiation regulators, driving leukemic reprogramming. In TIF1β‐deficient stem cell, the loss of TIF1β inverts this balance, showing closed chromatin at oncogenes and open chromatin at differentiation regulators.
Mariko Morii, Sho Kubota, Goro Sashida
wiley +1 more source
Veterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis +9 more
wiley +1 more source
Dermoscopic evaluation of normal canine skin with a handheld dermoscope
Veterinary Dermatology, Volume 36, Issue 5, Page 593-601, October 2025.Background – Dermoscopy is a noninvasive diagnostic tool that provides a magnified view of skin structures. While dermoscopy is described for certain canine dermatological diseases, large‐scale studies evaluating normal skin are lacking. Hypothesis/Objective – This study aimed to correlate dermoscopic findings with histopathological results in healthy ...
Rachael Loek +4 more
wiley +1 more source
亚洲临床医学杂志, 2019 感染是白血病病人骨髓移植死亡的最主要原因之一，手术之后感染不仅会造成患者经济负担的加大，还会给患者带来生命危险，增加患者的痛苦。本文主要针对白血病病人骨髓移植之后的相关感染因素进行探究，提出了具体的护理对策和护理措施，希望能够加强白血病病人骨髓移植后的感染预防效果，提高护理工作的安全性。
玲 黄, 苒 罗
semanticscholar +1 more source
Cancer Medicine, Volume 14, Issue 15, August 2025.ABSTRACT Background While tyrosine kinase inhibitor (TKI) discontinuation is an established therapeutic goal, up to 60% of patients relapse after the first attempt. The feasibility of a second or third attempt at TKI discontinuation remains uncertain.
Hiroshi Ureshino +6 more
wiley +1 more source
Ultrasound in Obstetrics &Gynecology, Volume 66, Issue 2, Page 200-209, August 2025.Abstract Objectives Neonates with critical congenital heart disease (CCHD) are at risk for adverse early brain development and long‐term neurodevelopmental sequelae. Insulin‐like growth factor‐1 (IGF‐1) and insulin‐like growth factor binding protein‐3 (IGFBP‐3) are essential contributors to brain growth and maturation.
M. Nijman +33 more
wiley +1 more source
Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 4, Page 447-455, April 2025.ABSTRACT Objective A soluble fms‐like tyrosine kinase‐1 (sFlt‐1)‐to‐placental growth factor (PlGF) ratio cut‐off of 38 is currently considered optimal for ruling out pre‐eclampsia (PE); however, implementation of this ratio in clinical practice is limited.
M. N. Nan +15 more
wiley +1 more source
伴有髓系抗原标记的儿童急性B淋巴细胞白血病患者血液形态学、流式免疫表型特点研究
Zhongguo shiyan zhenduanxue, 2021 急性B淋巴细胞白血病是临床上高发的儿童恶性肿瘤疾病,一般占儿童恶性肿瘤疾病发病率的20%以上,发病率近年来呈逐年增加的趋势[1-2]。急性B淋巴细胞白血病是急性白血病最常见的类型,但是由于该疾病涉及数十种特异染色体异位形成一种融合基因,而多种融合基因也导致了急性B淋巴细胞白血病发病机制的复杂性,从而给临床医师治疗形成了巨大的困难[3-4]。本次研究分析伴有髓系抗原标记的儿童急性B淋巴细胞白血病患者血液形态学、流式免疫表型特点,为临床医师治疗急性B淋巴细胞白血病患儿提供理论依据,现报道如下。
焦聿墨, 马林通, 王鼎, 赵鹏
doaj
テンシャ インシ Hes1 ニヨル キュウセイ コツズイセイ ハッケツビョウ ノ ハッショウ ヨクセイ ゲンショウ ノ ハッケン ト ソノ ブンシ キコウ ノ カイセキ [PDF]
, 2012 筑波大学博士 (医学) 学位論文・平成24年3月23日授与 ...
加藤 貴康
core +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2002 【目的】探讨细胞间黏附分子-1(CD54)在恶性血液病的表达。【方法】用免疫荧光方法检测19 例急性髓系白血 病, 34 例急性淋巴细胞白血病, 10 例慢性粒细胞白血病, 15 例多发性骨髓瘤, 21 例非霍奇金淋巴瘤和16 例正常人骨髓单个核 细胞表达CD54 。【结果】①除多发性骨髓瘤、慢性粒细胞性白血病外, 急性髓性白血病细胞、非霍奇金淋巴瘤、急性淋巴细胞 白血病患者骨髓单个核细胞表面CD54表达低于正常人。②CD54在急性早幼粒细胞白血病(M3)表达高于在其它类型急性髓 ...
童秀珍 +5 more
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