Zhongshan Daxue xuebao. Yixue kexue ban, 1980 萘普生(Naproxen)是芳基乙酸类消炎镇痛药。Harrison等曾指出它具有抗炎作用,Roszkowski在动物实验中证明萘普生具有高效的消炎止痛退热作用。Dorfman在该药国际专题讨论会上作了该药动物实验的综述。在临床试用结果亦证明该药对类风湿关节炎、骨关节炎和非关节性风湿病、痛风和一些疼痛具有良好的作用。由于该药疗效好,副作用小,英国已收载于1978年药典。国内广州第八制药厂已合成成功试产。本文主要是就该厂提供的萘普生[d-2-(6’-甲氧基-2’-萘基)丙酸)进行镇痛、消炎、退热等药理研究。
赵香兰
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Clinical research on progress of antinuclear antibody in rheumatoid arthritis [PDF]
, 2023 Rheumatoid arthritis (RA) is a common chronic, systemic autoimmune disease characterized by erosive arthritis, with a global prevalence of 0.25% to 1.00%, which may ultimately lead to joint deformity and loss of function.
LI Yuan, ZHANG Le, YIN Hanlin, ZHENG Bing, LÜ Liangjing
core +1 more source
Efficacy of Two Drug Regimens in the Treatment of Severe Disease Activity Rheumatoid Arthritis [PDF]
, 2017 目的 对重度疾病活动度类风湿关节炎患者用两种药物治疗方案的治疗效果进行探讨分析。方法 随机抽取本院2015年6月—2016年6月收治的40例重度疾病活动度类风湿关节炎的患者作为研究对象,并将其分为对照组和实验组各20例,对照组采用来氟米特联合甲氨蝶呤进行治疗,实验组在此基础上加入沙利度胺进行治疗,对两组的治疗效果进行对比分析。结果 实验组的治疗效果优于对照组的治疗效果,关节肿胀等不良反应均得到了有效的改善,差异具有统计学意义（P〈0.05）。结论 三种药物联合的治疗效果优于两种药物联合的治疗效果 ...
陈煜
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, 2019 类风湿关节炎（Rheumatoid arthritis,RA）是以侵蚀性、对称性多关节炎为主要表现的慢性、全身性自身免疫性疾病, 最终发展为关节畸形和功能丧失, 并损害心、肺、肾、神经等器官[1]。我国RA的发病率为0.32%～0.36%。该病具有病程长、复发率高、致残率高等特点,在临床上又被称为\"不死癌症\"[2],严重危害患者健康。该病治疗的目的是缓解疼痛,提高关节活动度,阻止残疾的发生。康复功能锻炼是降低国家自然科学基金资助项目(编号 ...
刘丽静 +6 more
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Research Progress on the Synthesis and Bioactivities of Indole-3-glyoxylamide Derivatives [PDF]
, 2017 综述了吲哚-3-乙醛酰胺类化合物(ID)的合成及生物活性的研究进展。ID具有抗肿瘤、抗病毒、抗菌、抗炎、腺苷受体功能调节、缓解疼痛和抗类风湿关节; 炎等多种生物活性,在药物化学领域有广泛应用。ID的合成方法主要为:吲哚母核与乙酰氯在乙醚(或THF)中于室温反应1; h制得含草酰氯结构的中间体;中间体与取代胺基化合物和二异丙基胺乙基胺反应合成ID。并对ID未来的应用作了简要展望。The synthesis and bioactivities of indole-3-glyoxylamide ...
方美娟, 王飞, 胡鸿雨, 赵胜贤
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Suggestions for Chinese Dietary Lipids Reference Intakes in the New Period [PDF]
, 2022 With the rapid development of economy and society, the dietary pattern of Chinese residents has undergone obvious transition. The recommendation of dietary lipids intake has a significant influence on the improvement of dietary pattern and on the ...
JIA Shan-shan, PANG Shao-jie, ZHANG Jian
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Lenalidomideas a Second-line Therapy Achieves Long-term Remission in Elderly Patients with Relapsed/Refractory Multicentric Castleman's Disease：a Report of Two Cases and Literature Review [PDF]
, 2022 No standard therapy is recommended for elderly multicentric Castleman's disease (MCD) patients who failed to the first-line treatment or relapsed. Lenalidomide has been reported to be effective for relapsed/refractory MCD in foreign countries, but ...
TANG Yangming, SHI Renzhou, LAN Mei, LI Xuejun, WEN Zonghua, LU Xiaochen
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Trial of Chloroquines in the Treatment of COVID-19 and Its Research Progress in Forensic Toxicology [PDF]
, 2020 Chloroquines are the long-established prescription drug, which are often used clinically to treat malaria and connective tissue diseases. Since December 2019, corona virus disease 2019 （COVID-19） outbreaks caused by 2019 novel coronavirus （2019-nCoV） has
DUAN Yi-jie*, LIU Qian*, ZHAO Shu-quan, et al.
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TIPE2 promote synovial fibroblasts cell apoptosis of adjuvant arthritis rats by up-regulating caspase while down-regulating NF-κB [PDF]
, 2015 目的：TIPE2能够抑制炎症以及肿瘤的发生发展，并且TIPE2过表达能够促进细胞的凋亡。类风湿关节炎是一种免疫多态性慢性疾病，我们应用类风湿关节炎模型大鼠佐剂型关节炎滑膜成纤维样细胞(fibroblast-likesynoviocytesofratadjuvantarthritis，AA-FLS)，通过体外实验分析TIPE2对死亡受体5诱导细胞凋亡的作用探讨TIPE2对佐剂型关节炎发病的影响。 方法：通过RT-PCR、荧光实时定量PCR和Western ...
石春燕
core
The role of histone acetylation in Rheumatoid arthritis peripheral blood mononuclear cells [PDF]
, 2016 研究背景类风湿关节炎（rheumatoidarthritis，RA）是一种常见的全身性自身免疫疾病，以慢性、进行性、侵袭性关节炎为主要临床表现。该病发病机制尚不明确，研究其发病机制对临床指导治疗具有极其深远的意义。组蛋白乙酰化在RA的发病机制中具有重要作用。组蛋白乙酰化是一种可逆的动态过程，主要由组蛋白乙酰转移酶(histoneacetylase，HATs)和组蛋白去乙酰化酶(histonedeacetylases，HDACs）协调修饰。既往研究中，Huber，L.C.等人的研究显示 ...
宋丽娜
core