淀粉样前体蛋白胞内结构域对阿尔茨海默病模型小鼠神经发生和学习记忆的影响
Zhongshan Daxue xuebao. Yixue kexue ban目的探讨淀粉样前体蛋白胞内结构域（AICD）对阿尔茨海默病（AD）模型动物神经发生、学习记忆的影响。方法本研究使用免疫荧光染色检测AICD转基因小鼠来源的体外培养的神经前体细胞（NPCs）、胚胎大脑皮质、成年海马齿状回（DG）中增殖和分化的细胞数目；水迷宫实验检测老年AICD转基因小鼠对学习记忆能力影响；生物信息学预测和分析潜在的分子机制。结果免疫荧光染色结果显示AICD转基因模型体外NPCs、胚胎皮质、海马DG区域的神经干细胞和神经元数量减少（P < 0.05 ...
蒋梅 +4 more
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[Sulforaphane reduces reactive astrocyte-mediated neuron apoptosis <i>in vitro</i> by inhibiting the MAPK/NF-κB signaling pathway in Aβ42 oligomer-activated astrocytes]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoZhang S +5 more
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[Kahweol improves motor function of mice with spinal cord injury by inhibiting microglial activation <i>via</i> regulating the IκBα/NF-κB pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoXia J +6 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 1994 用免疫组织化学ＡＢＣ方法，研究Ｐ物质（ＳＰ）样免疫反应性神经元在蟾蜍视网膜的定位与分布。结果表明：在５８０个免疫反应阳性细胞中。４３％为Ⅰ型无长突细胞，４１％为Ⅱ型无长突细胞，１６％的细胞体位于节细胞层，暂定为移位无长突细胞。ＳＰ样免疫反应突起分布于内网层的第１、３、５亚层，以第３亚层最丛密，形成一致密的网层，第５亚层次之，第１亚层最稀少，不形成连续的网层。在视网膜平铺片上，ＳＰ样免疫反应细胞体均匀分布于视网膜中央区和周围区，其密度为５３６±１０７个／ｍｍ２（平均数±标准差 ...
doaj
[Temporal changes of chronic postsurgical pain in mice: the regulatory role of CX3CL1 in the dorsal root ganglion]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoZhao B +8 more
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[Role and Mechanism of High Mobility Group Box 1 in Mediating Depression-Like Behaviors in Mice via Regulation of the 5-Hydroxytryptamine Receptor 7 Signaling Pathway]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanDU O, Duan S, Tang L, DU J.
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Zhongshan Daxue xuebao. Yixue kexue ban, 1989 用卵白素生物素过氧化物酶复合物(ABC)法研究大鼠脑中催产素(OT)和加压素(VP)免疫反应性物质的分布。阳性细胞主要局限于下丘脑,而阳性纤维则广泛分布于下丘脑和脑干等部位。OT和VP的分布情况有差别。在视上核和室旁核大细胞后部,VP阳性大细胞明显比OT大细胞密集;同样,在向正中隆起方向行走的阳性纤维束中,VP纤维也占大多数。而在室旁核尾部的小细胞内侧部,中小型OT阳性细胞比VP细胞密集;并且,在脑干的孤束核、三叉神经脊束核、迷走背核、疑核、臂旁核和蓝斑核中,OT阳性纤维也占主要地位。 实验结果提示 ...
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[Electroacupuncture improves post-traumatic stress disorder in rats by alleviating hippocampal mitochondrial injury <i>via</i> regulating Bcl-2/Bax/caspase-3 signaling]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoMa D, Cheng J, Zhang H, Liu G, Song K.
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[Correlation of Serum Neuron-Specific Enolase, Angiopoietin-1, and Angiopoietin-Like Protein-3 With Disease Severity and Their Prognostic Value in Patients With Cerebral Infarction]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanLiu J, Gao H, Liu Y.
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