Results 51 to 60 of about 144,107 (264)

Aldose reductase regulates miR-200a/miR-141 to impact TGFβ signaling and renal fibrogenesis [PDF]

open access: yes, 2012
醛糖还原酶(aldosereductase,AR)是多元醇糖代谢支路的限速酶。已有很多研究证实AR在糖尿病并发症如糖尿病神经病、糖尿病视网膜病中起到重要的作用。我们前期的工作表明,AR的遗传缺失抑制了高糖引起的PKC/TGFβ的激活,进而显著减缓了C57BL/6小鼠糖尿病肾病的进程(Liuetal.,Diabetologia,2011)。然而,AR是如何调控TGFβ和肾细胞纤维化却不清楚。本研究因而在肾细胞和组织中探讨了AR对miR-200a/miR-141等表达的影响,以及miR-200a/miR ...
张晔
core  

Risk factors for chronic kidney disease progression over 20 years for primary prevention in Japanese individuals at a preventive medicine research center: Focus on the influence of plasma glucose levels

open access: yesJournal of Diabetes Investigation, Volume 15, Issue 10, Page 1434-1443, October 2024.
For early intervention against a reduction in the estimated glomerular filtration rate, detecting mild increases in fasting plasma glucose ≥105 mg/dL in patients with chronic kidney disease with or without diabetes is useful. We would like to propose that a fasting plasma glucose level ≥105 mg/dL is an independent risk factor for the progression of ...
Kento Minami   +13 more
wiley   +1 more source

2型糖尿病视网膜病变与下肢血管病变的关系

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2017
【目的】探讨2型糖尿病患者糖尿病视网膜病变与下肢血管病变是否存在共同的危险因素及预测关系。【方法】 对99例糖尿病下肢血管病变的患者行双侧胫前动脉、胫后动脉、足背动脉共6条血管的超声检查,每条血管根据狭窄程度 评分,狭窄程度在30% ~ 49%评0分,50% ~ 99%评1分,管腔闭塞者(即狭窄100%)评2分,各段血管评分相加为总得分;0- 2分为1级,3 ~ 4分为2级,5 ~ 12分为3级。同时对这些患者行眼底检查,判断视网膜病变情况。分析2型糖尿病视网膜病 变与下肢血管病变的关系。【结果】
张丹乔   +3 more
doaj  

糖尿病における口腔粘膜の創傷治癒遅延のメカニズムについて [PDF]

open access: yes, 2010
糖尿病患者における口腔粘膜の創傷治癒が遅延するメカニズムについて、口腔粘膜の創傷治癒とそれに影響を及ぼす因子、糖尿病での血流・血管新生、免疫能の変化、糖尿病での唾液量と成分の変化、糖尿病での成長因子の変化、糖尿病患者の心理的ストレスに分けて考察した。創傷治癒遅延には様々な現象が関わると考えられ ...
古市 保志   +5 more
core   +1 more source

多样性护理对糖尿病合并冠心病患者的干预疗效观察

open access: yes亚洲临床医学杂志, 2020
目的: 探究糖尿病合并冠心病患者临床护理中应用多样性护理的疗效。 方法: 将 2017 年 10 月 -2018 年 10 月,就诊我院符合糖尿病合并冠心病的诊断标准的患者 76 例,以随机数字表法分组为常规组(常规护理)、研究组(多样化护理干预),各纳入 38 例,对比血糖控制水平、生活质量、护理满意度。 结果: 干预后研究组血糖下降程度比常规组更显著 ...
晶 曲, 洪英 马, 璐璐 白
semanticscholar   +1 more source

Maternal prepregnancy weight as an independent risk factor for congenital heart defect: systematic review and meta‐analysis stratified by subtype and severity of defect

open access: yesUltrasound in Obstetrics &Gynecology, Volume 64, Issue 3, Page 294-307, September 2024.
ABSTRACT Objective To assess the association between increased maternal prepregnancy body mass index (BMI) and the risk of congenital heart defect (CHD) in offspring. Methods This systematic review and meta‐analysis searched PubMed/MEDLINE, Web of Science and Scopus from inception to 20 April 2023.
N. Salmeri   +5 more
wiley   +1 more source

谷氨酸脱羧酶抗体对 1 型糖尿病的诊断意义

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 1998
目的: 探讨谷氨酸脱羧酶(GAD)抗体与 1 型糖尿病患者发病年龄、病程及临床特征等的关系。方法: 用放射免 疫沉淀法测定 92 例 1 型糖尿病和 53 例 2 型糖尿病患者血中 GAD 抗体。结果: 1 型糖尿病组总的 GAD 抗体阳性率为 39. 1%, 其中儿童 1 型糖尿病组、成人 1 型糖尿病组和成人晚发 1 型糖尿病组的阳性率分别为 46. 7%、36. 8%和 40. 0%,组间 无差异; 而病程≤1 a 的阳性率 58. 8%,明显高于病程>1 a 组的 27.
修玲玲 余斌杰 胡少眉 许善真 程 桦 曾龙驿
doaj  

High risk factors of diabetic foot and related nursing interventions (糖尿病足的高危因素分析及护理干预现状)

open access: yes中西医结合护理, 2022
The diabetic foot is one of the severe complications in diabetic patients. It's also a major cause of disability and death. This paper summarized and outlined the risk factors, prevention points and nursing interventions for diabetic foot by literature ...
JI Congying (季聪颖)
doaj   +1 more source

肾脏-胰岛联合移植研究进展 [PDF]

open access: yes, 2018
糖尿病肾病是糖尿病最严重的并发症,可通过间质及肾小管纤维化等机制导致肾脏功能衰竭,最终进展为终末期肾脏病(end stage renal disease,ESRD)[1-2]。既往认为,糖尿病肾病及其他慢性肾病患者更容易死于心血管疾病而不是ESRD,但是据一份2型糖尿病(type 2 diabetes mellitus,T2DM)随访统计 ...
夏俊杰   +3 more
core  

An exploratory study of factors in disordered eating behavior in diabetes self‐management in Japan

open access: yesJournal of Diabetes Investigation, Volume 15, Issue 7, Page 874-881, July 2024.
Negative mood especially anger and hostility is an important factor in appetite control and increased cortisol secretion, and can be an impediment to successful dietary self‐management in patients with type 2 diabetes. ABSTRACT Aims/Introduction Diet directly affects glucose metabolism, and eating behavior is influenced by various daily life stressors.
Sachiko Tsukamoto‐Kawashima   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy